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Biomedical subjects

C Rozman

Publications and source records attributed to C Rozman.

At least 307 records · Page 17Linked to original sources
PubMed1987

A multivariate analysis of prognostic factors in chronic myelomonocytic leukaemia according to the FAB criteria.

In an attempt to characterize the prognostic significance of the main initial clinical, haematological and biochemical features of chronic myelomonocytic leukaemia according to the FAB criteria, 29 such patients were analysed by means of univariate and multivariate statistical methods. At the time of the analysis 21 patients had died, with a median survival for the overall series of 8.2 months. The univariate analysis identified three parameters associated with poor prognosis: high monocyte counts, low platelet counts and splenomegaly. When all the initial features were included in a multiple regression model, only high monocyte counts and spleen enlargement retained their unfavourable prognostic influence (P = 0.002 and P = 0.02, respectively). Based on the presence or not of these prognostic factors, two populations of patients with different survival (median survival 5.6 and 16.5 months, respectively, P less than 0.005) could be identified. It seems therefore that monocytic proliferation serves not only as the diagnostic marker for chronic myelomonocytic leukaemia but also as the most important feature in the assessment of the patient's prognosis.

Actuarial Analysis↗
PubMed1987

Hepatic sinusoidal dilatation in Hodgkin's disease.

Examination of needle liver biopsy specimens from 46 patients with Hodgkin's disease revealed sinusoidal dilatation with a predominantly centrolobular and midlobular localisation in 23 cases (50%). It was present in 90% of patients with general symptoms and in only 20% of those without them (p less than 0.001), and it was unrelated to the staging, the existence of hepatic infiltration by the disease and the lymph node histology. The pathogenesis of the sinusoidal ectasia is not known, but it might be a consequence of an alteration of the sinusoidal barrier, since no abnormality of the hepatocytes or of the hepatic venules was detected at light microscopy. Sinusoidal dilatation may be considered as a further systemic manifestation of Hodgkin's disease.

Adolescent↗
PubMed1987

"Spontaneous" complete remissions in chronic lymphocytic leukemia: report of three cases and review of the literature.

"Spontaneous" complete remissions (SCR) are a rare event in chronic lymphocytic leukemia (CLL). In this article, we report three cases of SCR observed in a series of 285 patients followed at a single institution during the last 15 years. SCR was documented by clinical and hematologic data, including bone marrow biopsy, and immune cell markers. A delay of 0.9-1.6 years between "clinical" and "clonal" remission was observed. A review of other cases of SCR in CLL is also performed.

Aged↗
PubMed1987

Bone marrow biopsy in chronic lymphocytic leukemia: a review of its prognostic importance.

In recent years important advances have been made in predicting the survival of patients with chronic lymphocytic leukemia (CLL). Other prognostic factors in addition to clinical staging systems have proved to be of value. Among them, bone marrow biopsy has emerged as a particularly useful prognostic tool. Patients with nondiffuse bone marrow involvement survive longer than those with diffuse involvement. This parameter is useful for subclassifying clinical stages in low- (nondiffuse patterns) and high- (diffuse patterns) risk groups. The use of a combined clinicopathological staging system for CLL seems advisable.

Biopsy↗
PubMed1987

Hybridoma process: ultrastructural cytology of different stages.

In order to define the ultrastructure of the hybridoma cell and to learn more about the plasmocytic differentiation process, a scanning (SEM) and transmission (TEM) electron microscopy study of several cell types involved in the production of monoclonal antibodies was performed. Cells of the three different stages in hybridoma process were studied. These cells included NS/1 murine myeloma cells, 40-3A4 in vitro cultured hybridoma and 33-1D2 ascitic tumor hybridoma cells. A stereological analysis of the Sv parameter (surface of RER per volume unit of cytoplasm) was performed in the murine myeloma line, the in vitro cultured hybridoma and the ascitic tumor hybridoma. In order to comparatively evaluate the plasmocytic differentiation of these cells the same methodology was applied to splenic lymphocytes from immunized mouse and to mature human myelomatous plasma cells. As expected, during the hybridoma process, a progressive increase in the amount of RER was detected. This was in contrast with the surface characteristics of the cells which become progressively smooth when the hybridoma was cloned, either in vitro or in vivo. From these results it can be inferred that the amount of RER is a more reliable parameter than surface blebs as a morphological element indicative of plasmocytic differentiation. On the other hand, numerous viral particles were present not only in murine myeloma line but also in hybridoma clones secreting monoclonal antibodies.

