Biomedical subjects

C S Dodson

Publications and source records attributed to C S Dodson.

10 recordsLinked to original sources

PubMed2001

Misattribution, false recognition and the sins of memory.

Memory is sometimes a troublemaker. Schacter has classified memory's transgressions into seven fundamental 'sins': transience, absent-mindedness, blocking, misattribution, suggestibility, bias and persistence. This paper focuses on one memory sin, misattribution, that is implicated in false or illusory recognition of episodes that never occurred. We present data from cognitive, neuropsychological and neuroimaging studies that illuminate aspects of misattribution and false recognition. We first discuss cognitive research examining possible mechanisms of misattribution associated with false recognition. We also consider ways in which false recognition can be reduced or avoided, focusing in particular on the role of distinctive information. We next turn to neuropsychological research concerning patients with amnesia and Alzheimer's disease that reveals conditions under which such patients are less susceptible to false recognition than are healthy controls, thus providing clues about the brain mechanisms that drive false recognition. We then consider neuroimaging studies concerned with the neural correlates of true and false recognition, examining when the two forms of recognition can and cannot be distinguished on the basis of brain activity. Finally, we argue that even though misattribution and other memory sins are annoying and even dangerous, they can also be viewed as by-products of adaptive features of memory.

Amnesia↗

PubMed2001

Extra-hepatic expression of serum albumin mRNA in mouse retina.

PURPOSE: In some mammals, serum albumin protein exists in the interphotoreceptor space (IPS), the space between photoreceptor cells and the retinal pigment epithelium. Serum albumin is synthesized largely in the liver, though low levels of extra-hepatic expression have been documented in several other tissues, including fetal rat kidney, pancreas, lung, and heart. The purpose of this study was to investigate whether serum albumin protein and mRNA are found in mouse retina. METHODS: Using albumin rabbit antibodies and HRP goat anti-(rabbit IgG), we performed immunoassays on mouse IPS washes to detect the presence of serum albumin protein. Protein extracts from IPS washes were subjected to Affigel Blue chromatography. This resin has an affinity for serum albumin. Reverse transcription-polymerase chain reaction (RT-PCR) of retina total RNA was performed to search for albumin mRNA. Also, real-time reverse transcription polymerase chain reaction (RT-RT-PCR) was employed to look at the levels of expression in different age groups. RESULTS: A constituent of the IPS washes specifically bound and eluted from Affigel Blue column, suggesting that the washes contained serum albumin. SDS PAGE revealed that the size of the constituent was 67 kDa, the size of serum albumin. This 67 kDa band reacted with mouse serum antibody. An RT-PCR amplified fragment of serum albumin mRNA from retina displayed the expected size. The sequence of this fragment is identical to authentic serum albumin cDNA sequence. RPE and choroid were negative for serum albumin mRNA. However, rd1(-)/rd1(-) retina was positive, suggesting that at least some serum albumin is synthesized in the inner layers of the retina. RT-RT-PCR showed that serum albumin mRNA levels in whole retina reached a maximum at about postnatal day 15 and gradually decreased to about one-sixth of maximum at 12 months age. CONCLUSIONS: Serum albumin protein and mRNA were found in mouse IPS and retina, suggesting that the protein is synthesized in the retina. The previously demonstrated ability of serum albumin to bind fatty acids and retinoids and its presence in the mouse IPS suggest a role for serum albumin in transporting retinoids in the retina or IPS, especially at young ages when concentrations appear greatest.

Animals↗

PubMed2001

"If I had said it I would have remembered it": reducing false memories with a distinctiveness heuristic.

We examined the contributions of decision processes to the rejection of false memories. In two experiments, people studied lists of semantically related words and then completed a recognition test containing studied words, unrelated lure words, and related lure words. People who said words aloud at study were less likely to falsely recognize related lures on the test than were those who heard words at study. We suggest that people who said words at study employed a distinctiveness heuristic during the test whereby they demanded access to distinctive say information in order to judge an item as old. Even when retrieving say information is not perfectly diagnostic of prior study, as in Experiment 2, in which participants both said and heard words at study, people persist in using the distinctiveness heuristic to reduce false memories.

Adult↗

PubMed2001

Retrieval conditions and false recognition: testing the distinctiveness heuristic.

High levels of false recognition are observed after people study lists of semantic associates that all converge on a nonpresented lure word. In previous experiments, we have found that orienting participants to encode distinctive information about study list items by presenting them as pictures as opposed to words produces marked reductions in false recognition. We have suggested that these reductions reflect the operation of a distinctiveness heuristic: Participants demand access to detailed pictorial information in order to support a positive recognition decision. The present experiments provide additional evidence on this point and allow us to distinguish between the distinctiveness heuristic account and an alternative account based on the impoverished encoding of relational information that occurs when one is studying pictures. In Experiment 1, even when only half of the items in a study list were presented as pictures, a general suppression of false recognition was observed that could be attributable to impoverished encoding of relational information. Experiment 2 provided a critical test of the distinctiveness heuristic account: We manipulated test instructions and found that differences in false recognition rates between picture and word encoding were attenuated in a retrieval condition that did not encourage reliance on a distinctiveness heuristic.

