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Biomedical subjects

C Saint-Maurice

Publications and source records attributed to C Saint-Maurice.

At least 109 records · Page 6Linked to original sources

[Variations of blood flow during epidural analgesia measured by a non-invasive method, i.e. transcutaneous pulsed ultrasonic Doppler velocimetry (author's transl)].

The present study aimed at appreciating the variations of femoral blood flow caused by epidural analgesia in women during delivery. In all cases the women lay supine, the cutaneous analgesia was below T 9. Bupivacaine at the average dose of 25 mg was used. Three preparations (bupivacaine 0.25 p. cent, bupivacaine 0.25 p. cent + adrenaline 1/200,000) were used. No significant variation in femoral blood flow was observed whether the solution injected contained adrenaline or not.

Anesthesia, Epidural↗

[Neuromuscular block control during and after anaesthesia (author's transl)].

During many years the clinician's requirements for neuromuscular blocking drugs are satisfied by clinical investigations. Electromyographic recordings which are a satisfactory method are not useful in current practice. The use of nerve stimulators as Churchill Davidson apparatus modified for train of four impulses must reach the continental theatres, the response to neuromuscular blocking agents varying over a wide range. Five ways of stimulation can be used giving different informations, not only during anaesthesia, but so after particularly to specify the origin of some complications.

Adult↗

[Complications following cementing of joint prosthesis].

The authors studied changes in the level of lactate dehydrogenase during insertion of hip prostheseis fixed with methyl methacrylate cement. Thirty patients were studied here. In 23 of them, the L.D.H. isoenzymes were estimated. The variations in these enzymes appear 3 hours after the second fixation with cement: rise in L.D.H., isoenzyme 5, (of skeletal muscle origin) of isoenzymes 3 and 4, (of pulmonary origin). This is a sign of pulmonary involvement even in the absence of clinical signs.

Adult↗

[2 cases of anaphylactic-type reaction related to anesthesia].

Two cases of anaphylactic shock during anaesthesia are presented, in which the etiology is confirmed by the lymphoblastic transformation test. In one case, the responsability was due to Pentothal, in the other to the combination of Pentothal-succinylcholine.

Adult↗

[Controlled hypotension during posterior vertebral arthrodesis; value of an isoflurane-nitroglycerin combination].

Eighteen young patients (mean age +/- SD 15.9 +/- 3.3) scheduled for operative treatment of idiopathic scoliosis (posterior spine fusion) were studied during surgery. Deliberate hypotension (MAP less than 60 mm Hg) of long duration (greater than 2 hours) was induced using isoflurane and nitroglycerin. Hypotension was effective in less than 15 min in all patients. The mean inspiratory fraction of isoflurane employed was 2.04 +/- 0.19% for the first operative hour, and 1.36 +/- 0.20% for the second operative hour. The difference between these inspiratory fractions is highly significant (p less than 0.001), while the rate of nitroglycerin infusion was unchanged (3 micrograms X kg-1 X min-1). Heart rate increases significantly at H1 and H2 when compared to preinduction values and the product of heart rate X systolic blood pressure decreases significantly with a mean of 30% versus preinduction values. A satisfactory operative field was obtained in all cases. Blood loss was dependent of the duration of surgery, of the total blood volume of the patient, of the length of spine fusion. For each patient, a slope of blood loss was established. The mean slope was 3.74 +/- 0.39 ml X kg-1 X h-1. The determination of the slope at the end of the first operative hour allows us to predict the total blood loss during surgery. Intra operative awakening was obtained 22.8 +/- 3.7 min after isoflurane was discontinued. Isoflurane and nitroglycerin produce a stable and safe hypotension with no major hemodynamic disturbances. Isoflurane has to be discontinued 20 min before the wake-up test.

Adolescent↗

[Effects of isoflurane administered during spontaneous ventilation in the child].

The respiratory and haemodynamic changes produced by three inspired concentrations of isoflurane (1, 1.5, and 2%) were evaluated in a healthy children (mean age 4 yrs) breathing spontaneously during anaesthesia. Isoflurane produced respiratory depression; end tidal carbon dioxide tension increased from 38.8 +/- 3.6 mmHg at 1%, to 42.6 +/- 4.3 mmHg and 48.8 +/- 4.9 mmHg at 1.5 and 2% respectively. Respiratory frequency was not modified at the different inspired concentrations of isoflurane. Heart rate and arterial pressure decreased after induction of anaesthesia with isoflurane and remained at the same level throughout the study.

Anesthesia, Inhalation↗