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Biomedical subjects

C R George

Publications and source records attributed to C R George.

At least 19 recordsLinked to original sources
PubMed1995

Calcification of cervical ganglia: case report.

We describe a 44-year-old woman with progressive cervical pain in whom plain films of the cervical spine showed only minor syndesmophyte formation when the patient first presented. However, after 5 weeks, repeat films demonstrated heavy symmetrical calcification of the cervical dorsal root ganglia. A review of the literature did not reveal a previous description of these findings.

Adult↗
PubMed1995

Evaluation of a communication course for new hearing aid users.

A communication course for new hearing aid users, covering explanations of hearing loss and hearing aids, hearing tactics, lipreading and relaxation techniques in three 2 h sessions, was developed. The course was tested on groups of adults fitted with NHS post-aural hearing aids at the Audiology Clinic at the Royal South Hants Hospital. The course content, presentation, length and pace were evaluated by means of a questionnaire given at the end of the last session, and the effects on aid usage, satisfaction and benefit ratings were assessed by pre- and post-fitting questionnaires given to those who attended and to a matched group of control subjects. The course was offered to 41 men and 46 women. The acceptance rate was rather higher for women than for men, but attendance rates were similar for both sexes, men attending 33% and women 36% of the sessions offered. No relationship was observed between age or degree of hearing loss and rates of acceptance and attendance. All those who completed the evaluation questionnaire were satisfied with the content, length, pace and presentation of the course, and considered that it had helped them to understand and cope with their hearing loss. Most (28 out of 31) felt that they would use their aids more as a result of the course. However, their aid usage and ratings of benefit derived from the aids did not differ significantly from those of a matched group of controls who were not offered the course.

Aged↗
PubMed1994

Effects of erythropoietin therapy on the lipid profile in end-stage renal failure.

To evaluate the effects of erythropoietin (EPO) therapy on the lipid profile in end-stage renal failure, we undertook a prospective study in patients on both hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). One hundred and twelve patients (81 HD, 31 CAPD) were enrolled into the study. Lipid parameters [that is, total cholesterol and the LDL and HDL subfractions, triglycerides, lipoprotein (a), apoproteins A and B], full blood count, iron studies, B12, folate, blood urea, aluminium and serum parathyroid hormone were measured prior to commencement of EPO therapy. Ninety-five patients were reassessed 5.2 +/- 0.3 (mean +/- SEM) months later and 53 patients underwent a further assessment 13.1 +/- 0.6 months after the commencement of EPO, giving an overall follow-up of 10.0 +/- 0.6 months in 95 patients. As expected, EPO treatment was associated with an increase in hemoglobin (7.7 +/- 0.1 vs. 9.9 +/- 0.2 g/dl; P < 0.001) and a decrease in ferritin (687 +/- 99 vs. 399 +/- 69 micrograms/liter; P < 0.01). A significant fall in total cholesterol occurred (5.8 +/- 0.1 vs. 5.4 +/- 0.2 mmol/liter; P < 0.05) in association with a fall in apoprotein B (1.15 +/- 0.04 vs. 1.04 +/- 0.06; P < 0.05) and serum triglycerides (2.26 +/- 0.14 vs. 1.99 +/- 0.21; P < 0.05) during the course of the study. Other lipid parameters did not change, although there was a trend towards improvement.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1994

The effect of pre-fitting counselling on the outcome of hearing aid fittings.

The effect of pre-fitting counselling on the outcome of fittings of NHS behind-the-ear hearing aids to adult first-time users was investigated. Questionnaires and diaries were sent both before and after fitting to 48 subjects who were given pre-fitting counselling and 47 control subjects, all of whom were fitted with standard NHS hearing aids in Southampton or Bath between September 1989 and July 1991. The test and control groups had similar distributions of age, sex and hearing loss. Analysis of the data showed that the counselling had no significant effect on levels of satisfaction, aid usage or benefit; these outcome measures also showed no significant correlation with any of the personal characteristics or attitude factors which were studied.

Aged↗
PubMed1993

Aluminum kinetics using bicarbonate dialysate with the sorbent system.

In the REDY system a sorbent cartridge is used to regenerate the spent hemodialysate so that only six liters of dialysate are required for a treatment. The manufacturer claims that the cartridge can be used to remove aluminum from the dialysate and that it does not add aluminum to the dialysate. This claim for acetate dialysate is supported by the literature, but there are few data available relative to bicarbonate dialysate. The present study evaluates the use of bicarbonate dialysate and the REDY system in regard to aluminum kinetics both in vitro and in vivo. In vitro, the sorbent cartridge removed aluminum from dialysate prepared from water containing as much as 470 micrograms/liter of aluminum, giving a dialysate containing less than 10 micrograms/liter. The first 500 ml of effluent contained 13 micrograms/liter of aluminum but after filtration decreased to below 10 micrograms/liter. Thus, it is unnecessary, as recommended, to discard the first effluent since this unfilterable aluminum will not pass through a dialysis membrane. In vivo, in a crossover study comparing the REDY with single pass, there were no significant differences between the pre- and post-plasma aluminum concentrations, and the dialysate aluminum remained below 4 micrograms/liter during the dialysis. In a second in vivo study the effect of dialysate from tap water on plasma aluminum using the predialysis purification procedure was evaluated. There was no differences between the pre- and post-plasma aluminum concentration. The aluminum levels were comparable to those of the crossover study. The dialysate remained below 4 micrograms/liter during the dialysis.

Absorption↗
PubMed1992

Noncytotoxic drug therapy for intra-abdominal desmoid tumor in patients with familial adenomatous polyposis.

Forty of 416 patients with familial adenomatous polyposis were noted to have intra-abdominal desmoid tumors, and a subgroup of 16 were treated with noncytotoxic drug therapy. Drugs used were sulindac (14 patients), sulindac plus tamoxifen (3 patients), indomethacin (4 patients), tamoxifen (4 patients), progesterone (DEPO-PROVERA; Upjohn Co., Kalamazoo, MI) (2 patients), and testolactone (1 patient). Therapy with these drugs for continuous periods of six months or more resulted in three complete and seven partial remissions. When treated patients were compared with untreated patients (n = 12), there were significant benefits for the treated group, both in reduction of desmoid size and in improvement of symptoms, despite the inherent selection bias against this. Sulindac was the only drug used in enough patients to permit independent evaluation of its effect, with one complete and seven partial reductions of tumor size. Some patients had a delayed response to sulindac, with tumor shrinkage occurring after an initial period of tumor enlargement. When using sulindac for the treatment of desmoid tumors, this phenomenon should be considered.

Abdominal Neoplasms↗
PubMed1988

Follicular aspiration: a comparison of an ultrasonic endovaginal transducer with fixed needle guide and other retrieval methods.

Ultrasonic techniques have been developed as alternatives to conventional laparoscopic aspiration for oocyte retrieval for in vitro fertilization (IVF). Given the advantages (less risk, lower cost, and greater patient acceptance) of these alternative techniques, it is appropriate to assess their efficacy compared with traditional laparoscopic retrieval. This article examines the recovery rate of oocytes and their subsequent fertilization rate with the use of an ultrasonic endovaginal transducer with fixed needle guide and compares these results with other retrieval methods. Comparisons were made between laparoscopic harvesting (n = 71, group I), ultrasonic transabdominal transvesical (n = 21, group II), and ultrasonic vaginal transducer (n = 76, group III). The data demonstrate comparable success using an ultrasonic endovaginal transducer with fixed needle guide. The authors believe this technique to be the procedure of choice for all routine oocyte retrievals during IVF treatment.

Female↗