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C Schaller

Publications and source records attributed to C Schaller.

At least 37 records · Page 2Linked to original sources
PubMed2001

[Microcirculatory changes in the development of the cerebrovascular adaptation].

Recently, long-term cerebrovascular adaptations after unilateral carotid ligation that increase the tolerance of the brain to subsequent episode of ischemia was reported(J Cereb Blood Flow Metab, 1998). However, the pathophysiological mechanisms underlying the phenomenon was unknown. We examined regional cerebral blood flow(rCBF) before, during and after subsequent ischemia in the development of the adaptation. Male Wistar rats(n = 18) were used. Unilateral(right) carotid artery ligation was performed 3 hours(group A: n = 8), 3 days(group B: n = 10) before forebrain ischemia. With bilateral carotid arteries occlusion, mean arterial blood pressure(MABP) was reduced by hypobaric hypotension down to 50 mmHg and maintained constant for 30 min. After hypotension, the experiment continued for 90 min. Local CBF were registered at 25(5 x 5) identical locations by laser Doppler scanning in the cortex during the experiment in bilateral hemispheres(at control phase, after the left carotid artery ligation, during ischemia and after hypotension). The physiological variable such as blood pressure and gas analysis were within normal range in all groups. There were no differences of rCBF between the right and left hemispheres in group A during the experiment. In group A, rCBF of both hemispheres significantly decreased after the ligation of the left carotid artery, during the induced ischemia (P < 0.05), and recovered to the value of before ischemia. Whereas, in group B rCBF of the left side(non-occluded side) decreased after the ligation of the left carotid artery, during the induced ischemia(P < 0.05), and recovered to the value of before ischemia, but rCBF of the right side(occluded side) decreased only during the induced ischemia(P < 0.05) and rCBF of the right side was significantly higher than the left brain after ligation of the carotid artery, during ischemia and after hypotension(P < 0.05). On the basis of these data, we concluded that cerebrovascular adaptations can be acquired by 3 days after unilateral carotid artery occlusion and the tolerance phenomenon is certainly attributed to microcirculatory improvement.

Animals↗
PubMed2000

Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy.

OBJECTIVE: To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm. METHODS: The authors performed a retrospective evaluation of patient data obtained during presurgical evaluation, with additional CSF analyses, serum analyses, and histopathologic investigations. RESULTS: The patients shared the following clinical features: onset of the disease in young adulthood with subacute onset or exacerbation of frequent intractable temporal lobe seizures, verbal and visual memory deficits, and affective abnormalities. MRI showed variably extended areas of increased T2 signal in limbic structures and adjacent areas. In the histopathologic investigation, chronic inflammation was observed without evidence of a viral origin. There was no evidence of an underlying malignancy. CONCLUSIONS: Nonparaneoplastic limbic encephalitis should be included in the differential diagnosis of adult patients with temporal lobe epilepsy.

Adult↗
PubMed2000

Is there a benefit of preoperative meningioma embolization?

OBJECTIVE: To evaluate the effect of preoperative embolization of meningiomas on surgery and outcomes. METHODS: In a prospective study, 60 consecutive patients with intracranial meningiomas who were treated in two neurosurgical centers were included. In Center A, embolization was performed for none of the patients (n = 30). In Center B, 30 consecutive patients with embolized meningiomas were treated. Preoperatively, tumor size and location, neurological status, and Barthel scale score were recorded. In Center B, the extent of tumor devascularization was evaluated using angiography and postembolization magnetic resonance imaging. Intraoperatively, blood loss, the numbers of blood units transfused, and the observations of the neurosurgeon concerning hemostasis, tumor consistency, and intratumoral necrosis were recorded. Postoperatively, the neurological status and duration of hospitalization were recorded. Six months after surgery, the outcomes were assessed using the Barthel scale and neurological examinations. RESULTS: The mean tumor sizes were 22.9 cc in Center A and 29.6 cc in Center B (P > 0.1). The mean blood losses did not differ significantly (646 ml in Center A versus 636 ml in Center B; P > 0.5). However, for a subgroup of patients with subtotal devascularization (>90% of the tumor) on postembolization magnetic resonance imaging scans in Center B, blood loss was less, compared with the entire group in Center A (P < 0.05). The observations of the neurosurgeon regarding hemostasis, tumor consistency, and intratumoral necrosis did not differ significantly. There were no surgery-related deaths in either center. The rates of surgical morbidity, with permanent neurological worsening, were 20% (n = 6) in Center A and 16% (n = 5) in Center B. There was one permanent neurological deficit (3%) caused by embolization. CONCLUSION: In this preliminary study, only complete embolization had an effect on blood loss. The value of preoperative embolization for all meningiomas must be reconsidered, especially in view of the high costs and risks of embolization.

