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Biomedical subjects

C S Wilson

Publications and source records attributed to C S Wilson.

At least 55 records · Page 3Linked to original sources

Aortic stenosis and mucopolysaccharidosis.

A 43-year-old man had severe aortic stenosis and Maroteaux-Lamy syndrome (mucopolysaccharidosis, type VI). Aortic-valve replacement gave a good long-term result. Information was obtained indicating that his two brothers had also had mucopolysaccharidosis and aortic stenosis and that both had died of cardiac disease. This paper reviews the literature on cardiac involvement in mucopolysaccharidosis.

Adult↗

Acquired aortic stenosis in systemic lupus erythematosus.

Two patients with systemic lupus erythematosus had aortic valvular stenosis resulting from massive thrombotic deposits on the valve. This condition has not been described previously, but a similar process has been reported to have caused mitral stenosis in a patient.

Adult↗

Webbed penis.

Webbed penis as an isolated anomaly is rare, having been reported in 10 cases. A report is made of a 1-year-old child successfully repaired by a rectangular scrotal flap to close the penoscrotal junction and multiple W-plasty incisions for closure of the skin of the shaft of the penis.

Humans↗

Contributions of nutrition science to anthropological research.

Certain investigations of nutrition scientists have demonstrated the effects of cultural practices on nutrient intake. Anthropologists, too, have studied diets and food-related behavior, although until recently their interests infrequently included nutritional status. In the last decade, nutrition scientists' research helped stimulate the creation of an interdisciplinary specialty, nutritional anthropology, that combines techniques from both nutritional and anthropological science in the study of food use in relation to health. Practitioners of this expanding field make useful contributions to research in human nutrition through study of social aspects of the diet of individuals and groups. Their assistance can be particularly helpful in studies of populations in developing countries and of ethnic minorities in this country. Certain unanswered nutritional questions, which might more readily be solved by the combined efforts of nutritionists and nutritional anthropologists than by either professional alone, are presented.

Anthropology↗

Pelvic lymphadenectomy for the staging of apparently localized prostatic cancer.

Staging pelvic lymphadenectomy has been done on 87 patients with clinically localized prostatic carcinoma. With this method nodal metastases can be discovered, although they are undetectable by any other means. There were 44 patients with negative pelvic lymph nodes by surgical staging subjected to radical prostatectomy. Only 6 patients (14 per cent) had microscopic invasion of the prostatic capsule and there was just 1 instance of microscopic seminal vesicle invasion in those with negative pelvic lymph nodes.

Humans↗

Mid-diastolic aortic valve opening in severe acute aortic regurgitation.

A case of severe acute aortic regurgitation is reported. Echocardiographic findings included mid-diastolic opening of the aortic valve, premature closure of the mitral valve, diastolic shuddering of the anterior mitral leaflet, probable demonstration of the flail aortic cusp in the left ventricular outflow tract, and increased left atrial and left ventricular dimensions. Correlation with hemodynamic, angiographic and surgical evidence is made.

Acute Disease↗

Control of pigeons' pecking by trace stimuli.

In Experiment I, pigeons' pecking a white key was reinforced with grain when white was immediately preceded by a vertical white line on a green surround, but not by green alone. This procedure produced control of pecking by the line. Next, pecking white was reinforced after vertical line on green, but not after green alone or other orientations of the white line on green. The line-tilt dimension initially did not control pecking, a result that showed that interdimensional (line versus no line) training does not always result in dimensional control. Line-tilt control was eventually established but was accompanied by a decrease in interdimensional control. In Experiment II, interdimensional training, with or without a trace interval intervening between line on green or green alone and white, was followed by tests for line-tilt control. While interdimensional control was unaffected by the trace interval, line-tilt control tended to be less with the trace interval. This dissociation of interdimensional and dimensional control, as well as the failure of interdimensional training to produce dimensional control in Experiment I, suggests that the line stimulus is multidimensional.

Journal Article↗

Selective coronary arteriography. Risk in a community hospital.

