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Biomedical subjects

C S Feng

Publications and source records attributed to C S Feng.

At least 37 records · Page 2Linked to original sources
PubMed1991

Bone marrow findings in lupus patients with pancytopenia.

The marrow findings of 23 lupus patients with pancytopenia were reported. The most common findings were dyserythropoiesis and hypoplasia, both occurring in 9/23 (39%) of the cases. Neither feature was definitely related to cytotoxic drug therapy since most cases were treated by steroids only. Three of the hypoplastic marrows also showed gelatinous transformation, a condition characterized by disruption of marrow architecture, fat atrophy, and deposition of hyaluronic acid. Another common finding was lymphocytosis which occurred in 5/23 (22%) of the cases, 2 of which also had associated plasmacytosis. Two cases were associated with hyperplastic marrow, indicating peripheral destruction of blood cells and compensatory marrow hyperplasia. Reports in the literature on bone marrows in systemic lupus erythematosus are conflicting, describing mainly hypoplasia, vasculitis, plasmacytosis, red cell aplasia, and myelofibrosis. In our series, we found hypoplasia and lymphocytosis/plasmacytosis; in addition we described findings previously unreported: gelatinous transformation, dyserythropoiesis, and marrow hyperplasia.

Bone Marrow↗
PubMed1991

An analysis of donor blood wastage due to outdating in a large teaching hospital.

We analyzed the pattern and rate of donor blood outdating in our hospital from 1986 to 1990. We found that there was a sharp drop in blood outdating since the implementation of the Type and Screen crossmatch protocol. The outdating rate was reduced from 11.5% to 1.3% for whole blood and from 4.9% to 0.4% for red cells. In absolute numbers, wastage of blood due to outdating was cut from 2,570 units in 1986-87 (a 2 yr period before Type and Screen) to only 227 units in 1988-89 (a 2 yr period after Type and Screen). We also found that the outdating rate varied among different blood groups (group 0 less than A = B less than AB), and the outdating of whole blood was consistently more than red cells throughout the study period. The results of our utilization review were conveyed to local hospitals and the blood supplier in an effort to preserved donor blood.

Blood Donors↗
PubMed1990

Intranuclear inclusions in myeloma cells in a case of nonsecretory multiple myeloma.

Inclusions in the nucleus, compared with those in the cytoplasm, are rare in myeloma cells but have been reported in all electrophoretic varieties of multiple myeloma except the nonsecretory type. In this unusual case, a 54 year old Chinese woman had a pathological fracture of the left femur, and biopsy of the fracture site revealed a round cell tumor compatible with plasmacytoma. A bone marrow aspirate revealed 50% plasma cells, many of which contained intranuclear inclusions. Protein electrophoresis was normal with no paraprotein, and urine was free from Bence-Jones protein. Under electron microscopy, the plasma cells showed electron-dense spherules not circumscribed by a membrane. The absence of a membrane was unusual, because according to all reported cases, these intranuclear inclusions were invariably membrane-bound. The association of nonsecretion of paraprotein in myeloma, which is rare, and the absence of a membrane enclosing the intranuclear inclusions, which is heretofore unreported, is probably not coincidental but causally related in that paraprotein produced in the nucleus of myeloma cells (stored in the form of intranuclear inclusions) fails to be detected in serum and urine because of noninteraction between these inclusions and the membranes of the nucleus and endoplasmic reticulum.

Cell Nucleus↗
PubMed1990

Incidence of ABO haemolytic disease of the newborn in a group of Hong Kong babies with severe neonatal jaundice.

Two methods were used to determine the incidence of ABO haemolytic disease of the newborn (ABO-HDN) among Hong Kong Chinese infants. The first method employed the Lui elution technique to elute anti-A,B from cord blood of Group A and B babies with a Group O mother, and set out to correlate the titration score of the eluate with the serum bilirubin of the neonates. This method proved to be a failure because of the poor correlation. The second method was mathematical. By comparing the 'expected' frequency of various mother-infant ABO combinations (based on the ABO distribution of our local population) with the 'observed' frequency of a cohort of infants with severe neonatal jaundice, it was found that only two combinations (O-A and O-B mother-infant pairs) were responsible for ABO-HDN, for which the incidence was 1 in 5 among infants with a serum bilirubin level of 300 mumols/L or more.

ABO Blood-Group System↗
PubMed1990

Use of peripheral vessels for exchange transfusion.

During a five and a half year period, exchange transfusions were performed through the peripheral vessels in 201 of the 214 infants (94%) who required either double volume or partial plasma exchange transfusions. Peripheral vessel exchange transfusion is simple, practicable, and safe with few complications. Technical difficulties in catheterizing the peripheral artery and vein may be overcome by using a 24 gauge catheter, which causes no more catheter induced haemolysis than standard umbilical catheters.

Bilirubin↗
PubMed1990

Fibrinogen level in health and disease.

The plasma fibrinogen concentration of 47 healthy individuals was measured in order to determine the reference range for our laboratory, which was calculated to be 1.75-3.31 g/l. The plasma fibrinogen concentration of 44 hospital patients was also measured for comparison. These patients were selected because they were free from bleeding tendency and liver disease. The distribution of their fibrinogen levels was Gaussian, but more wide-based than the distribution of our normal controls. The mean fibrinogen value of the patient group was 3.60 g/l, significantly higher than that of the healthy group, which was 2.53 g/l. The reasons why the fibrinogen distribution graph of patients assumed such a pattern and the role of fibrinogen in health and disease are discussed.