Adult↗
PubMed1999

Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development.

Recently, sortilin a non G-protein-coupled receptor has been identified as the 100-kDa neurotensin receptor. In this paper we describe the expression of its gene during mouse embryonal development. We show that the nervous system is the main location of sortilin gene expression and that with ongoing development the forebrain exhibits the highest accumulation of transcripts.

Adaptor Proteins, Vesicular Transport↗
PubMed1999

Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative.

(-)-(3aS,5S,6S.6aR)-3a,5,6,6a-Tetrahydro-5,6-isopropylide nedioxyfuro [2,3-d]isoxazole-3-methanol ((-)-5) has been tested toward 25 glycohydrolases and found to inhibit beta-galactosidase from Aspergillus niger (Ki = 18 microM) and that from Aspergillus orizae (Ki = 72 microM). Hydrolysis of the acetonide or exchange of CH2OH group for a CHO, CH2OMe or a CH2OMOM group suppresses the inhibitory activity.

Aspergillus↗
PubMed1999

Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment.

Primary central nervous system lymphomas (PCNSLs) have recently received considerable clinical attention due to their increasing incidence. To clarify the histogenetic origin of these intriguing neoplasms, PCNSLs from 10 HIV-negative patients were analyzed for immunoglobulin (Ig) gene rearrangements. All tumors exhibited clonal IgH gene rearrangements. Of the 10 cases, 5 used the V4-34 gene segment, and all of these lymphomas shared an amino acid exchange from glycine to aspartate due to a mutation in the first codon of the complementarity-determining region 1. No preferential usage of D(H), J(H), V(kappa), J(kappa), V(lambda), or J(lambda) gene segments was observed. All potentially functional rearrangements exhibited somatic mutations. The pattern of somatic mutations indicated selection of the tumor cells (or their precursors) for expression of a functional antibody. Mean mutation frequencies of 13. 2% and 8.3% were detected for the heavy and light chains, respectively, thereby exceeding other lymphoma entities. Cloning experiments of three tumors showed ongoing mutation in at least one case. These data suggest that PCNSLs are derived from highly mutated germinal-center B cells. The frequent usage of the V4-34 gene and the presence of a shared replacement mutation may indicate that the tumor precursors recognized a shared (super) antigen.

B-Lymphocytes↗
PubMed1999

Percutaneous ventriculostomy--evolution of a device.

The technique applied for external ventriculostomy should allow simple, fast, stable and clean performance of this procedure. The stepwise development of a metallic ventriculostomy kit should help overcome shortcomings of traditional methods of external ventriculostomy such as catheter obstruction and propensity for infection. A rigid ventriculostomy set for precoronary puncture was developed, consisting of a screw with selfbiting conical thread and a cannula with distal holes for CSF drainage. The rate of infection was < 2% in nonseptic patients with a mean duration of the ventriculostomy of 11 days (maximum: 2 months). Hemorrhage occurred in 1% of patients. Problems were secondary wound healing after prolonged periods with ventriculostomy in place and rapid CSF-infection in cases of loosened screws which were not instantly removed. Ventriculostomy can be performed bedside within 5 min and clotted cannulas can be exchanged via the indwelling screw. The system can be resterilized and the titanium device is MRI-compatible. The method tested compares favorably with conventional techniques of external ventriculostomy. Use of the system requires continuous education of the personnel involved in order to avoid complications such as hemorrhage and loosening of the screw.

Bone Screws↗
PubMed1999

Distributions of local oxygen saturation and its response to changes of mean arterial blood pressure in the cerebral cortex adjacent to arteriovenous malformations.

