Biomedical subjects
C R Bamford
Publications and source records attributed to C R Bamford.
Percutaneous sciatic somatosensory evoked potential. A comparison to the transcutaneous response.
Cerebral and spinal evoked potentials were recorded in response to percutaneous stimulation of the sciatic nerve at the inferior gluteal crease. To justify the invasiveness of the procedure, a comparison was made to transcutaneous stimulation of the inferior gluteal nerve at the same level.
Bacterial meningitis--a possible complication of nasal continuous positive airway pressure therapy in a patient with obstructive sleep apnea syndrome and a mucocele.
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Menstrual-associated sleep disorder: an unusual hypersomniac variant associated with both menstruation and amenorrhea with a possible link to prolactin and metoclopramide.
A 42-year-old female presented with a history of hypersomnia associated with her menstrual periods. The menstrual periods abated coincident with the use of metoclopramide. The hypersomnolence, however, did not abate, but rather became more brief and erratic in its periodicity. The hypersomnolence was associated with marked elevations in the serum prolactin level.
Posterior tibial somatosensory evoked potentials from distal, middle and proximal lower limb stimulation. A comparative study.
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Carbamazepine in REM sleep behavior disorder.
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Neurologic complications of the tryptophan-associated eosinophilia-myalgia syndrome.
A case of tryptophan-associated eosinophilia, central nervous system complications, and multiple white matter lesions by magnetic resonance imaging is presented. Eosinophilia regardless of its cause should be included within the differential of patients exhibiting periventricular white matter lesions.
Deranged modulatory midbrain opioid and gonadotrophin functions: relevance to Tourette's syndrome.
In the following communication we discuss evidence suggesting that an abnormal opioid-gonadotrophin interaction at the midbrain may be essential to the clinical expression of vocal tics in Tourette's Syndrome (TS). Data derived from animal studies and the striking similarity between the symptomatology of TS and encephalitis lethargica (EL) add further support to our hypothesis implicating an abnormal opioid-gonadotrophin interaction in the pathophysiology of TS.
A prospective study of physical trauma and multiple sclerosis.
During an eight year period 170 multiple sclerosis (MS) patients and 134 controls without physical impairment were followed closely to record all episodes of physical trauma and to measure their effect on exacerbation rate and progression of MS. There was a total of 1407 instances of trauma, which were sorted into various categories. Overall there was no significant correlation between all-traumas and disease activity. There was, however, a statistically significant negative correlation between traumatic episodes and exacerbations in 95 patients who had exacerbations during the programme, due primarily to less activity of the disease during a three month period following surgical procedures and fractures. Electrical injury had a significant positive association with exacerbation using a three month at-risk period, but there were no other significant positive correlations in any other category of trauma, including minor head injuries; there were no cases of head injury with prolonged unconsciousness. There was no linkage between the frequency of trauma and progression of disability. MS patients had two to three times more trauma than controls.
Central and peripheral nervous system involvement in the L-tryptophan associated eosinophilia myalgia syndrome.
A case of L-tryptophan associated eosinophilia, myalgia, eosinophilic fasciitis, peripheral sensorimotor neuropathy, and multiple white matter lesions on MRI scan is reported. The various effects of eosinophilia on the nervous system are reviewed. The persistence of the neurological complications despite resolution of eosinophilia and steroid therapy is emphasized.
Serial epilepsy caused by levodopa/carbidopa administration in two patients on hemodialysis.
Two patients with similar clinical features are presented: both patients had chronic renal failure, on hemodialysis for many years but recently begun on a high-flux dialyzer; both had been receiving a carbidopa/levodopa preparation; and both had the onset of hallucinosis and recurrent seizures, which were refractory to anticonvulsants. The first patient died without a diagnosis; the second patient had a dramatic recovery following the administration of vitamin B6. Neither patient was considered to have a renal state sufficiently severe enough to explain their presentation.
Observations of the posterior tibial nerve SEP of patients requiring extradural spinal surgery.
The cortical potentials evoked by posterior tibial nerve stimulation were examined in a series of 141 hospital patients requiring extradural spinal surgery. One hundred and five patients were neurologically intact, while in 36 some deficit was present. In the intact subjects, the absolute latencies of the main medium-latency peaks (N30, P40, N50, P60) were found to vary with height and age. There were no additional gender-related differences. The latencies of the deficit group were longer than those of the intact group but only marginally useful as a clinical discriminator; their amplitudes were not significantly lower than those of the intact group. A model for variations in SEP latency is suggested.
Fluctuations of symptoms during manic-depressive mood changes in Tourette's syndrome.
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Inappropriate sexual behavior and denervation supersensitivity of limbic and midbrain LHRH receptors in Tourette's syndrome.
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The effects of baclofen in the restless legs syndrome: evidence for endogenous opioid involvement.
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Pain and sensory symptoms in Parkinson's disease.
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Beneficial effects of imipramine on Tourette's syndrome.
Gilles de la Tourette's syndrome (GTS) is a chronic neuropsychiatric disorder characterized by multiple involuntary motor and phonic tics associated with behavioural disturbances including obsessive-compulsive and aggressive behavior, depression and, rarely, psychosis. The relationship of GTS, presumed to be predominantly a dopaminergic disorder, and depression, presumed to be a noradrenergic-serotoninergic deficiency state, is currently poorly understood. The reports published to date on the effects of tricyclic antidepressants in GTS have been contradictory; while Messiha et al. (1976) used imipramine successfully in one GTS patient, Abuzzahab and Anderson (1973) and Fras (1978) on the other hand, found imipramine to exacerbate GTS symptoms and cautioned its usage in this syndrome. A more recent report suggested that imipramine is useful in GTS patients who exhibit symptoms of attention deficit disorder (Dillon et al., 1985). We report a patient with GTS whose depression and behaviour improved considerably when low-dose imipramine (Tofranil) was added to the regimen of anti-GTS medication. This report suggest that tricyclic antidepressants may be useful adjuncts in the management of GTS, and hints at norepinephrinergic and serotoninergic deficiencies as being components of the pathogenesis of the syndrome.
Deregulation of hypothalamic opioid and luteinizing hormone releasing factor (LHRF) activity and its relevance to Tourette's syndrome.
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