Animals↗
PubMed1987

Lymphocyte doubling time in chronic lymphocytic leukemia: an update of its prognostic significance.

Clinical staging systems represent an important advance in predicting the course speed of CLL. Clinical staging systems do not, however, offer information with respect to the speed of evolution of the disease. Lymphocyte doubling time (LDT) is a simple parameter that is useful in arriving at a valid prognosis in CLL. Whereas a high LDT (greater than 12 months) identifies a population with a very good prognosis (median survival, not reached), a low LDT (less than or equal to 12 months) is associated with a poorer survival (median survival, 58 months). In addition, a short LDT predicts rapid disease progression in patients in the early clinical stages.

Female↗
PubMed1986

Cytogenetic studies in blast crisis of Ph-positive chronic granulocytic leukemia: results and prognostic evaluation in 52 patients.

Bone marrow cytogenetic (G-banding) studies were carried out in 52 patients with Ph-positive chronic granulocytic leukemia (CGL) at the time of diagnosis of blast crisis. In all cases, the Ph chromosome was due to the standard (9;22) translocation. Eighteen patients displayed the 46,Ph cell line unchanged, whereas additional chromosome abnormalities were observed in the remaining 34 patients (65.4%). Among the latter, numerical karyotypic changes were found in 31 patients and structural changes in 8 patients. Five patients displayed numerical and structural changes simultaneously. The most common chromosome numerical changes were an extra #8 (14 cases) and additional Ph chromosomes (11 patients); an i(17q) was the most frequently observed structural change (3 cases). These three aberrations were often combined; at least one of them was present in 21 patients, constituting 62% of the cases with new cytogenetic abnormalities at blast crisis. When comparing the clinical and hematologic characteristics, as well as the survival, of patients retaining the unchanged 46,Ph cell line and patients showing additional chromosome changes, no differences were found between the two groups of patients. However, a minority displaying a hypodiploid modal chromosome number survived significantly longer than the remaining patients.

Adult↗
PubMed1986

Decreased bone marrow iron in chronic granulocytic leukaemia: a consistent finding not reflecting iron deficiency.

The iron status of 50 patients with Ph'-positive chronic granulocytic leukaemia (CGL) was evaluated at diagnosis by means of bone marrow and blood studies. A decreased or absent iron in semiquantitative estimation on bone marrow smears was observed in 92% of patients, and 88% had a low sideroblast score. In contrast, normal Hb and serum iron concentrations were found in the majority of cases, and only two out of the 50 patients displayed a decreased serum ferritin. To ascertain whether the bone marrow pattern of iron depletion could be due to an expansion of the red cell mass, the latter parameter was measured by isotopic methods in a subgroup of 11 patients. Normal or slightly increased values were obtained in all cases. We conclude that absent or decreased marrow iron is a common feature in the chronic phase of CGL, that generally does not reflect true iron deficiency. Since such a finding is also usual in polycythaemia vera and idiopathic myelofibrosis, it should be included among the features shared by the chronic myeloproliferative disorders.

Anemia, Hypochromic↗
PubMed1986

Treatment of alkylating resistant multiple myeloma with vincristine, BCNU, doxorubicin and prednisone (VBAP).

A total of 33 evaluable patients with multiple myeloma refractory to alkylating agents were treated with the regimen vincristine, BCNU, doxorubicin, and prednisone (VBAP) at 3-week intervals in a single institution for a 5-yr period. An overall response rate of 21.2% was achieved (9% objective plus 12.2% improvement). Treatment was well tolerated. The overall median survival was 7.5 months. However, responding patients attained a median survival of 27.4 months vs. 5 months for similarly treated nonresponding subjects (P = 0.051). These results indicate that VBAP is an effective treatment for a proportion of patients with advanced refractory multiple myeloma.

Adult↗