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Biomedical subjects

C S Su

Publications and source records attributed to C S Su.

9 recordsLinked to original sources
PubMed2000

Implications of asymptomatic endocervical leukocytosis in infertility.

Genital tract infection is a known cause of male and female infertility. In this retrospective study, we investigated the effect of treatment of asymptomatic cervical leukocytosis on pregnancy rates. Twenty-five infertile women with asymptomatic cervical leukocytosis received broad-spectrum antibiotic treatment (100 mg doxycycline, 200 mg ofloxacin, and 500 mg metronidazole twice a day for 7-10 days). Pregnancy rates and resolution of leukocytosis were evaluated 6 months after treatment. Eleven patients (44%) had persistent cervical leukocytosis and 16 (64%) had become pregnant within 6 months after treatment. Successful treatment of cervical leukocytosis resulted in an increase in the pregnancy rate: 13 of the 14 patients (93%) who were cured of leukocytosis became pregnant, while 3 of the 11 (27%) who did not become pregnant were cured (p = 0.002). Patients who did not achieve pregnancy were older (p = 0. 002) than those who did. Patients who were not cured were also older than those who were (p = 0.014). Our findings suggest that the treatment for cervical leukocytosis is less effective for older patients than for younger patients. However, treatment of asymptomatic cervical leukocytosis appears to help preserve the fertility of patients with this disease.

Anti-Bacterial Agents↗
PubMed1998

Ocular anomalies in the branchio-oculo-facial syndrome.

PURPOSE: To describe the ocular anomalies in two cases of branchio-oculo-facial syndrome (BOFS). METHODS: Two cases of BOFS are reviewed. RESULTS/CONCLUSIONS: Branchio-oculo-facial syndrome is a rare branchial cleft syndrome that is characterized by a typical facial appearance of pseudo-cleft or cleft lip, subauricular branchial sinuses, deafness and ocular anomalies, which include nasolacrimal obstruction, telecanthus and colobomata. It has an autosomal dominant inheritance pattern.

Branchio-Oto-Renal Syndrome↗
PubMed1997

"Christmas eye".

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Australia↗
PubMed1994

Detection of hepatitis B virus DNA in tears by polymerase chain reaction.

OBJECTIVE: To assess the possibility of transmission of hepatitis B virus (HBV) via tears. METHODS: Tear and plasma specimens were collected from 36 carriers of HBV, and the presence of HBV DNA was investigated using the polymerase chain reaction (PCR). RESULTS: Ten (29.4%) of the 34 carriers of chronic HBV and one of the two patients with acute hepatitis B had plasma specimens that were positive for HBV DNA using PCR. Sixteen (47.1%) of the 34 carriers of chronic HBV had tear specimens that were repeatedly positive for HBV DNA using PCR, 10 (29.4%) had tear specimens that were repeatedly negative, and the remaining eight (23.5%) had tear specimens that were equivocal. Both of the patients with acute hepatitis B had tear specimens that were positive for HBV DNA using PCR. CONCLUSION: Hepatitis B virus DNA can be demonstrated in the tears of carriers, even those who were asymptomatic.

Base Sequence↗
PubMed1991

Characterization of mitochondrial DNA in various Candida species: isolation, restriction endonuclease analysis, size, and base composition.

A practical and effective method for the extraction of mitochondrial DNA from Candida species was developed. Zymolyase was used to induce yeast protoplasts, and mitochondrial DNA was extracted from DNase I-treated mitochondrial preparations. Restriction endonuclease analyses of mitochondrial DNAs from 19 isolates representing seven species of Candida (C. albicans, C. kefyr, C. lusitaniae, C. maltosa, C. parapsilosis, C. shehatae, and C. tropicalis) and Lodderomyces elongisporus revealed different cleavage patterns that appeared to be specific for the species. Few common restriction fragments were evident. The genome sizes of the mitochondrial DNAs ranged from 26.4 to 51.4 kilobase pairs, and the guanine-plus-cytosine contents ranged from 20.7 to 36.8 mol%. There was no correlation between the base compositions of nuclear and mitochondrial DNAs. Eight isolates of C. parapsilosis, including the type culture, and an ascosporogenous strain of L. elongisporus, which was once proposed as the teleomorph of C. parapsilosis, had similar mitochondrial DNA molecular sizes (30.2 and 28.8 kilobase pairs); however, restriction endonuclease patterns of these organisms were distinct. These data provide additional support for discrimination of these two species. The results of our experiments demonstrate that mitochondrial DNA analyses may provide useful criteria for the differentiation of yeast species.

Base Composition↗
PubMed1989

Restriction endonuclease analysis of mitochondrial DNA from Candida parapsilosis and other Candida species.

Mitochondrial DNA has been studied in a number of eukaryotic organisms. Differences in inter- and intraspecies mitochondrial DNA restriction patterns have been shown to be due to differences in nucleotide sequences and have been used to study evolutionary relationships and the mode of inheritance of the mitochondrial genome. A relatively rapid and efficient method for the extraction of mitochondrial DNA from Candida parapsilosis and other Candida species was developed. Zymolyase was used to induce yeast protoplasts and mitochondrial DNA was extracted from DNase I-treated mitochondrial preparations. Digestion with the restriction endonucleases Eco RI, Hind III and Bam HI yielded the most definitive restriction patterns. The results of the restriction endonuclease analysis were in agreement with the current identification of these organisms. Candida parapsilosis, Candida albicans and Candida kefyr showed different restriction patterns. Eight Candida parapsilosis strains were compared and all had identical fragment patterns. The molecular size was approximately 30 kilobase pairs and the GC content was 33.2%. The results of these experiments demonstrate the potential of a simple molecular technique for the differentiation of yeast species.

Base Composition↗