Biomedical subjects
C S Rao
Publications and source records attributed to C S Rao.
Acetic acid and phenylquinone writhing test: a critical study in mice.
Studies were planned to establish the dose-effect relationship with both acetic acid and phenylquinone and to find out suitable concentrations for these two chemicals for pre- and post screening. The LD50 of acetic acid and phenylquinone were found to be 3.16% and 0.23%, respectively. Based on the studies conducted, the prescreening and postscreening concentrations of 0.5% is recommended for acetic acid, while for phenylquinone, prescreening concentration of 0.005% and postscreening concentration of 0.02% is advocated. Using this criterion in the acetic acid writhing test, analgin was the most potent analgesic while aspirin was the least. However, suprofen was most potent and paracetamol least among analgesics employed against phenylquinone induced writhing.
[Whole soy bean flour: use of a methodology of response surface for the study of nutritional aspects].
Cotyledons of soybeans (Glycine max) of the Paraná variety were subjected to hydrothermal processing. Response surface methodology was used to evaluate the conditions which provided a product of the highest protein quality. The processing variables used in the experimental design were: soaking time (0 - 8 hr); blanching time (5 - 35 min) and bicarbonate concentration (0 - 0.5 g%) in blanching water. Biological evaluations of protein quality were done using the NPR. The mathematical model developed does not distinguish between treatments (p less than 0.05) in the experimental region studied.
A case of factor XIII deficiency in an adult male.
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Ambiguous genitalia in a male infant with persistent Mullerian structure syndrome.
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Effects of maternal anti H-Y antibodies on fetal gonadal development.
C57BL/6 inbred female mice preimmunized by serial injections of isogeneic male spleen cells were mated and the effects of the circulating anti H-Y antibodies on the fetal gonads and on their fertility were studied. Female mice receiving injections of saline formed one control group and those given female spleen cells a second control group. The experiment was carried out three times and since observations were similar and reproducible the data of all three sets were pooled. There was no significant change in the birth weights of newborns, total number of conceptions or sex ratio in the study group compared to either of the controls. There was no difference in the mean live birth rate between the study group and both the controls. Although the incidence of stillbirths in the study group was higher than that in both controls the difference was not statistically significant. In the study group there were no histopathological changes in the gonads from female pups compared to ovaries from the controls. In contrast, the gonads of male pups showed mild to severe structural disorganization in the study group, but not in the female spleen cell injected group. In spite of the morphological changes in the testes, the newborn male pups had a normal anogenital distance and testicular descent suggesting that Leydig cell function was normal.
Role of H-Y antigen in gonadal differentiation.
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Familial occurrence of trophoblastic disease - report of recurrent molar pregnancies in sisters in three families.
Three families are described in which trophoblastic desease occurred in one or more pregnancies in two or more sisters. The possible role of genetic factors in the etiopathogenesis of hydatidiform mole is reviewed in light of these data. We believe this to be the first report of familial occurrence of molar pregnancies.
ABO blood groups and fertility--with special reference to intrauterine selection due to materno-fetal incompatibility.
The purpose of the present investigation was to study whether there is differential fertility between different mating types of ABO blood group system. Selective force which is operating through maternal-fetal incompatibility has been observed in the differential fertility between compatible and incompatible mating groups in the present sample of 183 families of Visakhapatnam town of Andhra Pradesh,India. The differences in the mean numbers of pregnancies as well as living children between the two major mating groups, compatible and incompatible are significant. The fertility rates of O fathers and O mothers were significantly higher than those in matings in which neither parents belongs to O. The selection is operating to reduce the gene ratio of A and to increase the gene ratios of O and B in this sample.
Effect of three antagonists on the development of bacterial leaf streak of rice.
Among 11 epiphytic microorganisms one species each of Pseudomonas, Erwinia, and Aspergillus were antagonistic to Xanthomonas translucens subsp. oryzicola. Symptoms of bacterial leaf streak did not develop when the antagonists were sprayed on rice leaves 24 h before inoculation. Although the symptoms developed when the antagonists were applied 24 h after inoculation, the number of lesions and their length was significantly reduced over control. When the mixture of each antagonist and the pathogen was applied, no symptoms developed with Pseudomonas and Aspergillus sp. However, the symptoms could develop with Erwinia sp. although the number and length of the lesions was reduced over control.
Nodular goitre in northern India : a clinicopathological profile.
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Evaluation of betamethasone and isoniazid along with chloramphenicol in the management of whooping cough.
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The complications of enterocolitis.
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Oestrus in village herds of Indian water buffaloes.
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Pulmonary alveolar microlithiasis.
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Establishment and characterization of a paclitaxel-resistant human non-small cell lung cancer cell line.
We have established a paclitaxel-resistant mutant cell line called H460/TAX which was derived from human non-small cell lung cancer (NSCLC) H460. A 64-fold greater resistant was shown in our assay as compared with the parental cells. High specificity of drug resistance was also observed since this mutant was not cross-resistant to several other anticancer drugs. Drug accumulation in H460/TAX was significantly less than that in H460. Many endogenous protein profiles were intact, including the expression level of P-glycoprotein, multidrug resistance-associated protein, the 70 kDa heat shock proteins as well as the phosphorylation of Bcl-2 in H460/TAX cells, except that the total amount of alpha- and beta- tubulins was higher in H460/TAX than in H460 cells. Higher drug concentration and longer treatment for paclitaxel were required in H460/TAX to exert the phosphorylation of keratin 19 which was then accompanied by reorganization of the intermediate filament and the microtubule networks. Since all of the aforementioned factors involved in paclitaxel-resistance in other systems were not found to be significantly altered in H460/TAX, there must be other paclitaxel-resistance mechanisms(s) which remains to be identified in human lung cancers.
Activity of some anti-inflammatory agents against carrageenin-induced pedal oedema in mice.
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