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Biomedical subjects

C R Garcia

Publications and source records attributed to C R Garcia.

At least 55 records · Page 3Linked to original sources

Adolescent contraceptive use: comparisons of male and female attitudes and information.

Information and attitudes about contraception and pregnancy were assessed with a self-administered questionnaire in a sample of urban Black teenagers. Data were obtained from 607 male and female students in high school health classes and a demographically similar group of 123 never-pregnant teenage women in a family planning clinic who had not attended these classes. Males were less likely to recognize the risk of pregnancy, had less information about contraceptives, and fewer attitudes that supported contraceptive use than females who participated in the same shool health classes. More males than females indicated that school classes had been the main source of contraceptive information. Teenage women in the family planning clinic did not differ from the high school females in attitudes about contraceptives, but the school group had somewhat more contraceptive information. The female school group was more likely to have discussed contraception with parents, obtained more contraception information from their mothers, and discussed contraception more with male friends than the teenagers who requested contraceptives at the family planning clinic.

Adolescent↗

Emotional distress patterns among women having first or repeat abortions.

Thirty-five percent of a sample of 413 women undergoing first-trimester abortions were repeating abortions. All patients rated their emotional symptoms on an SCL-90 scale and completed a brief demographic questionnaire. Preabortion and postabortion emotional distress factors and associated demographic characteristics were compared for women having first and those undergoing repeat abortions. Elevated distress levels were similar in both groups prior to abortion procedures, particularly depression, anxiety, and somatization. After abortion, repeat aborters continued to have significantly higher emotional distress scores in dimensions relating to interpersonal relationships. The variables that discriminated most between first and repeat abortion groups were number of living children, race, and phobic anxiety.

Abortion, Induced↗

A synthetic steroid (R2323) as a once-a-week oral contraceptive.

Five milligrams of the steroid R2323 (13 beta-ethyl-17 alpha-ethynyl-17-hydroxygona-4,9,11-trien-3-one (R2323) were administered orally once weekly to 28 subjects for a total of 138 treatment cycles. No pregnancies occurred. The predominant side effects were irregular vaginal bleeding, headache, weight gain, and acne. Administration of the drug was stopped by the investigator in four patients (14%) because of the onset of headaches. Four patients discontinued the drug for other reasons. In 8 of 26 subjects (31%), endometrial biopsy in the third treatment cycle showed secretory endometrium. This suggests a variable central suppression with the 5-mg dose schedule. Patients were enthusiastic about the once-weekly oral administration. This contraceptive may be useful in a select group of women.

Adolescent↗

An infertility data registry.

A computerized infertility data registry form has been developed in order to facilitate the storage of a large amount of reproductive data to allow subsequent analyses pertinent to the managment of the infertile couple. This abstract form of the patients' medical records had been readily applied to computer analysis using the SPSS reporting system. The abstract can be utilized both for the facilitation of patient management and as a means for obtaining a standardized, objective, retrospective review of clinical data. Through the evaluation and standardization of the therapeutic techniques frequently utilized by physicians, the treatment of infertile couples should be improved. Such an approach is essential for anyone involved in today's health care system.

Female↗

Contraceptive steroids and liver lesions.

Concern has been expressed about the possible untoward effect of oral contraceptives on the liver. During the past 10 yr an increasing number of cases of hepatic adenomas and related lesions has been reported in women using oral contraceptives. Such lesions occur only rarely, but it is the rarity itself that makes it difficult to evaluate the role of the contraceptive steroids. The enormity of the denominator in contraceptive steroid usage is so unwieldy that mechanisms to measure accurately the difference in an extremely small numerator are still plaguing the epidemiologist, who at best can supply only estimates. The data to date support an exceedingly low incidence of disease. This is much below the greater risks faced in accepted activities of daily living, particularly as affected by pregnancy itself. A plea is made to develop programs for better prospective evaluations of newer medications along with better animal experimental models.

Chemical and Drug Induced Liver Injury↗

A comparison of endometrial histology with simultaneous plasma progesterone determinations in infertile women.

A retrospective analysis of 238 endometrial biopsies and simultaneous plasma progesterone determinations performed during the course of infertility evaluations is presented. The data suggest a high (93%) correlation between the two procedures for the detection of ovulation. Endometrial abnormalities were detected in 5% of the biopsies. Shortening of the cycle was noted in 36% of the patients, while only 3% demonstrated a longer cycle. Simultaneous measurement of plasma progesterone levels in association with the endometrial biopsy is believed to better document corpus luteum defects. One should be aware of the frequent occurrence of a shortened cycle on the basis of postbiopsy bleeding. Basal body temperature graphs should be utilized prior to biopsy in patients with a history of irregular menstrual cycles.

Endometrium↗

The effect of an extraluminal transducer on the reproductive capability of the rabbit.

An extraluminally attached microminiature force transducer, designed for reproductive tract contractility measurements, was investigated in terms of its effects on the physiology of the uterotubal junction in the rabbit. The presence or attachment process of the extraluminal force transducer (EFT) did not affect the rate of pregnancy or the number of embryonic implantation sites whether the attached device was silicone rubber or polyethylene-encased. The uterotubal junction was able to retain the blastocyst for the required time after mating, while an examination of postembryonic mortality revealed a rate of one resorption in some experimental groups. The gestation period was unaffected by the EFT, ranging from 30 to 40 days with a mode of 32, while histologic examinations revealed formation of a thin fibroblastic layer, some increased vascularity, and no abnormal leukocytic accumulation.

Animals↗

Endometrial biopsy in the cycle of conception.

The pregnancy outcome of 18 infertile patients inadvertently biopsied during the cycle of conception is reviewed. Fourteen patients delivered term infants, one a premature infant; one patient aborted during the first trimester, and two patients were lost to follow-up. The pregnancy outcome was better than that frequently quoted for infertile patients. A comparison of the present series with those previously reported is made and the author's technique for endometrial biopsy is discussed. The average duration of gestation is calculated using the endometrial biopsy.

Abortion, Incomplete↗