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Biomedical subjects

C Q Wang

Publications and source records attributed to C Q Wang.

31 records · Page 2Linked to original sources
PubMed1990

[Effects of microiontophoretically applied OMF on spontaneous discharges of respiration related units (RRUs) in the region of nucleus ambigus of rat].

In the present study, it was observed that ohmefentanyl (OMF) affected microiontophoretically applied spontaneous discharges of respiration related units (RRUs) in the nucleus ambigus of rats. Of 96 RRUS recorded, 48 units were depressed following OMF application, 14 units increased in discharges, 14 units increased and then decreased, 9 units decreased and then increased. The remaining 11 units were not influenced. Naloxone administered iontophoretically not only blocked OMF-induced depression in 11 out of 15 units, but blocked OMF-induced facilitation in 5 out of 6 units. U-50488 administered microiontophoretically antagonized OMF-induced depression in 9 out of 13 units. Duration of the depression produced by OMF was much longer than that of the facilitation. The result suggests that the subtype of opiate receptors mediating the depression seen to be different from that responsible for the facilitation.

Animals↗
PubMed1989

Hypocrellin-A sensitized photooxidation of bilirubin.

Hypocrellin A (HA) extracted from Hypocrellia bambusae (b.et Br.) sace, a derivative of 3,10-dihydroxy-4,9-perylenequinone, is a highly effective photosensitizer. Kinetic studies of the HA-sensitized photooxidation of bilirubin IX alpha (BR) in different solvents in the presence of various active oxygen quenchers indicate that in aprotic solvents the photooxidation goes via a Type II (1O2) mechanism, whereas in alkaline protic solvents Type I (electron transfer from an excited state of HA to the ground state of oxygen or the BR substrate). Type II and probably free radical reactions may occur simultaneously.

Bilirubin↗
PubMed1989

[Effects of ohmefentanyl on rat respiration].

The respiratory depression in rats induced by sc ohmefentanyl showed a ceiling effect, but a linear relation with log dose when applied into the dorsal medulla. It elicited, however, a marked excitation on respiration when applied to dorsal pons. This excitatory effect of ohmefentanyl was antagonized by naloxone, and it antagonized to some extent the respiratory depressant effect induced by ohmefentanyl itself applied on dorsal medulla. It was postulated that the respiratory excitatory effect of sc ohmefentanyl on dorsal pons may have a bearing on the ceiling effect of its respiratory depression.

Analgesics↗