BACKGROUND AND PURPOSE: To test the hypothesis that neither "steal" as cortical ischemia caused by reduced perfusion pressure nor "breakthrough" on the grounds of loss of pressure autoregulation exist in brain tissue surrounding arteriovenous malformations (AVMs), we established patterns of cortical oxygen saturation (SO(2)) adjacent to AVMs and its behavior after alterations of mean arterial blood pressure. METHODS: With a microspectrophotometer, SO(2) was scanned in the cortex around AVMs of 44 patients before and after resection and in that of a non-AVM group (n=42) before transsylvian dissection. Autoregulation was evaluated by linear regression analysis after elevation of mean arterial blood pressure (5 microg/min IV noradrenaline). SO(2) values were calculated as medians, percentage of critical values (<25% SO(2)), and coefficients of variance (approximate heterogeneity of SO(2) distributions). All values are given as mean+/-SD. RESULTS: Forty patients with AVM had an uneventful postoperative course (group A). Four hyperemic complications ("breakthrough") occurred (group B). Autoregulation was tested intact in all groups at all times. Preoperative SO(2) distributions in groups A and C (non-AVMs) were identical. In group B, significantly (P<0.05) lower medians (group A, 52.9+/-16.3%; group B, 44.2+/-17.1%; group C, 51.9+/-11.5% SO(2)), more critical values (group A, 6.5+/-5.1%; group B, 14.7+/-11.1%; group C, 7.1+/-4.9%), and heterogeneous SO(2) distributions (group A, 20.2+/-12.7%; group B, 27.9+/-12.4%; group C, 26.8+/-10.9%) were seen. Increase of median values was significantly higher in group B (76.3+/-10.4% SO(2)) than in group A (65.9+/-13.4% SO(2)) after resection. CONCLUSIONS: Severely hypoxic areas are uncommon in the cortex adjacent to AVMs and occur predominantly in patients prone to hyperemic complications. Reduced perfusion pressure is compensated in most cases, and moderate hyperemia prevails after excision. Reperfusion into unprotected capillaries of severely hypoxic cortical areas results in "breakthrough," for which vasoparalysis appears not to be the underlying mechanism.

Adolescent↗
PubMed1998

Spondylodiscitis after lumbar discectomy. Incidence and a proposal for prophylaxis.

STUDY DESIGN: An analysis of the incidence of spondylodiscitis after lumbar disc surgery in 1642 patients. In 508 patients no prophylactic antibiotics were given. In 1134 patients a collagenous sponge containing gentamicin was placed in the cleared disc space. OBJECTIVES: To report the incidence of postoperative spondylodiscitis in cases in which no antibiotic prophylaxis was used, and to define the value of a collagenous sponge containing gentamicin in preventing disc space infections. SUMMARY OF BACKGROUND DATA: Spondylodiscitis is considered to be a rare complication of lumbar disc surgery. The retrospective design of most studies and the rare use of magnetic resonance imaging for early radiologic diagnosis suggest that the reported incidence rates may be underestimates. Postoperative spondylodiscitis is the result of intraoperative contamination and, theoretically, could be prevented by treating these patients with prophylactic antibiotics. METHODS: In 1642 patients, 1712 discectomies were performed. In 508 of these patients no prophylactic antibiotics were given; in 1134 of these patients a collagenous sponge containing gentamicin was placed in the cleared disc space. Clinical reexamination and, in cases of unsatisfactory results, laboratory and radiologic investigations were performed 4-8 weeks after surgery. RESULTS: In nineteen of the 508 patients who were not treated with antibiotic prophylaxis (3.7%) a postoperative spondylodiscitis developed, whereas none of the 1134 patients who received antibiotic prophylaxis became symptomatic (P < 0.00001). CONCLUSION: In the current study, a 3.7% incidence of postoperative spondylodiscitis was found in the absence of prophylactic antibiotics. Gentamicin-containing collagenous sponges placed in the cleared disc space were effective in preventing postoperative spondylodiscitis.

Administration, Topical↗
PubMed1998

Vasospastic reactions in response to the transsylvian approach.

BACKGROUND: Cerebral vasospasm may occur with various neurosurgical procedures such as the treatment of intracranial aneurysms or of skull base tumors. This study was designed to provide more insight into the nature of vasospastic reactions in response to surgical manipulation alone. METHODS: Twenty patients who underwent selective amygdalohippocampectomy for medically intractable epilepsy using the transsylvian approach were studied prospectively. Transcranial Doppler ultrasound (TCD) was used for examination of blood flow velocities within the basal cerebral arteries before and after the operation. RESULTS: Three types of vascular reactions were observed: 1) No or only minimal reaction with increase of the blood flow velocities less than 50% as compared with the preoperative baseline values (N = 4); 2) Ipsilateral/bilateral increase of the blood flow velocities more than 50% of the baselines (N = 14); 3) Paradoxic reactions such as early postoperative resistance flow and contralateral rise of the blood flow velocities (N = 2). There was no morbidity or mortality in this series. CONCLUSIONS: The transsylvian approach is associated with significant changes in hemodynamics--partially caused by mechanical manipulation and partially by the degradation of blood--although the risk of neurological deterioration seems to be low.

Adolescent↗
PubMed1998

Physiological steal around AVMs of the brain is not equivalent to cortical ischemia.