Association↗

PubMed2000

Differential effects of cue dependency on item and source memory.

The authors investigated the cue dependency of source and item memory. Individuals listened to words spoken by a man or a woman and later determined whether a test word was previously presented by a man or by a woman, or whether it was a new word. Cue dependent effects were assessed by presenting test words with (a) the same voice (match condition) that originally presented the word, (b) a different but familiar voice (mismatch condition), (c) a novel test voice (novel condition), and (d) no test voice (control condition). Compared with the control condition, source recollection was facilitated in matching-context conditions, disrupted in mismatching-context conditions, and not affected in novel test conditions. By contrast, item recognition was not affected by the match-mismatch manipulation but was significantly worse in novel test voice conditions. The authors propose an associative source interference view to account for the voice match-mismatch effects observed in source recollection.

Cues↗

PubMed2000

An analysis of signal detection and threshold models of source memory.

The authors analyzed source memory performance with an unequal-variance signal detection theory model and compared the findings with extant threshold (multinomial and dual-process) models. In 3 experiments, receiver operating characteristic (ROC) analyses of source discrimination revealed curvilinear functions, supporting the relative superiority of a continuous signal detection model when compared with a threshold model. This result has implications for both multinomial and dual-process models, both of which assume linear ROCs in their description of source memory performance.

Adolescent↗

PubMed1998

On the recollection of specific- and partial-source information.

Memory judgments can be based on information that is more or less specific with respect to the source of an item. The authors introduce a procedure and multinomial model for measuring specific- and partial-source information. In 2 experiments, participants heard words spoken by 4 different voices: 2 male voices and 2 female voices. During the test, participants were required to remember who spoke the test items (e.g., Male 1, Male 2, Female 1, Female 2, or new word). Participants often remembered information about the gender of the source (i.e., partial-source information) when they did not remember information that identified the source itself (i.e., specific-source information). Dividing attention during retrieval impaired participants' memory for specific-source information (i.e., voice information) but did not affect memory for partial-source information (i.e., gender information).

Attention↗

PubMed1997

The verbal overshadowing effect: why descriptions impair face recognition.

Three experiments explored the verbal overshadowing effect, that is, the phenomenon that describing a previously seen face impairs recognition of this face. There were three main results: First, a verbal overshadowing effect was obtained both when subjects were provided with and when they generated a description of an earlier seen face. Second, instructing subjects at the time of test to be aware of potentially competing memories did not improve, and may even have worsened, recognition performance when the subjects had generated a description of the target face. However, these instructions improved performance and eliminated the verbal overshadowing effect when subjects were provided with someone else's description of the target face. Third, recognition of the target face was disrupted when subjects described a completely different face, such as their parent's face or a face of the opposite sex. The results are discussed in relation to two potential mechanisms: source confusion between previously encoded visual and verbal representations of the face and a shift in processing of the test faces at recognition.

Analysis of Variance↗

PubMed1996

Some problems with the process-dissociation approach to memory.

The process-dissociation framework (L. L. Jacoby, 1991) is a technique for deriving estimates of controlled (e.g., recollection) and automatic (e.g., familiarity) memory processes. The authors examined 3 assumptions of this framework. In Experiment 1, estimates of familiarity were affected by varying the proportion of old targets to old nontargets on the inclusion and exclusion tests and whether or not the tests were completed with full or divided attention, violating the assumption that familiarity's influence is automatic. In Experiment 2, the similarity of old targets and old nontargets was manipulated to show that source confusions (i.e., misrecollections) violate the assumption that the process of recollection is all-or-none. Source confusions also create an imbalance in the influence of recollection on the inclusion and exclusion tests, violating the consistency assumption. The source-monitoring framework is consistent with the present findings.

Attention↗

PubMed1993

Rate of false source attributions depends on how questions are asked.

Lindsay and Johnson (1989) and Zaragoza and Koshmider (1989) report evidence indicating that "eyewitness" subjects are much less likely to falsely claim to have seen information suggested to them verbally when they receive a source monitoring test than when they receive a recognition test requesting only identification of the seen information. The present study reports additional evidence that source misattributions are affected by the nature of the test. Intraub and Hoffman (1992) recently reported the results of a study in which subjects claimed to have seen pictures corresponding to scenes that had only been described in paragraphs they had read. With this paradigm, we found a similar effect using their test, but source confusions were reduced with a test patterned after the one used by Lindsay and Johnson. We attribute this difference in performance to the different decision criteria evoked by these two tests.

Adult↗