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Biomedical subjects

C Salmon

Publications and source records attributed to C Salmon.

At least 343 records · Page 19Linked to original sources
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Relationship between I and H antigens. I. A study of the plasma and saliva of a normal population.

The H and I antigens were studied in the plasma and saliva of 52 group O subjects, by hemagglutination inhibition at continuous flow. H plasma substance was detected with one anti-H antibody from a Bh donor. Secretors have more H plasma substance than do non-secretors, but there was no relationship between the amounts of I and H substances in the plasma. On the contrary, the amounts of I substance in the saliva detected by anti-I (Sti) is a function of secretor status. Nonsecretors had a much greater amount of I in saliva than did secretors. These results support the hypothesis that I antigen (detected by anti-I (Sti)) is a part of the substrate of H antigen.

ABO Blood-Group System↗
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Blood groups and genetic markers polymorphism and probability of paternity.

Recent advances in knowledge of blood groups' polymorphism provide aid to paternity diagnosis. When no exclusion is detected in any of the 20 or more systems available to the laboratory, validation of paternity is recommended. Two indices may be calculated: the proportion of males excluded by the phenotypes of the mother and child, and the probability of paternity of the alleged father. This latter index is based on bayesian process. The different formulations proposed by several authors are compared. The fact that a single exclusion in 20 or more systems needs to be denied or confirmed by indices of paternity is emphasized.

Bayes Theorem↗
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A serologic study of red cells and sera from 18 Rh:32,-46 (RN/RN) persons.

The red cells (RBCs) and sera from 18 RN/RN persons were studied. The study confirmed the Rh type D+C+E-c-e+Cw-, which is characterized by an increased expression of the D antigen; a markedly decreased expression of the C and e antigens; the presence of a low-incidence antigen, Rh32; and the absence of a high-incidence antigen, Rh46, which is associated with an epitope recognized by a murine monoclonal antibody (MR432). Other Rh antigens of low and high incidence were investigated, and the presence of Rh17 and Rh44 on the RBCs was confirmed. Three persons exposed to Rh:46 cells by pregnancy or transfusion (or both) had anti-Rh46. This antibody gave positive reactions with all RBCs of common and rare Rh phenotype except Rhnull, and those of D--, D.., DCw-, and RN homozygotes. This antibody is considered to be of clinical significance in case of transfusion or pregnancy.

Adult↗
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No evidence of frequent human immunodeficiency virus type 1 infection in seronegative at-risk individuals.

The possible existence of human immunodeficiency virus type 1 (HIV-1) infection in asymptomatic seronegative at-risk individuals was investigated in a prospective study of 55 seronegative high-risk individuals (42 homosexual men and 13 heterosexual individuals) and 32 seronegative hemophiliacs treated with factor VIII or IX concentrates before viral inactivation by heat treatment and systematic screening of blood donations. Tests used include the polymerase chain reaction assay with three primer pairs (one in the gag region and two in the pol region) and tests for serum p24 antigen, anti-nef serology (Western blot), and five biologic markers frequently altered by HIV infection (CD4 lymphocyte count, serum beta 2-microglobulin and neopterin concentration, and serum IgG and IgA concentration). Although 91 of 92 HIV-1-seropositive persons were positive in testing with at least one primer pair, no positive result was observed in seronegative at-risk individuals or in 117 seronegative low-risk controls. No nef antibody was found in seronegative at-risk individuals or seronegative controls, but 44 (47%) of 92 HIV-1-seropositive persons had nef antibodies. These findings do not support the existence of frequent HIV-1 infection in seronegative at-risk individuals.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Idiotypic specificity of a human monoclonal anti-Rhesus(D) antibody.

A human monoclonal IgG anti-Rhesus(D) (H2D5D2) obtained after transformation of lymphoid cells by Epstein-Barr virus was purified from culture supernatant by affinity chromatography. Rabbits were immunized with the monoclonal anti-D. The rabbit antisera, after appropriate absorption, reacted only against the immunizing monoclonal anti-D. The antiidiotypic antibodies (anti-id ab) were purified and gave a complete inhibition of the monoclonal anti-D, whereas no inhibition was observed with monoclonal or polyclonal IgG or with sera containing high titres of anti-D. Polyclonal anti-D obtained from 118 immunized blood donors were coated on Rh-positive red cells. Agglutination by anti-id ab was observed in 4 cases (3.4%), indicating a cross-reactivity between the monoclonal anti-D and the polyclonal anti-D present in the sera of some immunized donors.

Antibodies, Anti-Idiotypic↗
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Blood groups in Papua New Guinea Eastern Highlands.

Blood group polymorphisms were analysed in inhabitants of Papua New Guinea Eastern Highlands. The aim of the study was to assess the situation of the Baruya tribe among other Anga peoples: Youwarounatche, Andje, Usarumpia, Langimar. A non-Anga tribe, the Aziana, was also sampled. ABO, RH, MNS, P, KEL, FY and JK systems were tested in each group. ABO*O gene was predominant, ABO*Aint was relatively high, ABO*B was rare in all tribes and absent in the Usarumpia tested. The Ns haplotype was the most frequent in MNS system. All tested subjects were RH*D, KEL (-) and FY (a+b-), with very few exceptions. The presence of one CcdEe and 5 FY (a+b+) subjects may be due to foreign admixture. A noteworthy genetic microdifferentiation was observed between tribes. Geographical isolation and genetic drift has played an important role in the differentiation of the various groups.

Black People↗