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C Roussel

Publications and source records attributed to C Roussel.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

An approach to discriminating 25 commercial chiral stationary phases from structural data sets extracted from a molecular database.

We have developed a comprehensive molecular database (CHIRBASE) which contains today the results of 35,000 chiral separations by liquid chromatography, 2-D Structural searches have been used to determine at which frequency a molecular characteristic is present in a population of compounds separated on a given chiral stationary phase. To simplify the screening, we have searched 15 empirical molecular descriptors in a selection of 5000 solutes separated on 25 stationary phases. A correspondence analysis was then performed on this set of data (graphical representation of CSPs and descriptors). We then attempt to classify the behaviour of chromatographic systems with the help of hierarchical ascending classification.

Chromatography, High Pressure Liquid↗
PubMedDate not supplied

Influence of the concentration of motile sperm inseminated on the ovum penetration assay results: toward a standardized method.

The influence of the concentration of motile sperm inseminated on the zona-free hamster egg penetration rate has been studied. In 3 fertile men, the higher the concentration of motile sperm inseminated, the higher the ovum penetration rate. This correlation emphasizes the usefulness of standardizing the technical conditions under which the ovum penetration assay is performed. It is also suggested to refer to a standard curve for results analysis. In the 22 patients studied, the outcome of the heterologous ovum assay was in most cases related to the initial sperm parameters. However, some disagreement was also observed. In the absence of a correlation between the initial sperm parameters and the ovum penetration rates, further investigation is needed in order to either more precisely determine the aetiology of unexplained couple infertility, or, in case of intrauterine insemination or in vitro fertilization, to better understand the conditions under which spermatozoa are capacitated in vitro.

Animals↗