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Biomedical subjects

C Sanz

Publications and source records attributed to C Sanz.

100 records · Page 6Linked to original sources
PubMed1986

Hepatic disease in the Spanish toxic oil syndrome. A thirty months follow-up study.

Clinical and biological evidence of liver disease was found in 99 out of 242 (40%) patients hospitalized with acute manifestations of the Spanish toxic oil syndrome. No patient was alcoholic. According to the severity of liver involvement, patients were classified in 3 groups and followed up for at least 30 months. Group I included 65 patients with a transient increase of serum aminotransferase activity as the only evidence of liver disease. This abnormality disappeared within 2 months in all these patients. Group II included 18 patients with raised aminotransferases and alkaline phosphatase. At the end of follow-up, liver tests remained slightly abnormal in 4 patients of this group (22%) and a liver biopsy revealed minor changes in 3 of them. Group III included 16 patients with raised aminotransferases, alkaline phosphatase and bilirubin. Thirty months after the acute episode, liver function tests remained abnormal in 8 patients (50%); a liver biopsy, performed in 5 cases, showed changes suggesting chronic biliary disease in 2, and fibrosteatosis, chronic hepatitis and minimal changes in each of the remaining 3. Pulmonary, cutaneous, vascular, neuromuscular and other extra-hepatic disturbances were noted in a large number of patients but no relationship was observed between the degree of hepatic disfunction and the presence and severity of systemic manifestations of the toxic oil syndrome.

Adult↗
PubMedDate not supplied

Depression and body fat deposition in Mexican pregnant adolescents.

BACKGROUND: The objective of this study was to assess the effect of maternal depressive symptomatology on fat deposition in a group of pregnant adolescents. METHODS: A case-control study was performed with 85 pregnant women (45 adolescents and 40 adults) who attended a prenatal care course at a teaching hospital in Mexico City. During the second and third trimesters of gestation, a test proposed by Zung was applied to measure depressive symptoms. Weight and skinfolds (i.e., triceps, biceps, suprailiac, subscapular, and thigh) were measured in all women beginning at week 20 of gestation through 4 weeks postpartum. Monthly evaluations were performed. RESULTS: At the 28th week of gestation, nearly 40% of pregnant adolescents showed scores above the cut-off points in the depression test, while among the adults this proportion corresponded to 15%. In the adolescents, depression status was related to self-esteem. Percentage of body fat in adult women tended to be relatively constant, while in adolescents a tendency toward increased body fat was found. In adolescents, depressive symptomatology and especially lack of self-esteem and weight gain during pregnancy were the variables that better predicted the fat-increment pattern during gestation, while in adults no variable was found that predicted fat deposition. CONCLUSIONS: Depression status is a risk factor for excessive fat deposition during pregnancy in Mexican adolescents.

Adipose Tissue↗
PubMedDate not supplied

Involvement of insulin-like growth factor-I in inner ear organogenesis and regeneration.

The verterbrate inner ear is an excellent model system to study signalling mechanisms in embryonic development. During the last years, insulin-like growth factor-I (IGF-I) has attracted attention in relation to the regulation of inner ear ontogenesis. IGF-I and its high-affinity tyrosine-kinase receptor are expressed during early stages of inner ear development. IGF-I is a powerful mitogen for the otic vesicle, where it stimulates cell-division and mitogenic signalling cascades. Later in development, IGF-I also promotes survival and neurogenesis of the otic neurones in the cochleovestibular ganglion (CVG). The actions of IGF-I are associated with the generation of lipidic messengers and the activation of Raf kinase, which results in the rapid induction of the expression of the proliferative cell nuclear antigen (PCNA) and the nuclear proto-oncogenes c-fos and c-jun. Regulation of organogenesis involves a dynamic balance of the mechanisms regulating cell division, differentiation and death. A model is proposed where this balance is the consequence of the action of IGF-I and NGF, which converge in Raf activation or suppression. The combinatorial expression of jun and Fos family members in particular domains of the otic vesicle would be the final result of such cascade. Some of these mechanisms may be also implicated in otic regeneration.

Animals↗
PubMedDate not supplied

Active sensitization discriminates between groups of calcium antagonists in lung parenchyma strips.

When considering the therapeutic potential of calcium antagonists in asthma, attention should be paid to the existence of marked differences among these compounds. In the present study, we have compared the effect of verapamil, diltiazem, nifedipine and trifluoperazine on contractions generated by different mechanisms (CaCl2 acting on K+ depolarized preparation, depolarization by KCl, receptor activation by acetylcholine) in lung parenchyma strips isolated from control and actively sensitized guinea-pigs. It was found that verapamil and diltiazem need higher concentrations in the sensitized specimens to elicit the same degree of inhibition obtained in controls. The reverse was found for trifluoperazine while nifedipine had an intermediate position. In conclusion, acute sensitization reveals differences between the various groups of calcium antagonists in their ability to influence agonist-induced lung parenchyma strip contraction, a finding that suggests that these drugs may also behave diversely in the clinical setting.

Acetylcholine↗
PubMedDate not supplied

[Control of respiratory monitoring in the critical patient].

This study of the safety of patients undergoing mechanical ventilation was undertaken to ensure correct ventilation and to find quality-control elements for patients and nursing staff. Differences in mode programming and ventilation parameters and their registry at the change of nursing shifts, and correct programming of the sensitivity and minimum minute volume alarms and maximum airway pressure alarms were examined. In a two-month period, 8 cross-sectional studies were made of G1 prevalence in each of three nursing shifts. The status of the alarms and sensitivity were recorded when incorrect, as well as whether the ventilation mode and parameters coincided with the change of nursing shift. An analysis was made of: FiO2, PEEP, respiratory rate, minute volume, tidal volume, support pressure level, and control pressure level depending on the ventilation mode. Corrective measures were applied for a month. The effectiveness of these measures was evaluated by making 8 new G2 cross-sectional studies of the same type. Two hundred forty-eight G1 and 250 G2 recordings were made. The G2 studies revealed a generalized reduction in errors for all parameters. We concluded that the corrective measures were effective so these indicators were included in the monitoring of risk areas in the unit quality control program.

Critical Care↗