Over a 33-month period, selective coronary arteriography was performed in 627 consecutive patients in a 385-bed, non-university-affiliated community hospital. Mortality was 0.16% (one death); there was also one nonfatal myocardial infarction. No deaths or myocardial infarctions occurred in the last 369 consecutive patients in this series when routine systemic heparinization was introduced. Substantially greater risk of mortality (2.6%) and nonfatal myocardial infarction (2.6%) was encountered in an earlier series of 78 consecutive patients for whom a different protocol was used. It included extensive exercise hemodynamic studies with the use of percutaneous arterial angiographic catheters, without systemic heparinization. This indicates that coronary arteriography can be carried out with acceptable risk in a community hospital. Protocols should be designed to minimize the time that catheters are in the arterial system. Systemic heparinization may reduce the risk of procedure-related death and myocardial infarction.

Angiography↗

Aortic root dissection: echocardiographic demon-stration of torn intimal flap.

An unusual case of aortic root aneurysm with dissection is described. A large intimal tear allowed a flap of aortic tissue to sag into the lumen. The echocardiographic and angiographic findings simulated an aortic supravalvular membrane. Surgical replacement of the aortic valve and aortic root was successfully accomplished.

Angiocardiography↗

Membranous subaortic stenosis complicated by aneurysm of the membranous septum and mitral valve prolapse.

The clinical, echocardiographic, and catheterization findings in a patient with discrete subaortic stenosis, aneurysm of the membranous interventricular septum, and mitral valve prolapse are presented. Echocardiography showed a subaortic membrane, abnormal aortic valve motion, accentuated systolic anterior motion of the membranous interventricular septum, and prolapsing mitral leaflets. Cardiac catheterization confirmed the diagnoses. The possible functional interrelationship of these lesions is discussed.

Adult↗

Correlation between segmental early relaxation of the left ventricular wall and coronary occlusive disease.

Fifty of 305 patients studied angiographically had segmental early relaxation phenomenon (SERP) of the anterolateral or apical left ventricular wall. Fourteen of the 50 patients had cardiac abnormality other than, or in addition to, coronary occlusive disease. Of the remaining 36 patients, 35 had significant lesions in the left anterior descending artery (LAD) and one had occlusion of the proximal left circumflex artery. SERP was noted in 35 (37.2 per cent) of 94 patients with LAD disease who did not have severe anteroapical contraction abnormality. SERP was found in none of 49 patients who had neither significant coronary occlusive disease nor other cardiac abnormality. Eight patients were restudied after bypass grafting of the LAD. Three patients with patent grafts no longer demonstrated SERP. Five had persistent SERP, but four of these had occluded LAD grafts or nongrafted disease in other vessels supplying the anterolateral wall. Myocardial ischemia appears to be one cause, but probably not the only cause, of SERP.

Angiocardiography↗

Bilateral arteriosclerotic coronary arterial aneurysms successfully treated with saphenous vein bypass grafting.

A man with ischemic heart disease was discovered to have bilateral coronary arterial aneurysms that were sucessfully treated with saphenous vein grafting. Preoperative coronary arteriograms revealed a tight luminal stenosis at the proximal end of the large aneurysm in the left anterior descending artery, suggesting poststenotic dilatation as an etiologic or contributing factor. The right coronary artery was totally occluded proximally, but was noted to be aneurysmal at operation. This is the 14th published case of nonfistulous coronary arterial aneurysm diagnosed in vivo, and the first associated with proximal luminal stenosis.

Arteries↗

Bilateral nonfistulous congenital coronary arterial aneurysms.

A 15 year old boy collapsed and died after participating in a basketball game. Autopsy revealed bilateral congenital coronary arterial aneurysms. The diagnosis was made post mortem but, retrospectively, might have been suspected during life, even before angiography. The clues to the correct diagnosis were chest pain, a systolic and diastolic murmur and a mass on the right heart border in the chest roentgenogram.

Arteries↗