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Biomedical subjects

C S Bryan

Publications and source records attributed to C S Bryan.

At least 163 records · Page 9Linked to original sources
PubMed1979

Overwhelming opportunistic histoplasmosis.

A patient with chronic granulocytic leukemia developed overwhelming histoplasmosis. During massive fungemia, 59% of peripheral blood neutrophils contained yeast forms. Disseminated intravascular coagulation occurred. Histoplasma capsulatum was isolated not only from the patient's tissues and urine, but also from a serum sample submitted to a reference laboratory for serological testing. The microorganism was demonstrated by specific immunofluorescent staining of peripheral blood films. We suggest that histoplasmosis deserves a definite place on the roster of "opportunistic fungi".

Antineoplastic Agents↗
PubMed1979

Intravenous metronidazole therapy for Bacteroides fragilis meningitis.

A 69-year-old man developed meningitis due to Bacteroides fragilis and Streptococcus MG-intermedius, which progressed during chloramphenicol and nafcillin therapy to the extent that he seemed near death, with frank pus covering the spinal cord at surgery. Treatment with intravenous metronidazole and penicillin G was curative. After multiple trauma, a 20-year-old man developed meningitis due to Escherichia coli and B fragilis. He failed to respond to chloramphenicol alone, but responded to combined treatment with chloramphenicol and metronidazole. The right frontal sinus and epidural space abscesses were drained and a right frontal lobe abscess was excised. Metronidazole may be a uniquely effective agent for treatment of meningitis due to susceptible strains of Bacteroides fragilis.

Adult↗
PubMed1979

Posttraumatic meningitis due to ampicillin-resistant Hemophilus influenzae. Case report.

Two men who sustained skull fractures secondary to blunt head trauma developed meningitis due to Hemophilus influenzae type b. The isolates in both cases were resistant to ampicillin but susceptible to chloramphenicol. Based of this experience, and recent epidemiological trends, it is suggested that chloramphenicol, rather than penicillin G, might be the initial therapy of choice for posttraumatic meningitis when no micro-organisms are recognized on Gram-stained smears of the cerebrospinal fluid.

Adult↗
PubMed1979

Doing good well.

Explore the source record for details and available documents.

Health↗
PubMed1978

Safety of oral vancomycin in functionally anephric patients.

Administration of a vancomycin oral solution, 2 g daily for 16 days, to functionally anephric patients without inflammatory bowel disease resulted in assayable but low (</=0.66 mug/ml) serum levels in two of the five volunteers.

Administration, Oral↗
PubMed1978

Postpartum cytomegalovirus infection. A hazard of multiple transfusions.

A patient whose postpartum course included the defibrination syndrome and Bacteroides septicemia developed recurrent high fever. Cytomegalovirus infection was suspected on the basis of the clinical features and a history of massive blood transfusion, and was confirmed by subsequent observations. Recognition of this disease and its typically benign course averts the need for extensive diagnostic procedures, exploration, and empiric drug therapy trials.

Adult↗
PubMed1978

Endocarditis related to transvenous pacemakers. Syndromes and surgical implications.

Two cases of microbial endocarditis related to transvenous pacemakers illustrate syndromes whose pathogenesis we consider to be distinctive. Acute Pseudomonas aeruginosa endocarditis related to a pacemaker developed in a 75-year-old man, an event which to our knowledge has not been previously described. There was no evidence of generator site infection, and the sequence of events indicated metastatic implantation of bacteria on traumatized endothelium. A 76-year-old women with a 3 year history of local generator site infection and recurrent fever was found to have extensive vegatative Staphylococcus epidermidis endocarditis at cardiotomy. The sequence of events indicated gradual spread of infection locally, related to the contaminated foreign body. Awareness of these separate pathogenetic mechanisms should facilitate recognition and appropriate management. Removal of the entire pacing system and prolonged antibiotic therapy were considered to be essential to cure of infection in both instances.

Aged↗