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C Richardson

Publications and source records attributed to C Richardson.

207 records · Page 12Linked to original sources
PubMedDate not supplied

Drug-like annotation and duplicate analysis of a 23-supplier chemical database totalling 2.7 million compounds.

We have implemented five drug-like filters, based on 1D and 2D molecular descriptors, and applied them to characterize the drug-like properties of commercially available chemical compounds. In addition to previously published filters (Lipinski and Veber), we implemented a filter for medicinal chemistry tractability based on lists of chemical features drawn up by a panel of medicinal chemists. A filter based on the modeling of aqueous solubility (>1 microM) was derived in-house, as well as another based on the modeling of Caco-2 passive membrane permeability (>10 nm/s). A library of 2.7 million compounds was collated from the 23 compound suppliers and analyzed with these filters, highlighting a tendency toward highly lipophilic compounds. The library contains 1.6 M unique structures, of which 37% (607,223) passed all five drug-like filters. None of the 23 suppliers provides all the members of the drug-like subset, emphasizing the benefit of considering compounds from various compound suppliers as a source of diversity for drug discovery.

Journal Article↗
PubMedDate not supplied

Building a case for promotion of clinical faculty.

A newly created and approved clinical faculty track was without a well-defined path to promotion. The authors describe how the school of nursing clinical track faculty integrated the 4-part model of scholarship defined by Boyer and Rice into the traditional promotion triad of research, teaching, and service. The authors' challenge was defining promotion guidelines to achieve respect, reward, and promotion.

Career Mobility↗
PubMedDate not supplied

New therapies for rheumatoid arthritis.

There are two major thrusts in the development of effective treatments in RA: the use and development of entirely new drugs; and the more effective usage of the currently available drugs. This represents a comprehensive review of the pharmacological agents that have been recently developed or will be available in the near future.

Adjuvants, Immunologic↗