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Biomedical subjects

C Rozman

Publications and source records attributed to C Rozman.

At least 415 records · Page 23Linked to original sources
PubMed1983

[Cutaneous myelofibrosis].

A case of myelofibrosis with papulonodular cutaneous lesions in a 49 year old man is reported. The histopathological studies showed the presence of the three hematopoietic lines in the skin lesions, which is a uncommon feature.

Hematopoietic Stem Cells↗
PubMed1983

Bone marrow biopsy in chronic lymphocytic leukaemia: a study of 208 cases.

In 208 cases of chronic lymphocytic leukaemia (CLL) in which a bone marrow biopsy has been performed, the correlation between histopathological bone marrow patterns (interstitial, nodular, mixed and diffuse) and both Rai's clinical stages and the recent International Workshop on CLL proposal (A, B, C stages) has been analyzed. In general, a fairly good correlation has been found between the bone marrow patterns and both Rai's and A, B, C systems. As far as the correlation between the bone marrow patterns and the tumoral load (lymphadenopathy, organomegalies, lymphocytosis, anaemia and thrombocytopenia) is concerned, the correlation was also fairly good. Bone marrow pattern is an important prognostic factor in CLL and it is suggested to use a combined clinical and pathological (bone marrow biopsy) staging in CLL.

Aged↗
PubMed1982

Specific cutaneous manifestations of Waldenström's macroglobulinaemia. A report of two cases.

Patients affected by Waldenström's macroglobulinaemia may rarely present specific cutaneous manifestations. The violaceous plaques or tumours infiltrated by lymphoplasmocytoid cells, and the pink, translucent, shiny papules composed of deposits of hyaline monoclonal IgM possess definite clinico-pathological characteristics that may permit the diagnosis before any other data were available. The immunopathological and ultrastructural features of these lesions are described.

Aged↗
PubMed1982

Transient dyserythropoiesis in repopulated human bone marrow following transplantation: an ultrastructural study.

Transmission electron microscopy was used to examine marrow samples from 15 patients with aplastic anaemia or acute leukaemia who had been treated with bone marrow transplantation. There were 11 allogeneic, three syngeneic and one autologous graft. The purpose was to estimate the frequency, type and extent of dyserythropoietic change. Transient dyserythropoietic features were substantiated in all cases. Nuclear changes were present in 12 cases, iron laden mitochondria (sideroachrestic phenomena) in 10 and cytoplasmic contacts and/or connections between red cell precursors in 10. Dyserythropoiesis was most conspicuous in the majority of cases between 14 and 28 d after transplantation but it may persist for over 100 d. No deficit in red cell production was noted and it is proposed that dyserythropoiesis in this circumstance is a physiological rather than a pathological phenomenon.

Anemia, Aplastic↗