Biomedical subjects
Publications and source records attributed to C Robertson.
A family with dominantly inherited short stature, short broad hands and feet, normal facial appearance and normal intelligence is described. Radiographs demonstrated features of brachydactyly type E. A differential diagnosis of brachydactyly is given.
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Averaged auditory brainstem responses (ABR) elicited by unfiltered clicks were recorded from 14 asphyxiated neonates with clinical evidence of CNS suppression at 3-17 days of age, and from a group of healthy neonates matched in gestation period and weight. Statistically significant differences were found between the two groups in several ABR parameters and characteristics. In general, longer ABR component latencies and interwave intervals were the rule in the asphyxiated group. Short-term follow-up of the asphyxiated infants suggested that the ABR is sensitive to recovery trends from hypoxic encephalopathy. The results of a 6-month follow-up are also summarized. The results are discussed with regard to the histopathological and experimental information available from current literature.
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A 23-year-old woman ingested 2g. amylobarbitone, 10.4g. aminophylline and 2g. ephedrine. She was deeply unconscious, hypothermic, and went on to have supraventricular and ventricular dysrhythmias, convulsions and haematemesis. During the last convulsion she aspirated vomitus and died. The peak plasma concentration of amylobarbitone was 19mg. per l. and those of ephedrine and theophylline were 13 times higher than accepted therapeutic levels. During the course of the poisoning marked hypokalaemia (1.8mmol./l.) and hyperinsulinaemia (greater than 240mU./l.) were found in conjunction with mild hyperglycaemia (9.6mmol./l.) and elevation of free fatty acid levels (1860mumol./l.). The mechanism of these changes is discussed.
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Partial trisomy (interchromosomal duplication) of the short arm of chromosome No. 12 was observed in an infant girl with psychomotor retardation, prominent forehead, ptosis of the right eyelid, esotropia/exotropia, flat nose, hypotonia and other anomalies. A comparison of her features with those in five reported cases with a similar chromosomal imbalance shows certain features common to all, but the material is too limited for definitive characterization of a trisomy 12p syndrome.
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The authors present the case of an infant with laryngeal stridor, apneic spells, and an open lumbar myelomeningocele; granulomatous vernix caseosa meningitis was found at autopsy. The suggest that chemical meningitis which also involved the cranial nerves might be held partly responsible for the laryngeal stridor.
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There has been an increasing interest in patient satisfaction assessment across nations recently. This paper reports on a cross-cultural comparison of the comprehensive assessment of satisfaction with care (CASC) response scales. We investigated what proportion of patients wanted care improvement for the same level of satisfaction across samples from oncology settings in France, Italy, Poland and Sweden, and whether age, gender, education level and type of items affected the relationships found. The CASC addresses patient's satisfaction with the care received in oncology hospitals. Patients are invited to rate aspects of care and to mention for each of these aspects, whether they would want improvement.One hundred and forty, 395, 186 and 133 consecutive patients were approached in oncology settings from France, Italy, Poland and Sweden, respectively. Across country settings, an increasing percentage of patients wanted care improvement for decreasing levels of satisfaction. However, in France a higher percentage of patients wanted care improvement for high-satisfaction ratings whereas in Poland a lower percentage of patients wanted care improvement for low-satisfaction ratings. Age and education level had a similar effect across countries. Confronting levels of satisfaction with desire for care improvement appeared useful in comprehending the meaning of response choice labels for the CASC across oncology settings from different linguistic and cultural background. Linguistic or socio-cultural differences were suggested for explaining discrepancies between countries.
Problems with the interpretation of age-period-cohort models are discussed. If individual records are available for cancer incidence in Scotland, then a solution is obtainable. An example using incidence data for cancers of the lung and larynx in Scotland is presented to illustrate the models.