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Biomedical subjects

C R Hay

Publications and source records attributed to C R Hay.

60 records · Page 4Linked to original sources
PubMed1987

Atypical bullous pyoderma gangrenosum associated with myeloid malignancies.

Atypical bullous pyoderma gangrenosum was diagnosed during the course of a myeloid malignancy in three patients. One patient had chronic myeloid leukaemia, one acute myeloid leukaemia, and the third, refractory anaemia with excess of blasts. This atypical form of pyoderma gangrenosum has been specifically associated with myeloid malignancies. The atypical appearance of the skin lesions and the clinical context in which they arose caused the true diagnosis to be delayed in all cases. Treatment with steroids was associated with rapid healing of the skin lesion. The histopathological changes in the skin biopsy specimens from these cases were non-specific, and although the histology was considered to be atypical of pyoderma gangrenosum in one case, the unusual features could be attributed to the patient's neutropenia. (Skin biopsy was performed to exclude other specific pathology). Atypical bullous pyoderma gangrenosum is an uncommon association of the myeloid malignancies. It may remain unrecognised and should be considered more often.

Adult↗
PubMed1987

Predictive markers of chronic liver disease in hemophilia.

In an attempt to predict progressive liver damage in hemophiliac patients by noninvasive means, we conducted a retrospective analysis of clinical and laboratory data from 44 liver biopsies taken from 35 hemophiliac patients. This showed that serum IgG was normal in patients with chronic persistent hepatitis (CPH) but significantly elevated in those with chronic active hepatitis (CAH) or cirrhosis (CIR) (P less than .001). Relationships were less significant between liver histology and IgM (P less than .01), IgA (P less than .05), and globulin (P less than .05). This was unaffected by human immunodeficiency virus (HIV) antibody status in asymptomatic individuals. Although patients with progressive liver disease were also older than those with CPH (P less than .001), the immunoglobulin abnormalities were independent of this. Neither clinical examination nor liver biochemistry at the time of biopsy were of significant diagnostic value. Our results indicate that in the absence of AIDS an elevated IgG level is a reliable indicator of progressive hemophilic liver disease.

Adolescent↗
PubMed1985

Progressive liver disease in haemophilia: an understated problem?

In an 8-year study of 79 unselected patients with haemophilia who had received clotting factor concentrates, there was evidence of chronic progressive liver disease in at least 17 (21%). 8 patients had chronic active hepatitis and 9 had cirrhosis (5 with oesophageal varices). Histological evidence suggested that non-A non-B hepatitis was mainly responsible, although the influence of other viruses could not be excluded. Serial liver biopsies showed progression from chronic persistent hepatitis to chronic active hepatitis and cirrhosis within 6 years, suggesting that chronic persistent hepatitis in haemophiliacs is not as benign as hitherto supposed. Symptoms and abnormal physical signs were uncommon in these patients. There was no relation between degree of abnormality of serum aminotransferase levels and severity of the underlying liver disease. It is anticipated that liver disease in haemophiliacs will become an increasing clinical problem in the future.

Adolescent↗
PubMed1982

Effect of fish oil on platelet kinetics in patients with ischaemic heart disease.

The effect of taking fish oil rich in eicosapentaenoic acid on platelet kinetics was studied in 13 patients with ischaemic heart disease. No other change in diet, medication, or smoking habits was permitted. The fish oil provided 3.5 g of eicosapentaenoic acid a day. After 5 weeks the fish oil caused a 10% lengthening in platelet survival time, a 15% fall in platelet count, a 75% fall in plasma levels of platelet factor 4, and a 30% fall in plasma-beta-thromboglobulin. These findings suggest that a diet rich in omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid, will reduce platelet/vessel-wall interaction and may reduce the risk of ischaemic heart disease. Long-term studies to explore the toxicity and alleged protective effects of fish oil are justified.

Adult↗