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Biomedical subjects

C R Angle

Publications and source records attributed to C R Angle.

At least 73 records · Page 4Linked to original sources
PubMed1975

Evaluation of suicide risk in adolescents.

Self-destructive behavior in the adolescent is a continuum that ranges from drug intoxications to gestures of low lethality to suicide attempts with high lethality of intent. Such behavior should be treated as a signal of long-term stress and strife. A "Psychological biopsy" is outlined for evaluation of the severity and type of perturbation. This focuses on 9 areas of inquiry: the circumstantial lethality of the event; prior self-destructive behavior; depression; hostility; stress; reaction of the parent or parent surrogate; loss of communication; lack of resources; and extremes of parental expectations and control. Adolescents under severe familial and socioeconomic stress, and with a history of acting-out behavior, often respond well to transfer to a more favorable home situation. In cases where there is no apparent familial perturbation, the physician should be alert to the possibility of severe psychiatric disorder. In either case, initial definition of the problem opens the way to a plan for management and support.

Adolescent↗
PubMed1974

Red cell lead, whole blood lead, and red cell enzymes.

Simultaneous assay of blood lead (Pb-B) and red cell lead (Pb-Rbc) in 123 samples from 104 urban and suburban students, ages 10-18, shows the ratio of concentration (Pb-Rbc)/(Pb-B) to increase as the hematocrit decreases. On direct assay in 40 samples, plasma lead (Pb-P) was fixed in a narrow range. In 28 students with Pb-Rbc >40 mug/100 ml, the mean red cell 2,3-diphosphoglycerate (2,3-DPG) was 6.05+/-0.28 (+/-S.E.), significantly higher (P<.025) than the 5.25+/-0.18 of 51 students with Pb-Rbc<40 mug/100 ml, although hemoglobin values were comparable (13.83+/-0.31 versus 13.55+/-0.20). Analysis of the individual population groups showed this correlation of Pb-Rbc with 2,3-DPG to be primarily related to the intercorrelation of each parameter with hemoglobin.Rbc membrane Na/K ATPase, as per cent of total membrane ATPase, had a median value of 60% in 48 subjects. Na/K ATPase below 60% was found in 10 (77%) of the 13 students with Pb-Rbc>/=40 mug/100 ml, but in only 14 of the 35 with Pb-Rbc<40 mug/100 ml (chi(2)=5.1, df=1, P<0.05). Correlation of significant enzyme changes with Pb-Rbc, but not with Pb-B in the normal urban range of Pb-B<35 mug/100 ml suggests Pb-Rbc, increased in anemia, to be a critical factor in the hematotoxicity of lead.

Adenosine Triphosphatases↗
PubMed1972

Air lead: relation to lead in blood of black school children deficient in glucose-6-phosphate dehydrogenase.

Forty-four black children at two elementary schools within 0.7 mile of a battery plant had significantly higher (P < .001) concentrations of lead in their bloods (34.1 +/- 9.7, micrograms per 100 milliliters, mean +/- standard deviation) than 122 students (26.3 +/- 7.1) at seven schools 1 to 3 miles distant; 5 months later there was a comparable difference between red cell lead values (54.1 +/- 18.5 versus 37.4 +/- 12.6). Among the blacks, those deficient in glucose-6-phosphate dehydro-genase had a higher (P < .005) concentration of lead in the blood after correction for anemia (32.9 +/- 9.7) than the nondeficient (25.7 +/- 8.8), and a higher concentration in the red cells (47.3 +/- 14.7 as compared to 35.6 +/- 15.8, P < .001); the enzyme effect was independent of geographic location.

Air Pollution↗