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Biomedical subjects

C R Lamb

Publications and source records attributed to C R Lamb.

At least 55 records · Page 3Linked to original sources
PubMed1995

Cholecystokinin-8 induces edematous pancreatitis in dogs associated with short burst of trypsinogen activation.

To study the early pathogenesis of acute edematous pancreatitis in dogs, we examined the relationship of pancreatic hyperstimulation with cholecystokinin-8 (10 micrograms/kg/hr intravenously for 6 hr) to alterations in circulating pancreatic enzymes and pancreatic morphology with special reference to trypsinogen activation. Cholecystokinin-8 infusion was associated with increases in plasma amylase, lipase, trypsin-like immunoreactivity, and plasma and urine trypsinogen activation peptide. Pancreatic parenchymal swelling and interlobular and subcapsular fluid accumulations were detected ultrasonographically within 2 hr of cholecystokinin-8. Circulating trypsin-like immunoreactivity and trypsinogen activation peptide in urine reached a peak at 2 and 4 hr, respectively, then declined despite progressive increases in circulating amylase and lipase and intrapancreatic fluid. No significant changes were observed in dogs receiving a saline infusion. This study illustrates that cholecystokinin-8 induces edematous pancreatitis in dogs that is associated with a short-lived burst of trypsinogen activation.

Acute Disease↗
PubMed1994

Osteomyelitis and disseminated infection caused by Corynebacterium renale in a goat.

A 1.5-year-old female goat was examined for recurrence of lameness involving the right forelimb. Radiography of the thorax and right scapulohumeral joint revealed a pathologic fracture of the supraglenoid tubercle, and circumscribed radiolucent lesions in the right third and fourth ribs, and the base of the spinous process of T3. Bone scintigraphy demonstrated additional lesions in the lumbar spine and the wings of the ilium. At necropsy, disseminated infection and hematogenous osteomyelitis were diagnosed. Corynebacterium renale was cultured from the rib lesions. In food animals, osteomyelitis usually develops secondary to traumatic wounds, and members of the genus Actinomyces are frequently incriminated as the causative organism. This case is unusual because the osteomyelitis was unrelated to a traumatic wound, and the gross and microscopic lesions were reminiscent of caseous lymphadenitis, an infection caused by C pseudotuberculosis.

Animals↗
PubMed1994

Ultrasonography of the ureterovesicular junction in the dog: a preliminary report.

Contrast radiography followed by ultrasonography of the urinary bladder was performed on 10 incontinent dogs. The ureterovesicular junctions and ureteral jets were identified by ultrasonography in all the dogs except one that had a caudally displaced bladder. An ectopic ureter in one dog was diagnosed by ultrasonography on the basis of the absence of a ureteral jet on the affected side, and the direct identification of the ureter passing caudal to the bladder neck. Ultrasonography appears to be a simple, repeatable test for identifying the distal ureters.

Animals↗
PubMed1993

An application of sinography in small animal practice.

Sinography is a well recognised aid to clinical diagnosis in human medicine; it is used in equine practice but is less commonly used in small animal practice. The technique was used to investigate four dogs with sinuses associated with radiolucent foreign bodies secondary to penetration wounds.

Animals↗
PubMed1991

Contrast radiography of equine joints, tendon sheaths, and draining tracts.

Arthrography, tenography, and fistulography (or sinography) can provide additional information about the soft-tissue components of joints, tendon sheaths, and draining tracts, respectively. Arthrography is a valuable aid in the diagnosis of synovial masses, such as villonodular synovitis, and osteochondrosis. Tenography is particularly useful in evaluating chronic tendon sheath distention. Fistulography is an effective means of identifying acute traumatic damage to synovial structures and determining the cause and extent of draining tracts.

Animals↗
PubMed1991

Ultrasonography of the liver and biliary tract.

