C Saieva — Page 3 | Search PubMed

PubMedDate not supplied

Expression of nm23 gene in gastric cancer is associated with a poor 5-year survival.

The nm23 gene is thought to play a role as an inhibitor of metastatic progression in several human cancers and its down-regulation has been associated with increased metastasis and reduced survival in some studies, though not in others. To better investigate the role of nm23 in gastric cancer (GC), the expression and prognostic impact of this gene was examined in 107 radically operated GC patients in a high risk area. The expression of nm23 was determined immunohistochemically by using the rabbit antibody anti-human nm23 protein. The expression of nm23 was detected in 40.2% (n = 43) of 107 gastric tumours and correlated with a poorer clinical outcome. In a survival analysis at 5 years, patients with nm23-positive tumours had significantly worse prognosis than patients (n = 64) with nm23-negative tumours (p < 0.05). The prognostic significance of nm23 expression was confirmed by multivariate analysis including terms for tumour stage and lymph node involvement. Our results suggest that the expression of the nm23 gene in gastric carcinoma is significantly related to tumour progression and poor prognosis at 5 years.

Adult↗

PubMedDate not supplied

Family history and risk of stomach cancer in Italy.

One thousand sixteen gastric cancer (GC) patients and 1623 population controls, interviewed in a multicentric study in Italy, reported their family history for gastric, esophageal, and colorectal cancer. A significant association was found only with a history of GC in a sibling or in a parent [odds ratio (OR), 2.6 and 1.7, respectively], which persisted after adjusting for potential confounders including nutrient intake. Adjusted GC risk was higher for subjects having an affected mother than an affected father (OR, 2.3 and 1.3) and showed a further increase for subjects reporting both parents (OR, 3.0) or two or more siblings affected with GC (OR, 8.5). The proportion of patients with an affected first-degree relative was higher among females, in the elderly, and in high-risk areas. Among adult siblings of controls and cases, GC prevalence reported at interview was 1 and 2.7%, respectively; a further increase was shown in families with at least one parent affected (1.4 and 5.7%). GC risk associated with a positive family history was greater among residents of low-risk areas where risks were increased about two-fold. Among cases, family history of GC was not related to blood group A or to histological type according to the Lauren classification. These findings are discussed in terms of the contributions of genetic and environmental risk factors and their possible interactions.

ABO Blood-Group System↗