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Biomedical subjects

C Ricci

Publications and source records attributed to C Ricci.

At least 271 records · Page 15Linked to original sources
PubMed1981

[Fasting glycosylated hemoglobin A1c and behavior of blood sugar and blood insulin after oral glucose tolerance test in subjects with a family history of diabetes].

In a group of subjects with a known family history of diabetes (subjects with high risk of diabetes) and in two control groups, one of normal subjects and the other of poorly controlled insulin-dependent diabetic patients, all with normal blood levels of cholesterol and triglyceride, the fasting HbA1c concentration and the glycemic and insulin response to OGTT (1 g/kg of body weight) were studied. A prompt increase in serum insulin was observed both in normals and in subjects with a known family history of diabetes (poor in diabetics, of course), but insulin peak was significantly higher in the second ones. As in diabetes patients as in subjects with a known family history of diabetes, the HbA1c levels were significantly higher than in normal subjects, but significantly less high in subjects with a known family history of diabetes than in diabetics. These data might suggest that the prediabetic states generally joint with hyperinsulinemia and the HbA1c determination could contribute to the selection of those prediabetic states.

Adult↗
PubMed1981

[The response of pancreatic alpha and beta cells to oral glucose stimulation in subjects with risk of diabetes].

Oral glucose tolerance tests (g 1/kg body weight were performed in 14 high diabetic risk subjects (mean age: 39,5 years), 9 insulin-dependent diabetic patients (mean age: 37,8 years) and 14 normal subjects (mean age: 31,5 years). Glucose, IRI and IRG were determined at various intervals. In the high diabetic risk subjects: 1) the OGTT was normal; 2) the insulin response to carbohydrate ingestion was significantly higher than in normals and, of course, in diabetics; 3) the fasting glucagon levels showed no significant differences from the normals; 4) significant suppression of fasting glucagon concentration was observed in normals after oral glucose, but not in high diabetic risk subjects and in diabetic patients. On the basis of our findings it might be suggested, therefore, that in the subjects, who are genetically pre disposed to developing diabetes mellitus, insulin does not suppress pancreatic glucagon secretion or owing to a functional disorder among alpha- beta- and delta-cells, somatostatin secretion is deficient or slow with following hyperinsulinemia and hyperglucagonemia.

Adult↗
PubMed1980

PHA and ConA lymphocyte response in normal, hyperplastic and neoplastic human thymus: morphologic and functional correlations.

In the present work the in vitro response to PHA and ConA was determined for thymus lymphocytes from normal, hyperplastic, and neoplastic conditions as well as for peripheral blood lymphocytes from normal control donors. Our investigation has revealed these results: (1) lymphocytes from normal thymus are less responsive to both mitogens than lymphocytes from peripheral blood and abnormal thymus. (2) Lymphocytes from thymic benign lymphoid hyperplasia show an increased response only to PHA regardless of the extent of hyperplasia. (3) Lymphocytes from thymic neoplasia display an increased response to both mitogens regardless of the histologic pattern of the tumor studied. (4) Thymic lymphocytes from patients with myasthenia gravis have a mitogenic response higher than that from thymic lymphocytes from nonmyasthenic subjects. (5) In patients with myasthenia gravis, lymphocytes from neoplastic thymus show a response to PHA higher than that observed for lymphocytes from hyperplastic thymus. It seems clear that two conditions maximally enhance mitogenic response of thymus lymphocytes: thymomas and myasthenia.

Adolescent↗
PubMed1980

[Method for testing niacin bound activities in man].

In order to value the availability of niacin in man, it has been more suitable to test erythrocyte nicotinate-phosphoribosyltransferase and nicotinamide-phosphoribosyltransferase activities. These enzymes catalyze the production of Des-NMN and NMN from free bases. The radioactive compounds, produced from [14C] NAc and [14C] NAm, are isolated by a gel chromatography and counted in liquid scintillation. It has been observed that nicotinamide-phoshoribosyltransferase is scarcely active in human erythrocytes, while the nicotinate-phosphoribosyltransferase gives a good indication of niacin availability.

