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Biomedical subjects

C R Spillert

Publications and source records attributed to C R Spillert.

76 records · Page 5Linked to original sources
PubMedDate not supplied

Effect of steroid therapy in experimental head trauma.

Since steroid therapy has been mostly utilized on an empirical basis in the management of head injury, this experimental study to assess the efficacy of steroid therapy was performed. Swiss-Webster mice (n = 85) were given 0.2 m of 50% ethanol intraperitoneally (IP) and lightly anaesthetized with ether. Ten randomly chosen mice were set aside and received no further treatment (non-head injury controls: Group A). The remaining mice (n = 75) were subjected to head injury and the survivors at 30 minutes (n = 52) were assigned randomly to two Groups, B and C. Group B was given 0.1 ml of saline IP at 30 minutes, 28 hours and 48 hours post-injury. At similar time intervals, animals in Group C received methylprednisolone 30 mg/kg IP. All animals were observed up to seven days and the number of survivors in each group recorded. All ten animals in Group A survived seven days. The daily mortality in Groups B and C were similar, and all animals were dead at seven days. Steroids were not found to be efficacious in this animals model.

Alcoholic Intoxication↗
PubMedDate not supplied

Effects of pentazocine in experimental head injury.

In previous studies we demonstrated the adverse effects of ethyl alcohol in murine head injury. Using this model in this study, effects of prior administration of pentazocine (Talwin) on the survival of mice are reported. Swiss Webster mice were randomly divided into one of three groups. Group I (n = 20) received pentazocine and Group II (n = 20, controls) received saline. Groups I and II were then injured under ether anaesthesia by allowing a weight to fall from a height of 15 cm on the cranium. Ten animals received pentazocine and were anaesthetized but had no head trauma (Group III). In Group II, 85% survived 24 h, and in Group I, 35% survived; all mice in Group III survived 24 h (significance: chi 2, p less than 0.005; Group I versus Groups II and III). Pentazocine increases the lethality of murine head injury.

Animals↗