Some drug effects on evoked cerebral potentials in man.
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Biomedical subjects
Publications and source records attributed to C SHAGASS.
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With a photographic averager to extract evoked cortical responses, reactivity cycles of primary potentials were determined over 200 milliseconds in 105 subjects. The typical cycle was biphasic, with peaks before 20 and after 100 msec. Subjects who were not psychiatric patients showed full recovery of responsiveness during the initial peak phase, whereas most of the psychiatric patients did not.
Cortical, subcortical, and peripheral sensory nerve potentials were studied in cats to determine comparative thresholds of response. Stimuli capable of eliciting responses in peripheral nerve also invariably elicited responses from thalamus and cortex. Together with relevant data from human studies, the results indicate that stimuli subthreshold for perception do not affect the nervous system. They also have implications for studies of "subliminal" perception.
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