[Difference of bio-activity against regrowth bony tissue among four types of bioceramic ossicles].
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Biomedical subjects
Publications and source records attributed to C Sasaki.
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The petrosquamosal suture and septum are formed at the junction of the petrosal and squamosal bones. The suture crosses the temporal bone obliquely in an anteroposterior direction. Anteriorly, its anatomy is complex due to the convergence of two other bones: the sphenoid and the tympanic. Posteriorly, the petrosquamosal (Körner's) septum has a distinctive appearance on computed tomography (CT). While the anterior attachment of the septum can be used as a guide during surgery, the surgeon must also be aware preoperatively that large septa on CT can be mistaken for the medial mastoid wall. Prior to CT, Körner's septum has been used as a roentgenographic landmark to determine cholesteatoma extension. We now propose that the septum can also be used as a gauge for squamomastoid sclerosis.
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The pneumatization of 141 "normal" temporal bones on computed tomography (CT) was evaluated in 100 patients (age range, 6-85 years). Because of the controversy surrounding the sclerotic squamomastoid (mastoid), temporal bones with this finding were discarded. A CT index of pneumatization was based on the pneumatized area and the number of cells seen within a representative scanning section. Results suggest that squamomastoid pneumatization follows the classic normal distribution and does not correlate with age, gender, or laterality. A high degree of symmetry was found in 41 patients who had both ears examined. In 35% of all temporal bones, the petrous apex was pneumatized, concordant with the findings of other investigators. Pneumatization extending into other regions of the temporal bone corresponded linearly with squamomastoid pneumatization. Air-cell configuration was variable. Air-cell size tended to increase progressively from the mastoid antrum. The scutum "pseudotumor" appearance caused by incomplete pneumatization was seen frequently, and should not be mistaken for mastoiditis or an osteoma. Thick sections producing partial-volume effect may also produce this spurious finding. Therefore, when searching for mucosal thickening due to mastoiditis, large air cells should preferably be analyzed.
This study of 34 normal ears was conducted in order to define more precisely the normal computed tomographic (CT) anatomy of the osseous external auditory canal. Great variability was found in canal configuration and its relationship to the temporal squama. The understanding of normal CT appearance of the various fissures along the anterior wall of the external canal is important to avoid mistaking fissures for fractures.
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Sixty-five patients with suspected ear disease were examined with CT, and abnormalities were detected in 42 of them; 58 of these patients also had pluridirectional tomographic examinations. Eighteen of the patients in whom abnormalities were detected underwent exploratory surgery. CT was useful in the diagnosis of tympanic membrane swelling, fluid in the middle ear, cholesteatoma, granulation tissue, and adhesions. The superior contrast resolution of CT allowed for the visualization of ossicles when they were surrounded by an inflammatory mass or by blood. In trauma cases, axial images facilitated visualization of longitudinal fractures, which frequently pass through the geniculate ganglion of the facial nerve. CT and pluridirectional tomography were comparable in the demonstration of disease that involved the mastoid air cells, although fluid in air cells was more easily demonstrated by CT. Pluridirectional tomography was superior to CT in the demonstration of bone destruction; CT, however, was more sensitive in the diagnosis of lateral semicircular canal fistula. Based on this analysis, we recommend that these two modalities be used in a complementary fashion to evaluate suspected middle ear disease.
About 50 mg/kg of paromomycin sulfate was administered orally in a single or 2 divided doses to patients with Diphyllobothrium latum infections. The following results were obtained. After the treatment with paromomycin sulfate mature strobilae were expelled in all of 7 patients with Diphyllobothrium latum infections. We couldn't find scolices in all cases. Although these stools were examined for 2 months after the treatment, the eggs of Diphyllobothrium latum were not identified. No side effects were observed in all cases. It was concluded that paromomycin sulfate was effective on the treatment of Diphyllobothrium latum infections.
Successful temporal bone imaging demands appropriate modifications of the computed tomography (CT) scanner. While CT has been shown to be useful for demonstrating the detailed anatomy of the temporal bone, its role in the evaluation of middle ear pathology has not been investigated. Selective cases are presented to highlight the advantages of CT. Computed tomography is excellent in demonstrating soft tissue masses in the middle ear in inflammatory disease. It is also useful in accurately localizing bony fragments in trauma, as well as determining the status of the ossicles. Disease solely involving the tympanic membrane can be diagnosed on CT without subjecting the patient to surgical exploration.
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The perioperative course of three patients with obstructive sleep apnoea who underwent tracheotomy is presented as illustrative of the potentially life-threatening complications of management. It is concluded that this disease demands strict adherence to basic principles of airway management and close observation extending into the period after operation.
Three life-threatening respiratory complications are regularly encountered in patients who survive the initial insult from a diffuse brain stem lesion--central alveolar hypoventilation, upper airway obstruction, and aspiration pneumonitis. From treating 13 patients who did survive, a surgical plan for managing the respiratory sequelae of such injuries has evolved and consists of: 1)Diaphragm pacing to correct hypoventilation; 2) tracheostomy for bypass of the upper airway obstruction; 3) gastrostomy for bypass of the impaired structures of swallowing; 4) surgical closure of the larynx to prevent aspiration. All 13 patients manifested central apnea, which was controlled in five by bilateral phrenic nerve stimulation and in eight by unilateral stimulation. All patients required tracheostomy to provide an airway for artificial ventilation and for secretion removal. In ten patients aspiration necessitated gastrostomy. The spontaneous recovery of the ability to swallow allowed closure of the gastrostoma in three but in others aspiration remained a serious complication. One patient died of massive aspiration after discharge from the hospital. Three patients had surgical closure of the larynx to prevent aspiration. Seven patients are alive; six of them are leading productive lives, though several have severe disability due to paresis or ataxia. Six died after discharge from the hospital. Three deaths were not related to the basic problem but the three others may have been.
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