To challenge the concept of steal rendering the surrounding cortex ischemic, we examined patterns of nutritive capillary flow in the vicinity of AVMs. With a spectrophotometer (EMPHO, BGT) capillary O2 saturation (O2 satn.) was intraoperatively scanned around AVMs in n = 44 patients and in n = 42 controls. 130,000 O2 satn. values before AVM resection were calculated as medians, ratio of critical values (< 25% O2 satn.), coefficients of variance and compared via ANOVA (p < 0.05). n = 40 AVM patients had no postoperative complication (group A), while in n = 4 cases a hyperperfusion syndrome occurred (group B). Physiological variables were comparable among groups A, B and C (controls). Medians (A: 52.9+/-16.3, B: 44.2+/-17.1, C: 51.9+/-11.5% O2 satn.) and the ratio of critical values (A: 6.5+/-5.1, B: 14.7+/-11.1, C: 7.1+/-4.9 O2 satn.) were identical in groups A and C, but significantly different in group B, indicating exhausted compensation. Decreased flow heterogeneity in group A (A: 20.2+/-12.7, B: 27.9+/-12.4, C: 26.8+/-10.9 O2 satn.) kept median cortical perfusion identical to group C. These results confirm recent findings, that cerebrovascular adaption by capillary recruitment keeps CBF at normal levels in the majority of cases and that chronic noninfarctional cerebral hypoperfusion is eventually the equivalent of steal around AVMs. Only around AVMs predisposed to hemodynamic derangement some areas of local low flow anoxia may exist.

Adult↗
PubMed1998

Significance of factors contributing to surgical complications and to late outcome after elective surgery of cerebral arteriovenous malformations.

OBJECTIVES: This study focuses on the relevance of size, eloquence, type of venous drainage, the Spetzler-Martin scale as a whole, and other factors, such as rupture of cerebral arteriovenous malformations (AVMs) for the prediction of neurological deficits in the context of microsurgical AVM removal. METHODS: One hundred and fifty patients with AVMs, whose data were retrieved from a prospectively employed computerised data bank were included. Seventeen patients (11.3%) underwent preoperative embolisation. According to the Spetzler-Martin scale they were graded as follows: 22.0% grade I, 32.0% grade II, 29.3% grade III, 14.0% grade IV, and 2.7% grade V. Intracerebral haemorrhage was present in 39.0%. The AVMs were <3 cm in 52.00/0, 3-6 cm in 43.3% and >6 cm in 4.7%; 59.3% of the AVMs were eloquently located and 29.3% had deep venous drainage (DVD). Follow up information was assessed 6 months after surgery in all but one patient, who died. The applied statistical test was chi2. RESULTS: Surgical morbidity was 15.3%. Early new deficits were noted in 39.3%, permanent new deficits in 10.6%, being significant (major) in 7.3%. The occurrence of permanent deficits correlated significantly with size, deep venous drainage, and the Spetzler-Martin scale. There was statistical evidence for a trend in risk of poor surgical outcome across the three categories non-eloquent, "less eloquent" (for example, visual cortex) and "highly eloquent" (brainstem, basal ganglia, or precentral cortex) with the last being associated with the highest risk for permanent neurological compromise. CONCLUSION: "Eloquence" of the Spetzler-Martin scale should be divided into "highly eloquent" and "less eloquent", which is important for risk analysis of the treatment of asymptomatic and deep seated AVMs and for future trials comparing various treatment modalities. In addition, resection of eloquent AVMs v non-eloquent ones is significantly associated with higher surgical morbidity.

Adolescent↗
PubMed1997

Microsurgical results for small arteriovenous malformations accessible for radiosurgical or embolization treatment.

OBJECTIVE: A consecutive series of microsurgically treated small arteriovenous malformations (AVMs), up to 3 cm in diameter, which are theoretically ideal candidates for radiosurgery or embolization, is described. We intended to elucidate the safety and efficacy of the microsurgical removal of AVMs, as compared with the results for radiosurgery and embolization reported in the literature. METHODS: Sixty-two patients (32 female and 30 male patients) ranging in age from 7 to 72 years (mean age, 33.3 yr) were included in the series. Of these, 46.8% presented with intracerebral hemorrhage and 24.2% presented with seizures. The 62 patients underwent microsurgical removal of their small (<3 cm) cerebral AVMs by the same surgeon. Twenty-six AVMs (41.9%) were assigned Spetzler-Martin Grade I, 24 (38.7%) were assigned Grade II, and 12 (19.4%) were assigned Grade III. Thirty-three AVMs (53.2%) were located in eloquent brain regions. All patients underwent postoperative control angiography and clinical follow-up after 3 and 6 months. RESULTS: The AVMs were extirpated, as confirmed by angiography, in all except one patient, thereby accounting for a 98.4% success rate per angiographic findings. The rate of immediate new postoperative neurological deficits or worsening of preexisting neurological deficits was 27.4%, and the rate of permanent significant neurological deficits was 3.2% at late follow-up. The rate of permanent significant deficits occurring after the microsurgical removal of small AVMs in eloquent regions was 6.1%. The mortality rate in the reported series was 0%. The surgical morbidity rate was 9.7%. CONCLUSION: Microsurgery for small AVMs is superior to radiosurgery or interventional neuroradiology because of its high rate of efficacy and low rate of permanent morbidity and because immediate cure of the AVMs can be achieved in the vast majority of patients. The place for radiosurgery in the treatment of small AVMs needs to be more sharply defined after careful assessment of relevant cases by an experienced vascular neurosurgeon.

