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Biomedical subjects

C R Laverty

Publications and source records attributed to C R Laverty.

32 records · Page 2Linked to original sources
PubMed1977

Clear cell adenocarcinoma of the uterine cervix: a histological and histochemical study.

A case of Mullerian clear cell adenocarcinoma of the uterine cervix occurring in a young women is presented. A detailed histological and histochemical study of this type of tumour is important so as to separate it from the clear cell tumour of mesoenphric origin. The association of Mullerian clear cell adenocarcinoma and other abnormalities of the vagina and cervix with the administration of maternal nonsteroidal oestrogens has been recently stressed in the literature. However, our patient is illustrative of the 30-50% of cases reported to date which have few if any of the associated abnormalities of the genital tract and have no known exposure to non-steroidal oestrogens.

Adenocarcinoma↗
PubMed1975

Uterine fibroid: an unusual cause of recurrent haemorrhagic pleural effusion.

A 51-year-old woman presented with dyspnoea due to pleural effusion, which repeatedly reaccumulated rapidly after tapping. A pelvic mass was present and she was considered to have disseminated ovarian malignant tumour. Total hysterectomy with bilateral salpingo-oophorectomy was performed, and the tumour was shown to be a necrotic uterine fibromyoma. After the operation the patient has been well, with no recurrence of the effusion. This is the twelfth reported case of the association of hydrothorax with uterine fibromyoma, and is a form of the rare pseudo-Meigs' syndrome.

Female↗
PubMedDate not supplied

Sampling, sampling errors and specimen preparation.

To obtain an adequate cervical smear for making a correct cytologic diagnosis, smear taking, laboratory handling and interpretation must be optimal. Many people are involved, and only by a combined effort of all links can this target be seriously approached: the smear takers will have to be open minded about technical improvements and read the morphologic descriptions cautiously; in the laboratory, cytotechnicians and physicians will have to challenge themselves and each other. It is mandatory to discard specimens that do not meet general standards of adequacy. At present a host of new techniques are being implemented. It is not feasible for all laboratories to be engaged in testing these new methods, but we are all requested to follow the development the best we can and switch to new ways when justified. Our working conditions are very different; therefore, it is our professional responsibility and plight to respond at the right time. So far the conclusion is that the conventional Pap smear is the international standard of care for the diagnosis of cervical cancer precursers in cancer screening programs. Certainly, this may change within a very short time. Liquid-based techniques, and in particular HPV technologies, are just around the corner.

Cell Biology↗
PubMedDate not supplied

Comparison of ThinPrep and Pap smear in relation to prediction of adenocarcinoma in situ.

OBJECTIVE: To compare the accuracy of reporting split-sample ThinPrep (SSTP) and the Pap smear (PS) in cases of histologically confirmed adenocarcinoma in situ (AIS) and to ascertain the reasons for any discrepancies. STUDY DESIGN: Comparison of prospective PS and ThinPrep (TP) predictions with unblinded review of TP slides. RESULTS: In 30 paired cytologic samples, AIS was originally accurately predicted by PS in 20 (67%) and SSTP in 14 (47%). In the 16 cases in which SSTP failed to predict AIS, on review 4 were regarded as cytologic undercalls, and in the remaining 12 no diagnostic material was found on the first TP slide. In eight of these, further TP slides were made; in three, diagnostic material was present on subsequent TP slides, and in five it was not. Differences in cytologic appearances of AIS were noted between TP and PS. CONCLUSION: Even though in routine practice SSTP did not perform as well as PS in predicting AIS, it has the potential to do so. These results cannot anticipate the performance of direct-to-vial TP with respect to prediction of AIS.

Adenocarcinoma↗
PubMedDate not supplied

Adenovirus infection of the cervix.

A case is recorded in which intranuclear inclusions suggesting adenovirus infection were recognized in a routine Papanicolaou smear. The patient was recalled for virologic studies and adenovirus type 19 was cultured from the cervix. The patient had a recent history of systemic illness with conjunctivitis, and a friend had conjunctivitis at the same time which was also proven to be due to adenovirus of the same serotype. This is the first reported instance in which adenovirus infection of the cervix suspected on cytologic findings has been confirmed by virus culture.

Adenoviridae Infections↗
PubMedDate not supplied

Electron microscopic detection of papilloma virus particles in selected koilocytotic cells in a routine cervical smear.

A routine cervical smear from a 56-year-old postmenopausal woman showed appearances indicative of papilloma virus infection with atypia. In an attempt to prove the diagnosis, the smear was reprocessed for electron microscopic examination. The reprocessing technique is described. Ultrastructural preservation was poor, and significant shrinkage was observed. In spite of these technical difficulties it was possible to prove that the selected cells in the smear contained papilloma virus particles. The virus particles seen were intranuclear in location and spherical in shape with a diameter of 40 to 50 nm. As was demonstrated in this case, the technique described will prove useful in evaluating the reliability of various diagnostic criteria for identifying viral infections in routine smears. This will apply particularly in cases where cultural confirmation of a reported viral infection is not possible.

Animals↗
PubMedDate not supplied

The significance of noncondylomatous wart virus infection of the cervical transformation zone. A review with discussion of two illustrative cases.

The clinicopathologic features are described of two patients whose cervical cytology smears showed features which were thought initially to indicate dysplasia, but which were later considered to be those of condylomata acuminata. One patient was an immunosuppressed renal transplant recipient, the other was a routine gynecologic clinic patient. No condylomas were recognizable clinically, and colposcopy showed only a flat but atypical transformation zone. Biopsy in each case showed a noncondylomatous warty lesion and wart virus particles were demonstrated by electron microscopy. These cases highlight the clinical, colposcopic, cytologic and histologic diagnostic difficulties which are encountered with cervical transformation zone wart virus infections, which are commoner than formerly realized. The possible relationship of wart virus infection to cancer of the cervix is also discussed.

Adult↗