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Biomedical subjects

C S Devi

Publications and source records attributed to C S Devi.

48 records · Page 3Linked to original sources
PubMedDate not supplied

[3H]-thymidine uptake and lipid peroxidation by tumor cells on embelin treatment: an in vitro study.

Using a rapid technique to assess drug-induced cell toxicity, a fibrosarcoma cell line was exposed in vitro to increasing concentrations of embelin, a benzoquinone derivative of Embelia ribes Burm., and simultaneously inoculated with [3H]-thymidine. After regular time intervals, the cells were examined for incorporation of the labelled thymidine in DNA, lipid peroxide and glutathione levels. A dose-dependent decrease in labelled thymidine uptake, lipid peroxide and glutathione levels was observed on embelin administration.

Animals↗
PubMedDate not supplied

Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.

Embelin, a plant-based benzoquinone derivative, has been found to exhibit significant antitumor activity in methylcholanthrene-induced fibrosarcoma in albino rats besides enhancing their survival time. The drug also has an appreciable action on pain and inflammation. The changes in DNA, RNA and protein levels in various organs in the tumor-bearing control and the drug-treated animals were also studied.

Analgesics↗