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Biomedical subjects

C S Seah

Publications and source records attributed to C S Seah.

52 records · Page 3Linked to original sources
PubMed1973

Chronic liver disease: differences in autoimmune serological reactions between Australians and Asians.

A total of 164 patients from Australia, Ceylon, India, Singapore, and Thailand were studied for the prevalence of autoantibodies associated with "idiopathic" chronic liver disease-namely, antinuclear antibody, smooth muscle antibody, and mitochondrial antibody. The prevalence of these autoantibodies was high among patients from Australia (55%), but was low among patients from Ceylon (14%), India (11%), Singapore (0%), and Thailand (8%). There are variations in types of hepatitis and cirrhosis between races, and this applies particularly to the type associated with autoimmune markers. This may be related to genetic differences that have evolved between peoples of European and Asian descent.

Antibodies, Antinuclear↗
PubMed1973

Cyclophosphamide in treatment of systemic lupus erythematosus: 7 years' experience.

This paper describes our experience with cyclophosphamide in the treatment of systemic lupus erythematosus. Since 1965 42 such patients have been treated either singly with cyclophosphamide or in combination with steroid. Serious complications have been rare except for amenorrhoea, which occurred in 14 out of 32 patients within the reproductive period. Our experience suggests that cyclophosphamide has an important, though not primary, part to play in the therapy of this disease.

Administration, Oral↗
PubMed1971

Comparison of median and ulnar sensory nerve action potentials in the diagnosis of the carpal tunnel syndrome.

Recording of median and ulnar digital sensory nerve action potentials in normal subjects showed that the ratio of the median (index finger) to ulnar (little finger) potential amplitude was consistently greater than one. In 15 patients with the carpal tunnel syndrome (seven bilateral) this ratio was found to be less than one for all but two of the 22 clinically affected hands, including three of the four hands with a normal motor latency to threshold stimulation and four of the five hands with a normal sensory conduction. It is concluded that the estimation of the ratio of the median to ulnar sensory potential amplitude is a sensitive test in the diagnosis of the carpal tunnel syndrome and is particularly useful in those patients who show a normal motor latency and sensory conduction.

Action Potentials↗
PubMedDate not supplied

The prognosis of chronic active hepatitis without cirrhosis in relation to bridging necrosis.

Sixty-nine patients with chronic active hepatitis without cirrhosis were studied to define the prognostic implications of bridging necrosis of various types. There were 19 patients without bridging necrosis compared with 50 patients with bridging necrosis. The two groups did not differ significantly at presentation in age, sex, clinical or laboratory features. In the group without bridging necrosis, no patient died from the disease and none of 13 having a later biopsy developed cirrhosis. In the group with bridging necrosis, one patient died from hepatic failure and 7 of 36 developed cirrhosis (19%). When analyzed statistically, a significant (p less than 0.05) relationship is seen between increasing severity of initial lesion and the subsequent development of cirrhosis. It is concluded that patients with piecemeal necrosis without bridging should not be grouped together with patients with bridging necrosis or cirrhosis when considering management decisions.

Adolescent↗