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Biomedical subjects

C R Reddy

Publications and source records attributed to C R Reddy.

At least 55 records · Page 3Linked to original sources

Correlative study of exfoliative cytology and histopathology of oral carcinomas.

Cytology smears from 325 oral carcinomas were studied; the false-negative rate was 37%. Cancers of the floor of mouth exfoliated most malignant cells and those of the gingiva exofoliated the least. There was no correlation between the histologic grading, location, sex of the patient, and the result of the cytology smear. Oral exfoliative cytology should only be used as an adjunctive measure and is not a substitute for biopsy.

Cheek↗

Prevalence of carcinoma of the penis with special reference to India.

The frequency of carcinoma of the penis throughout the world is tabulated and compared with similar data from 32 hospitals in India. There is a wide variation in the frequency of penile carcinoma in India despite the fact that circumcision is not practiced by Hindus and is by Muslims. There must be some other etiologic factors such as poor sexual hygiene and lack of cleanliness to account for this variability in frequency. There was no association between the frequency of cervical and penile carcinomas.

Africa↗

Cysts of the jaws.

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Clinical Trials as Topic↗

Studies on mechanisms of hypocalcemia of magnesium depletion.

Studies were carried out to evaluate the mechanism of hypocalcemia in magnesium depletion. Day old chicks fed a magnesium deficient diet developed marked hypocalcemia, with a direct relation between serum calcium (y) and magnesium (x): y = 2.68 x + 4.24, r = 0.84 (both in mg/100 ml). Injections of parathyroid extract that increased serum calcium 2-3 mg/100 ml in normals had no effect in Mg-depleted birds. Very large dietary supplements of calcium or vitamin D(3) increased mean serum calcium only from 5.3 to 7.7 and 7.8 mg/100 ml, respectively, while a normal magnesium diet for 3 days increased calcium from 5.3 to 9.9 mg/100 ml despite absence of dietary calcium. Intestinal calcium transport, studied in vitro, and the calcium concentration of the carcass was significantly increased in magnesium-depleted chicks, making it unlikely that reduced intestinal absorption of calcium caused the hypocalcemia. In magnesium-deficient chicks, the bone content of magnesium was decreased by 74%, the calcium content was unchanged, and the cortical thickness of bone was markedly increased. After 3 days of magnesium-repletion, cortical thickness was reduced with increased endosteal resorption. There was an increase in unmineralized osteoid tissue in the magnesium-depleted chicks. Parathyroid gland size and histology did not differ in magnesium-depleted and control birds. The results suggest that hypocalcemia develops due to altered equilibrium of calcium between extracellular fluid and bone, favoring increased net movement into the latter. Failure of parathyroid gland function could also exist, and unresponsiveness to parathyroid hormone (PTH) may also contribute to the hypocalcemia. However, failure of PTH action is probably due to the presence of excess osteoid tissue rather than a primary event leading to hypocalcemia.

Animals↗