Search PubMed⌕ Search

Biomedical subjects

C Rampulla

Publications and source records attributed to C Rampulla.

At least 91 records · Page 5Linked to original sources
PubMed1976

[The heart in myasthenia gravis. Electrocardiographic, cardiodynamic and kinetocardiographic aspects in 18 cases].

Eighteen patients with myasthenia gravis, second-stage (A or B) according to Ossermann and Genkins, and of young age, were examined as outpatients from the cardiological point of view. Clinical and radiological examination of the heart and large vessels revealed no pathological features. Electrocardiographic abnormalities (including one case of ventricular preexcitation syndrome and one of subepicardial ischemia) were detected in three patients (16,6%). Among the various left ventricular systolic time intervals, only the deformation time was somewhat off normal limits in some cases, but the difference was not statistically significant. In over one-third of the cases, conversely, the kinetocardiogram revealed paradoxical systolic outward movements, indicative of myocardial dyskinesis or dissinergy. The essential normality of systolic time intervals in the presence of manifest abnormalities of the kinetocardiographic curve may be explained by the smallness of hypokinetic or dyskinetic areas, whereby the ejection fraction was not reduced. In general, the ECG and kinetocardiographic tracings showed no tendency to change under the effect of orally administered pyridostigmine.

Adolescent↗
PubMed1976

Regional lung perfusion and pulmonary artery pressure in chronic obstructive lung disease.

In 22 chronic bronchitics with or without emphysema, the authors measured regional pulmonary perfusion in the supine position and calculated the ratios of radio-active tracer (131I-MAA) concentrations in the lung apices and bases (U/L ratio). This ratio was found to be normal in the right lung and tendentially high (though not to a statistically significant degree) in the left lung, this being probably due to the presence of an enlarged heart (13 patients showed evidence of right ventricle hypertrophy and/or overload). The correlation between the U/L ratio and functional impairment of respiration expressed spirometrically failed to reach statistical significance and the same was true of the correlation between the U/L ratio and mean pulmonary arterial pressure at rest.

Adult↗
PubMed1976

Correlations between lung-transfer factor, ventilation, and cardiac output during exercise.

In nine healthy and young subject of either sex, undergoing three or four rounds of muscular exercise of increasing severity on a bicycle ergometer, the authors investigated the behavior of the lung transfer factor (Dlco), pulmonary ventilation (V), alveolar ventilation (Va), and cardiac output (Q). In all instances they found a positive linear correlation between DLCO and oxygen consumption (VO2), at least up to 70% of maximum oxygen consumption (Vo2max) (r=0.935;p less than 0.001). Dlco was found to increase linearly as a function of increasing V (R=0.898;P LESS THAN 0.001) AND EVEN MORE SO OF INCREASING Va (r=0.919; p less than 0.001). Also the relationship between Dlco and Q appeared linear in all subjects (r=0.926; p less than 0.001). On the other hand, individual Dlco values showed considerable scatter at equal Vo2, V, Va, and Q values. Among the factors responsible for the increase of Dlco during muscular exercise, in addition to increased ventilation and cardiac output, the authors suggest the possible role of the greater desaturation of mixed venous blood and variations of hemoglobin affinity for CO.

Adolescent↗
PubMed1976

[Early changes of respiratory function in mitral valve stenosis].

In order to detect early changes of respiratory function in patients affects by pure mitral valve stenosis, the authors selected 12 patients-non smokers, without symptoms of respiratory disease, of I and II NYHA class. In all subjects right and left cardiac catheterization and conventional spirometric measurements were performed. Then maximal mid-expiratory flow (MMEF), maximal expiratory flow at 50% of vital capacity (MEF 50%), maximal expiratory flow at 25% of vital capacity (MEF 25%), closing volume (CV) and closing capacity (CC) were determined, to find a small airways (bronchi of caliber inferior to 2 mm) disease. Whereas conventional spirometric measurements showed normal values, the small airways disease was proved by MEF 50% and MEF 25% measurements. The small airways obstruction observed by the authors may be due to: a) dilatation of pulmonary vessels because of venous congestion resulting in the compression of adjacent small airways; b) partial bronchiolar obstruction because of congestion of submucous venous plexus; c) interstitial oedema due to increase of extravascular pulmonary water because of pulmonary venous congestion.

Adult↗
PubMed1975

Can pulmonary artery pressure be predicted without right heart catheterization in chronic obstructive lung disease?

We have investigated the dependance of observed pulmonary artery mean pressure (PAP) on body surface, age, PaO2, pH, PaCO2, hematocrit, and spirometric data (VC, FEV1/VC, RV/TLC) in 70 patients with chronic obstructive lung disease (COLD). After elimination of all variables that failed to correlate with PAP, multifactorial analysis showed that only two of nine independent variables, namely PaO2 and body surface, correlated significantly with PAP. According to our calculations, 28.9% of total PAP is predictable by PaO2, 1.5% by H+ concentration, 2.8% by RV/TLC, and 2.5% by body surface. Fully 64.2% of total variability was not accounted for by our regression analysis; thus the error of predicted PAP was so great (+/- 17 mm Hg for P = 0.05) as to invalidate the method. We also recalculated our subjects' PAP values by applying Enson's and Grassi's equations to our own lung function and biochemical data, and compared the predicted PAP values thus obtained with those measured directly in our subjects. Both equations proved imprecise and/or inaccurate in the individual case. From this we conclude that whereas available equations may be suitable for predicting the mean PAP value of a large population sample, the same equations cannot give a reliable prediction in individual cases.

Adult↗
PubMed1975

[The ventilation-perfusion ratio, with special reference to muscular exercise].

The values of VA/Q obtained at rest in 12 normal subjects undergoing cardiac catheterization in a supine position were between 0.63 and 1.695, with a mean of 1.142 +/- 0.295. The VA/Q values obtained in another 10 healthy subjects tested in a sitting position with a rebreathing method for calculating Q. were somewhat less scattered (between 0.77 and 1.50), and also lower (mean 0.975 +/- 0.210). A highly significant correlation was demonstrated during muscular exercise on the bicycle ergometer (sitting position), both between oxygen consumption and alveolar ventilation and between oxygen consumption and cardiac output. However, since at various submaximal work loads cardiac output increased much less than alveolar ventilation, the overall VA/Q ratio showed a progressive increment with increasing oxygen consumption.

Adolescent↗
PubMed1975

Heart volume determination with phase synchronization in normal subjects and postinfarct patients.

The authors investigated the influence of the systole-and-dyastole cycle upon the cardiac volume measured radiologically with ECG phase synchronization in prone subjects. Measurements were made in 30 healthy subjects and 27 patients with a history of myocardial infarction, all of them ambulatory. As expected, the mean cardiac volume relative to body surface was greater in postinfarct patients than in normal subjects to a high degree of statistical significance. Conversely, the differences between end-systolic and end-diastolic cardiac volumes fell short of statistical significance both in healthy subjects and in postinfarct patients. Accordingly, radiological measurements of cardiac volume without phase synchronization seem justified in the functional evaluation of postinfarct patients.

Adult↗