Evaluation of the liver and biliary tract is one of the principal applications of abdominal ultrasonography in small animals. Indications include hepatomegaly, mass in the area of the liver, suspected hepatic metastasis, jaundice, ascites, suspected diaphragmatic rupture, and weight loss. Ultrasonography is a valuable method for evaluating the internal structure of the liver and biliary tract. Certain functional assessments also may be made, for example, measurement of induced gallbladder emptying after cholecystokinin injection. Limitations of ultrasonography include lack of specificity for focal or multifocal hepatic lesions and insensitivity for certain infiltrative diseases, such as lymphosarcoma. These limitations contribute to diagnostic difficulties, which are adequately addressed only by biopsy. The technique of ultrasound-guided biopsy is described briefly.

Animals↗
PubMed1990

Bronchial dysgenesis and lobar emphysema in an adult cat.

An adult male cat was examined because of chronic respiratory tract disease. Results of thoracic radiography indicated overinflation of the right lung, and atelectasis or agenesis of the left lung. Notable aerosol deposition (ventilation) to the right caudal lung lobe was seen by use of pulmonary ventilation scintigraphy. Postmortem findings suggested the primary pathoanatomic lesion was bronchial dysgenesis involving all but the right caudal lung lobe.

Animals↗
PubMed1990

Preoperative measurement of canine primary bone tumors, using radiography and bone scintigraphy.

Specimens of 20 canine primary bone tumors (18 osteosarcoma, 2 fibrosarcoma) were examined to compare the maximal axial length of gross tumor with the length of the lesion seen on preoperative radiographs and 99mTc methylene diphosphonate bone scintigraphic images. Radiographs defined the length of the tumor to within +/- 10% of the gross measurement for 6 (30%), underestimated it for 12 (60%), and overestimated it for 2 (10%) specimens. Bone scintigraphy defined tumor length within +/- 10% for 8 (40%), underestimated it for 1 (5%), and overestimated it for the remaining 11 (55%) specimens. Use of radiographic evaluation alone could result in underestimation of the diaphyseal extent of a primary bone tumor, with risk of incomplete resection. Bone scan images tend to overestimate tumor length and, therefore, may provide safer resection guidelines.

Animals↗
PubMed1990

Reduction of hydronephrosis and hydroureter associated with ectopic ureters in two dogs after ureterovesical anastomosis.

Severe hydronephrosis and hydroureter associated with ectopic ureters were diagnosed in 2 dogs. Surgical transplantation of the ectopic ureters into the urinary bladder resulted in urinary continence in both dogs. Intravenous urography revealed a marked decrease in the size of hydronephrosis and hydroureter in both dogs 28 to 35 weeks after surgery. In 1 dog with bilateral ureteral ectopia, kidney size and renal function remained normal for 5 years after surgery. A dog with one ectopic ureter and an associated ureterocele had a marked reduction in size of the affected kidney and an apparent decrease in function of that kidney, as indicated by decreased opacification on an intravenous urogram.

Anastomosis, Surgical↗
PubMed1990

Bone scintigraphy in the initial evaluation of dogs with primary bone tumors.

Bone scintigraphy was performed as part of an initial diagnostic evaluation of 70 dogs admitted with primary bone tumors during a 2-year period. Tumors involved major long bones of the appendicular skeleton and included 62 osteosarcomas, 6 fibrosarcomas, and 2 chondrosarcomas. All dogs were free of radiographically detectable pulmonary metastases. Bone scintigraphy was not of value in distinguishing among various types of primary tumors. One dog with an ulnar chondrosarcoma had a scintigraphically detectable occult osseous metastasis or synchronous primary tumor, and 1 dog with osteosarcoma had a scintigraphically detectable lymph node metastasis. Pulmonary metastases were not detected scintigraphically. Of the 70 dogs, 44.3% had areas of increased isotope uptake associated with nonneoplastic disease processes.

Animals↗
PubMed1988

Prostatic adenocarcinoma with osseous metastases in a dog.

Bone scintigraphy was used to diagnose osseous metastasis of prostatic adenocarcinoma in a 10-year-old dog with neck pain and ataxia and a large, sensitive prostate gland. Although radiography revealed a normal spine, prostatic fluid cytologic and ultrasonographic findings were compatible with prostatitis or neoplasia. Scintigraphic hot spots were seen in the axial skeleton, ribs, pelvis, humerus, and femur and corresponded to sites of metastatic prostatic adenocarcinoma.

Adenocarcinoma↗