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Biomedical subjects

C S So

Publications and source records attributed to C S So.

At least 37 records · Page 2Linked to original sources

[Early arteriosclerosis with increased thrombocyte aggregation (author's transl)].

The importance of thrombocyte function in atherogenesis is discussed in the light of experimental and clinical results. Adhesion and aggregation of thrombocytes on an intact or injured artery wall may be the first step to atherosclerotic plaque. In vitro measurements of aggregation, in vivo measurements of thrombocytic survival time and microscopic and histological examinations are all consistent in showing a rise in aggregation of thrombocytes in the early stages of arteriosclerosis. The measurement of thrombocyte function is therefore recommended in addition to the known risk factors in patients with a greater risk of arteriosclerosis.

Animals↗

[Clinical pictures of hemiblock and fascicular block. Diagnosis and clinical significance].

In intraventricular conducting defects distal the bundle of His we see different forms, i.e. left anterior and left posterior hemiblock, left bundle branch block and right bundle branch block. The left anterior hemiblock is electrocardiographically responsible for a left axis deviation, the left posteriof hemiblock for a vertical axis or right axis deviation. If there is in addition to a hemiblock a right bundle branch block, it is called a bifascicular block. Are at the same time all three fascicles concerned, there will be a trifascicular block, i.e. a complete atrioventricular block, the so-called peripheral form. The common cause of fascicular blocks is coronary heart disease. Because of the possible progressing of the disease patients need further surveillance and eventually therapy.

Age Factors↗

[Treatment of bradycardiac arrhythmias with depot-orciprenaline (author's transl)].

24 patients with bradycardiac arrhythmias of various origin were treated with a new depot preparation of orciprenaline. The special galenical preparation guarantees effectiveness ofr 8-10 hours. In 21 patients (87%), therefore, one dragee morning and evening was sufficient to obtain a mean rise in frequency of 57%. The preparation had to be discontinued in 3 cases because of side effects such as increase in ventricular extrasystoles, anginal complaints and critical rise of blood pressure in hypertension. Because of its trouble-free administration in a depot form the preparation not only offers a practical advantage over the short-acting commercial preparations, but also shows a reliable efficacy. It can therefore be given under regular supervision in all forms of bradycardiac arrhythmias with stable ventricular frequency and satisfactory cardiac output.

Aged↗

Vectorcardiographic findings in Friedreich's ataxia.

Cardiac manifestations in Friedreich's ataxia occur frequently. We have studied 17 cases of Friedreich's ataxia, of which 94% showed a disturbance of the repolarization in the scalar ECG, 29% showed evidence of left ventricular hypertrophy. These changes are not specific but typical of Friedreich's ataxia. Vectorcardiograms were taken with the Frank-system. The vectorcardiographic findings showed not only the same changes as seen in the sclar ECG, but furthermore an atypical configuration of the QRS-loop was evident, which was not recognized in the scalar ECG. According to our experience compared with the scalar ECT, the vectorcardiographic investigations can be considered a more useful method in the diagnosis of Friedreich's ataxia.

Adult↗

[Electrocardiographic changes in electrolyte inbalance. Part 2: Alterations in serum calcium (author's transl)].

74 patients (hypocalcemia: 41 patients, hypercalcemia 13 patients, 20 patients as control) without heart disease were examined. A prolongation of the relative QT-interval was found in 90% and a flat or inverted T-wave in 25% of the patients with hypocalcemia. In 77% of the patients with hypercalcemia the QT-interval was shortened. A good, clinically useful correlation between the QT-interval and the serumcalcium-concentration could be established in patients with hypo- and hyper-calcemia.

Action Potentials↗