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Biomedical subjects

C R Howard

Publications and source records attributed to C R Howard.

119 records · Page 7Linked to original sources
PubMed1975

Transmission of hepatitis B to the rhesus monkey.

The rhesus monkey does provide a suitable laboratory animal model for studying hepatitis B virus and for investigating various aspects of interaction between this infectious agent and the host. This species of non-human primate, however, offers a less sensitive animal model for hepatitis B infection than the chimpanzee.

Animals↗
PubMed1970

Oral cancer.

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Mouth Neoplasms↗
PubMedDate not supplied

The thermal stability of yellow fever vaccines.

The assessment of yellow fever vaccine thermostability both in lyophilized form and after reconstitution were analyzed. Two commercial yellow fever vaccines were assayed for their thermal stability. Vaccines were exposed to test temperatures in the range of 8 degrees C to 45 degrees C. Residual infectivity was measured by a plaque assay using Vero cells. The titre values were used in an accelerated degradation test that follows the Arrhenius equation and the minimum immunizing dose was assumed to be 10(3) particles forming unit (pfu)/dose. Some of the most relevant results include that (i) regular culture medium show the same degradation pattern of a reconstituted 17D-204 vaccine; (ii) reconstituted YF-17D-204 showed a predictable half life of more than six days if kept at 0 degrees C; (iii) there are differences in thermostability between different products that are probably due to both presence of stabilizers in the preparation and the modernization in the vaccine production; (iv) it is important to establish a proper correlation between the mouse infectivity test and the plaque assay since the last appears to be more simple, economical, and practical for small laboratories to assess the potency of the vaccine, and (v) the accelerated degradation test appears to be the best procedure to quantify the thermostability of biological products.

Drug Stability↗