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Biomedical subjects

C R Stiller

Publications and source records attributed to C R Stiller.

At least 109 records · Page 6Linked to original sources
PubMed1981

Immunological and pharmacological monitoring in the clinical use of cyclosporin A.

Immunological reactivity to donor antigens and serum concentrations of cyclosporin A were monitored in six patients after renal transplantation. At concentrations of 0.1--1.0 microgram/ml cyclosporin A prevented both donor-specific immune reactivity and clinical rejection during the early post-transplant course. Measurement of cyclosporin A levels and immunological indices allowed individual adjustment of the dosage so as to give excellent early graft function with few adverse effects.

Cyclosporins↗
PubMed1981

Percutaneous transluminal dilatation of transplant renal artery stenosis.

Percutaneous transluminal angioplasty has been applied to the treatment of transplant renal artery stenosis in 3 patients, 2 with severe hypertension resistant to medical therapy, and one with graft dysfunction related to the presence of the stenosis in the early post-transplant period. The clinical courses of the patients before and after angioplasty are illustrated and the usefulness of the technique in this difficult situation stressed.

Adult↗
PubMed1979

Inhibition of lymphocyte responses by gold: modulation by time of drug addition and antigen dose.

Gold sodium thiomalate added to peripheral blood mononuclear (PBM) cell cultures inhibits the mixed leukocyte reaction (MLR), and cell-mediated cytotoxicity (CMC). The addition of GST to MLR was inhibitory only if the compound was added at the beginning of culture; late addition of GST did not inhibit MLR, or CMC. In a different set of experiments the number of stimulating cells added to MLR was varied. The inhibitory effects of GST decreased markedly as the number of stimulating cells added to culture was increased. The effects of gold in vivo may be modulated by a number of immunologically competent cells that are already antigenically stimulated, as well as by the amount of available stimulating antigen.

Antigens↗
PubMed1979

Inhibitory effects of gold and other drugs on mononuclear cell responses: a comparison.

The effects of gold sodium thiomalate (GST) were compared with those of acetylsalicylic acid (ASA), D-penicillamine (PEN), and methlyprednisolone succinate (MP) on the mixed leukocyte reaction (MLR), and on cell-mediated cytotoxicity (CMC) using mononuclear cells from normal human volunteers. GST and MP inhibited MLR in concentrations readily achieved in the serum, or tissues of patients. ASA showed only a modest effect on MLR, in high concentrations. All drugs inhibited CMC; PEN inhibited CMC at doses of 100 mcg/ml which were no inhibitory in MLR. ASA inhibited CMC at relatively low concentrations. The effects of some of the drugs on MLR and CMC were not consistent. This may be due to the preferential action of the drugs on various immunologically competent cells.

Aspirin↗
PubMed1979

Monitoring of rejection.

Rejection in non-identical pairs is both antibody- and cell-mediated. Measurements of CDC and LMC specific for the donor can be useful clinical tools in confirming rejection, detecting periods of likely rejection, and helping to predict responses to therapy. In particular, the LMC assay appears to have excellent temporal correlations with graft status. Rejection in the HLA-identical sibling transplant is directed against a non-MHC antigen, is cell-mediated, and can be typed for using CTL.

Antibodies↗
PubMed1978

Histocompatibility antigens as markers of abnormal iron metabolism in idiopathic hemochromatosis.

To determine the frequency of HLA histocompatibility antigens in persons with idiopathic hemochromatosis and their usefulness as genetic markers of the disease, HLA typing for the A, B and C loci was carried out. HLA-A3 was found in 61% of 18 unrelated individuals with idiopathic hemochromatosis compared with 25% of 253 randomly chosen control subjects (P less than 0.001), and HLA-B7 was found in 50% and 22% respectively (P less than 0.025). Eighty-six members of seven families with idiopathic hemochromatosis were screened for abnormalities in iron metabolism with tests for serum iron concentration, transferrin saturation, serum ferritin concentration and iron content of the hepatocytes. Of the 14 persons selected for liver biopsy because of abnormalities detected by these tests, 8 had increased amounts of stainable iron in the hepatocytes. Body iron overload was subsequently demonstrated in six of the seven, who had undergone repeated phlebotomy. In sibships having one member with hemochromatosis, only 1 of 22 members had two haplotypes in common with the proband, whereas in sibships having more than 1 member with the disease 4 of 5 affected members had two haplotypes in common. HLA typing in families with hemochromatosis may provide a means of identifying persons at risk of acquiring the disease.

Epitopes↗
PubMed1978

Beneficial effect of operation-day blood-transfusions on human renal-allograft survival.

In 56 patients 1-year renal-graft survival was significantly better (71% vs 40%) in those who had received blood before operation, confirming previous observations. In addition, transfusion on the day of operation proved to have been beneficial, both in those previously transfused (82% vs 64%) and in those never previously transfused (71% vs 28%). Irrespective of pretransplant transfusion, 1-year graft survival was significantly better (79% vs 44%) in those transfused on the day of operation.

Blood Transfusion↗