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Biomedical subjects

C Rosendorff

Publications and source records attributed to C Rosendorff.

At least 109 records · Page 6Linked to original sources
PubMed1970

Acute effects of a monoamine oxidase inhibitor, tranylcypromine, on thermoregulation in the conscious rabbit.

1. The effect of a single injection of the monoamine oxidase inhibitor, tranylcypromine, administered intravenously (20 mg/kg) or into the lateral cerebral ventricle (5-10 mg), on hypothalamic and rectal temperature, has been investigated.2. Intravenous tranylcypromine causes a significant rise in body temperature, which is due, at least in part, to cutaneous vasoconstriction; this vasoconstriction is augmented by sympathectomy. It is concluded that this vasoconstrictor effect is not mediated via the central nervous system.3. Intraventricular tranylcypromine caused a transient but significant fall in core temperature. This is interpreted as being compatible with selective augmentation of hypothalamic levels of 5-hydroxytryptamine.

Animals↗
PubMed1970

The effects of salicylate on temperature regulation in the rabbit.

1. A stable pyrexia has been produced in rabbits by intravenous injection of leucocyte pyrogen followed by a continuous infusion.2. Intravenous sodium salicylate, given 4 hr after the start of pyrogen infusion, induced rapid and progressive defervescence. The rate of fall of temperature was dose dependent.3. Intravenous injection of sodium salicylate had no effect on the temperature of afebrile rabbits.4. The intraventricular injection of small doses of sodium salicylate, given 4 hr after the start of a pyrogen infusion, caused a rapid, dose-dependent defervescence, but had no significant effect on the temperature of afebrile rabbits.5. Salicylates exert at least part of their antipyretic activity through an action on the central nervous system.

Animals↗
PubMed1970

Observations on the mechanism of salicylate-induced antipyresis.

1. Fever has been produced in conscious rabbits, first, by injection of leucocyte pyrogen into the lateral cerebral ventricle and, second, by local cooling of the hypothalamus.2. Both intravenous and intraventricular salicylate produce antipyresis during an established fever due to intraventricular leucocyte pyrogen. This is incompatible with the hypothesis that salicylate acts by interfering with the passage of leucocyte pyrogen from the circulation into the hypothalamus.3. Intravenous sodium salicylate has no effect on the fever due to local cooling of the hypothalamus. This suggests that salicylates do not act on central or peripheral efferent pathways involved in thermoregulation.

Animals↗
PubMed1967

Central temperature regulation in the conscious rabbit after monoamine oxidase inhibition.

1. Measured thermal loads were applied to conscious rabbits by intravenous infusions of hot or cold saline. The responses of the central temperature regulating mechanism were assessed by measuring hypothalamic temperature change. The relationship between thermal load and temperature response was established in normal animals.2. Intramuscular injection of tranylcypromine (20 mg/kg. day for 6-8 days) had no effect upon resting temperature or the temperature response to thermal loads, though the diencephalic concentrations of noradrenaline and 5-hydroxytryptamine (5-HT) were increased.3. Either hypothalamic monoamines are not concerned in the regulation of normal temperature or there is a monoamine ;pool' in the hypothalamus which is concerned with temperature regulation but which is unaffected by monoamine oxidase inhibition.

Animals↗