Carbon Radioisotopes↗
PubMed1980

[Changes in rat liver enzymatic activity induced by CT 1341 (althesin) administration].

Six enzyme activities with different intracellular localization were selected for a study of the metabolic effects caused by CT 1341 (Althesin). Glucose-6-phosphato-phosphatasic, ATP-asic and aryl-4-hydroxylasic (hydroxylasic aniline) activities are in fact localised in the microsomial fraction whereas glucose-6-phosphato-dehydrogenasic, 6-phosphogluconic dehydrogenasic and UDP-glucoso-dehydrogenasic activities are to be found in the soluble fraction. The Althesin doses used varied between 0.75 and 6 mg/kg body weight, but only the latter dose is capable of triggering significant variations. With the exception of glucose-6-phosphato-phosphatase, which falls markedly, and ATPase which behaves discontinuously, the other enzyme activities increase to reach their maximum between the 15th and 30th minute after treatment. The diminution in glucose-6-phosphato-phosphatasic activity is attributable to a drug-induced change in the microsomial membranes. The increase in other activities, on the other hand, is connected with drug metabolisation. On a par with other steroid compounds, CT 1341 to be eliminated, must go through a hydroxylation reaction requiring higher production of NADPH. Its elimination also requires a higher concentration of UDP-glucuronic. The data obtained with separate injection of the active principles making up the drug did not give results in agreement with those obtained with the commercial product and, for the present, no final conclusions can be drawn.

Adenosine Triphosphatases↗
PubMed1979

[Obstructive cardiomyopathy with idiopathic hypertrophic subaortic stenosis in the pediatric age].

The clinical and haemodynamic features of obstructive cardiomyopathy with hypertrophic subaortic stenosis in a 12-yr-old boy are examined. A cardiac souffle had been present for 10 yr and precordial pain, cardiopalmus and effort dyspnoea for 5-6 yr. Familial association, ischaemic and pseudonecrotic ECG changes, and signs of left ventricle hypertrophy were noted. Left catheterisation and ventriculography showed obstructive hypertrophy of the muscle, two chambers with filling at 160/10 and ejection at 120/10, and slight regurgitation into the left trium. Treatment with 0.2-0.5 mg/kg/day propranolol.

Aortic Stenosis, Subvalvular↗
PubMed1979

Present tendencies in the surgical treatment of pectus excavatum.

Among the malformations of the chest wall, pectus excavatum is undoubtedly the most frequent. It may appear in various forms and may show varying degrees of severity. Surgical correction by operation is mostly sought by the patients for aesthetic reasons. After careful review of the methods proposed by various writers for the correction of this malformation, the present writers emphasize the advantages and disadvantages of these techniques, especially in relation to the methods of stabilising the reduction. Finally, they report on their own case material and present some significant examples.

Adolescent↗
PubMed1978

[Sea-blue histiocytosis. Clinical and immunological study of a familial case].

This case (a young man) presented a clinical picture of a hard periorbital edema, hepatosplenomegaly and a mild bilateral pulmonary fibrosis. The histopatological pattern of our case (as well as his sister affected with the same syndrome) was characterized by the presence of macrophages full of blue staining granules and bone marrow macrophagic infiltrations. In the pulmonary function tests the volumes and compliance test and diffusing capacity were normal. The enzymatic deficit of the macrophage leads to the increase storage of phosphoglicerides and phosphosphingolipids responsibles for the blue staining with Wright-Giemsa stain. Our case fit into the specific pathology of the macrophage cell in accordance with the more recent views of the autonomy of the MPS (Mononuclear Phagocytic System). The known relationship between macrophages and T and B lymphocites have prompted us to study the cellular and humoral immunological behaviour of our case. We have observed an increased IgM immunoglobulins and an increase of IgM surface membrane receptors. Our results will be illustrated and compared with the until known 70 publicated cases.

Adult↗