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Biomedical subjects

C R Martin

Publications and source records attributed to C R Martin.

43 records · Page 3Linked to original sources
PubMed1983

Acute myocardial infarction in sickle cell anemia.

Typical acute myocardial infarction in a well-documented case of sickle cell disease, to our knowledge, has not been reported. A patient with hemoglobin SS proved by electrophoresis with typical clinical manifestation and diagnostic ECG changes died suddenly. Autopsy findings were confirmatory, but no atherogenic lesions were present. Possible mechanisms for acute infarction are discussed, including sludging of sickle cells, coronary spasm, thrombus formation, and severe anemia associated with any or all of the aforementioned.

Adult↗
PubMedDate not supplied

Hemolytic-uremic syndrome and T-cryptantigen exposure by neuraminidase-producing pneumococci: an emerging problem?

Hemolytic anemia, thrombocytopenia, and renal failure form a constellation of complications observed in patients infected with neuraminidase-producing pneumococci. The circulating enzyme causes exposure of the T-cryptantigen on cell surfaces to which most people possess a naturally occurring antibody. Antigen-antibody interaction activates effector systems that lead to the clinical manifestations. The syndrome is most frequently seen in infants, in whom it carries more than a 50% mortality rate. T-cryptantigen activation can be detected by demonstrating red cell agglutination by the peanut lectin Arachis hypogea. Plasma exchange and avoidance of blood products containing immunoglobins are of value in the management of this devastating complication of pneumococcal infection.

Antigens↗