Immunoassay of human insulin and growth hormone simultaneously using I-131 and I-125 tracers.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
C R Morgan
Publications and source records attributed to C R Morgan.
Effect of insulin antibodies on pancreatic islet insulin and beta cell granule content.
Explore the source record for details and available documents.
Animals↗
Immunoassay of pancreatic and plasma insulin following alloxan injection of rats.
Explore the source record for details and available documents.
Alloxan↗
Growth hormone and insulin during oxandrolone therapy of stunting.
Explore the source record for details and available documents.
Arginine↗
Serum free fatty acids, growth hormone, and insulin during trials of ACTH and synthetic subunits.
Explore the source record for details and available documents.
Adrenocorticotropic Hormone↗
Clinical application of the thymidine incorporation assay.
An improved method for testing human tumors against chemotherapeutic agents was developed. Drug effects were quantitated in the thymidine incorporation assay (TIA) by measuring inhibition of deoxyribonucleic acid (DNA) synthesis by the proliferating cell population following exposure to anticancer drugs. Results were obtained within five days. A total of 480 out of 568 tumors received were evaluable for an overall growth rate of 85 percent. Even small biopsy specimens could be successfully grown. In 126 correlations with clinical response, the TIA had a prediction accuracy for sensitivity of 51 percent and a prediction accuracy for resistance of 97 percent. Because it is rapid, has a high growth rate, and is not subject to clumping and other cellular artifacts, the TIA represents a significant improvement over colony counting assays for predicting drug effects in human tumors.
Antineoplastic Agents↗