Fibrinogen↗
PubMed1989

A survey of fresh frozen plasma use in a teaching hospital in Hong Kong.

In response to an acute shortage of fresh frozen plasma (FFP), a survey of its use was conducted in our hospital. The survey was designed to separate the use of FFP into "appropriate use" and "inappropriate use" categories. Whether the use of FFP in a case could be assigned to "appropriate use" category or not was decided by pre-set criteria based on the consensus statement published by the United States National Institute of Health (NIH). We found that during a 30-day period, out of 746 units of FFP used, only 65 (8.7%) could be considered inappropriate use. Most of the FFP (67.6%) was used for liver disease with bleeding and/or abnormal coagulation tests, and for disseminated intravascular coagulopathy. In the "inappropriate use" category (8.7%), the leading causes were plasmapheresis, and hepatobiliary disease with normal coagulation tests and no abnormal bleeding.

Blood Transfusion↗
PubMed1989

Megakaryoblastic transformation of a myeloproliferative disorder.

A case of megakaryoblastic transformation of a myeloproliferative disorder presenting initially as chronic granulocytic leukaemia with an intermediate phase of essential thrombocythaemia in a Chinese woman of 65 years is reported. The diagnosis of megakaryoblastic crisis was based on morphological, cytochemical and immunocytochemical features present in blast cells in the blood, together with cytochemical and ultrastructural features of micromegakaryocytes and megakaryoblasts which were predominant in the marrow. A literature review showed newer refinements in diagnosis such as ultrastructural platelet peroxidase and additional immunologic techniques employing antisera against further platelet products. The response to treatment remains uniformly poor.

Aged↗
PubMed1989

[Prophylactic effects of Salvia miltiorrhizae and ligustrazine on experimental respiratory distress syndrome induced by oleic acid in rats].

The prophylactic effects of Salvia miltiorrhizae and ligustrazine on experimental respiratory distress syndrome (RDS) in Wistar rats were observed and compared with the dexamethasone. Sixty-two male rats weighing 194.68 +/- 20.40 g (M +/- SD) were used in this experiment. The rats were randomly divided into five (A-E) groups. Group A was given normal saline 0.1 ml/kg alone and group B oleic acid 0.1 ml/kg; both were injected in tail vein, and the latter produced typical RDS. Group C, D, E were injected intraperitoneally with agents of dexamethasone 2 mg/kg, Salvia miltiorrhizae 1.5 g/kg, and ligustrazine 20mg/kg, respectively, 15 minutes before oleic acid intravenous injection. All of the animals were sacrificed quickly 6 hours after injections and lung tissues were taken and examined with light and electronic microscope. The results showed that all of these medicines could minimize the lesions caused by oleic acid. Lung/body index was reduced. Prophylactic effects of Salvia miltiorrhizae and ligustrazine were similar to dexamethasone. The authors considered that preventive use of Salvia miltiorrhizae or ligustrazine could protect the lung from the development of RDS.

Animals↗
PubMed1989

Gelatinous transformation of bone marrow in systemic lupus erythematosus.

Gelatinous transformation of marrow is a rare disease entity described in cachexia and various other disorders. Its association with systemic lupus erythematosus (SLE) has never been reported. We found gelatinous transformation in 3 of 30 patients with SLE with pancytopenia. Two of these patients were cachetic, one of whom also had active tuberculosis. We propose that gelatinous transformation can be associated with SLE, and its detection calls for an evaluation of nutritional status, and a search for chronic debilitating infections such as tuberculosis.

Adult↗
PubMed1988

An unusual case of extramedullary blast crisis in chronic myelocytic leukaemia.

A 27-year-old man with chronic myelocytic leukaemia sustained two episodes of extramedullary blast transformation. The first episode was a lymphoblastic transformation in his cervical lymph nodes, which was treated and in remission for 15 months when a second blastic transformation occurred in the meninges. All the while, the bone marrow was free from blastic crisis.

Adult↗
PubMed1988

Juvenile chronic myeloid leukemia. A malignancy of S-100 protein-positive histiocytes.

Three cases of juvenile chronic myeloid leukemia (JCML) are reported. The patients were aged 3-4.5 years and presented with generalized lymphadenopathy, hepatosplenomegaly, anemia, thrombocytopenia, elevated white blood cell count with monocytosis, and high fetal hemoglobin level. Philadelphia chromosome was absent in two cases studied. The bone marrow showed myeloid hyperplasia with increased monocytoid cells and blasts. Biopsy or postmortem material available in two cases revealed malignant infiltration of lymph nodes, liver, spleen, lungs, intestines, and skin. The neoplastic cells ranged from cells with irregular nuclei possessing nuclear grooves to large blastic cells with round to lobulated nuclei and prominent nucleoli. They showed weak staining for acid phosphatase and nonspecific esterase and exhibited the immunophenotype EBM11+KiM1+KiM6+KiM8+CD4+HLADR+ S-100 protein+. The neoplastic cells of JCML therefore share features of dendritic cells and mononuclear phagocytes. The authors' findings show that JCML is a unique histiocytic malignancy in which S-100 protein is a useful marker.

Blood Cells↗
PubMed1984

Multilocular renal cyst.

A case of multilocular renal cyst histologically consistent with clear cell carcinoma is reported. This case is unusual in that the cyst had features indicative of a developmental malformation superimposed by a neoplasm. The controversy over the pathogenesis of multilocular cyst--neoplasm versus developmental anomaly--is unsettled. This case illustrates the possibility that multilocular cysts can be developmental defects which subsequently become the origin of neoplastic transformation of the dysgenetic tissue.

Adenocarcinoma↗