Search PubMed⌕ Search

Biomedical subjects

C Richart

Publications and source records attributed to C Richart.

At least 163 records · Page 9Linked to original sources
PubMed1981

[Islet cell antibodies in diabetic patients with other autoimmune diseases (author's transl)].

The presence of antibodies directed against pancreatic islet cells was investigated in 18 insulin pendent diabetic patients with autoimmune disease (Group 1), in 8 insulin-independent diabetic patients with autoimmune disease (Group 2), in 42 non-diabetic patients with thyroid antibodies (Group 3), in 18 patients with antibodies against gastric parietal cells (Group 4) and in 100 healthy subjects (controls). Islet cell antibodies were found in 46% of group 1 patients and in only 1 patient of group 3 and 1 control. This would suggest the existence of a special form of autoimmune insulin-dependent diabetes characterized by a high incidence of islet cell antibodies and associated with other autoimmune diseases.

Autoantibodies↗
PubMed1980

[Islet cell antibodies in diabetes mellitus (author's transl)].

The existence of islet cell antibodies (ICA) strongly supports an autoimmune pathogenetic mechanism for insulin-dependent diabetes. ICA have been determined in a group of 205 diabetics with the following results: ICA were present in 76 percent of insulin-dependent diabetics with symptomatology lasting less than 8 weeks, in 20 percent of the remaining insulin-dependent diabetics, in 5 percent of non-insulin-dependent diabetics, and in 1 percent of the control subjects. Thyroid antimicrosome antibodies and antiparietal-cell antibodies were determined too, but no significant relationship was demonstrated in insulin-dependent diabetics with positive ICA. Under a clinical point of view the comparison between diabetics with and without ICA has been of no value for determining differential characteristics in relation to metabolic seriousness, epidemiological data, and complication rate.

Adolescent↗
PubMed1980

[New contributions to the etiology of insulin-dependent diabetes (author's transl)].

The present studies on the possible factors that can be implicated in the etiopathogenesis of diabetes are reviewed. The association between insulin-dependent diabetes and certain specifications of the HLA system are commented on, as well as the experimental studies and the clinical observations which indicate the possible relationship between this disease and some viruses. The role played by autoimmunity is thoroughly discussed, specially the significance of anti-pancreatic islet antibodies. Finally, new pathogenic theories and classifications of the disease are proposed.

Autoantibodies↗
PubMed1979

[The usefulness of the quantitative evaluation of the plasma levels of the carcinoembryonic antigen (CEA) in patients with respiratory neoplasms (author's transl)].

Plasma concentration of the carcinoembryonic antigen (CEA) was determined by radioimmunoassay in 80 patients affected with different neoplasms of the respiratory system, among which the most predominant was bronchial carcinoma. For this type of tumor the results showed a percentage of positivity of 69 percent, with a greater value in the disseminated neoplasias (81 percent) in comparison with those which were localized (48 percent). The concentrations of the antigen were greater in the metastatic tumors; in 55 percent of the cases levels above 40 ng/ml were observed. On the other hand this figure was reached only by 4 percent of the localized tumors. Values of the antigen higher than 40 ng/ml should lead to the suspicion of the existence of neoplastic widespread. Among the rest of the series the negativity noticed in all the cases of pleural mesothelioma stands out, and indicates that this type of tumors does not produce CEA.

Adenocarcinoma, Bronchiolo-Alveolar↗