Adolescent↗
PubMed1997

Can neuronavigation contribute to standardization of selective amygdalohippocampectomy?

Tailored selective amygdalohippocampal resections seem to be an interesting application for neuronavigation. The accuracy of freehand frameless neuronavigation was assessed in 28 patients for its ability to determine the hippocampal resection length, as compared to postoperative MRI. Brain collapse due to CSF displacement caused an expected error of navigation at the brain surface, but almost no error at the tentorial notch. Yet, the hippocampal resection length was overestimated by navigation to an extent of 3 +/- 2 mm. The discrepancy is explained by an anterior-posterior component of brain collapse in a tilted head. Horizontal positioning of the head or navigational marking prior to the occurrence of brain collapse may overcome the problem.

Adult↗
PubMed1997

Image guided microsurgery with a semifreehand neuronavigational device.

There is only limited experience with neuronavigators among the neurosurgical community so far. We evaluated such a prototype system in order to define indications for its succinct future use and to adjust it to daily clinical practice. We have employed an infrared light-linked computerized system (SPOCS; Aesculap/ISG) for preoperative planning and intraoperative navigation according to digitized images. A wired, penlike sensor-located "pointer" is used for navigation. Forty-eight patients (22 females, 26 males; aged 7-74 years) with a total of 53 intracranial lesions are included in the study. Fourteen lesions were smaller than 2 cm (26.4%), 33 were 2-4 cm (62.3%), and 6 were greater than 4 cm (11.3%). The documented accuracy was in the range of 3 mm or better in 33 patients throughout the whole operation and in an additional 7 through the most important surgical steps, with satisfactory results in all types of patient positioning except for the sitting position. In one patient the accuracy level decreased too early to perform useful intraoperative navigation. Technical dropouts early in the series led to abortion of the navigation in 7 instances but would currently no longer lead to abortion. There was no additional surgical morbidity associated with the use of the system. With more convenience in instrument design and development of techniques for real-time intraoperative reregistration, this kind of navigational device will play an increasingly important role for assistance during intracranial surgery. It proved to be helpful for planning of the craniotomy, intraoperative guidance on occasions of limited exposure and narrow visual field, localization and resection of small lesions in critical areas, and border definition of large lesions and for pure image guided resection of previously marked regions.

Adolescent↗
PubMed1996

Cerebral vasospasm after subarachnoid haemorrhage of unknown aetiology: a clinical and transcranial Doppler study.

Sixteen patients (6 women, 10 men; mean age: 52.5 years) suffering from spontaneous subarachnoid haemorrhage (SAH) of unknown origin underwent a protocol of initial and then weekly computed tomography (CT), initial four-vessel digital subtraction angiography (DSA) and at least one control pancerebral DSA. Fourteen patients had magnetic resonance imaging before undergoing first control DSA. All patients had calcium-antagonists (Nimodipine) via a central venous catheter, were kept on the neurosurgical intensive care unit and followed daily with transcranial Doppler ultrasonography (TCD). One patient (6.3%) developed moderate and 5 (31.1%) developed severe cerebral vasospasm as documented with TCD and exhibited deterioration of their level of consciousness. These 6 patients were treated with induced hypertension, hypervolaemia and haemodilution. Their blood flow velocities were elevated for a mean of 8 (5-17) days with a peak after 12.5 (9-17) days following SAH. No complications due to treatment were noted. One patient of the non-vasospastic group died of pulmonary embolism, another patient had an ischaemic incident during angiography, which has led to permanent disability. On follow-up 2-24 months after SAH 14 patients had returned to their premorbid state. It is concluded that patients suffering from SAH of unknown origin should undergo repeated angiographic investigation and subsequent daily monitoring of their neurologic status including daily TCD recordings so that haemodynamic treatment can be established in the event of cerebral vasospasm, which may occur in up to one third of these patients.

Adult↗