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Biomedical subjects

C Price

Publications and source records attributed to C Price.

231 records · Page 13Linked to original sources
PubMedDate not supplied

Bioavailability in human volunteers of three intramuscular formulations of cefonicid: a long-acting cephalosporin.

Three different intramuscular formulations of cefonicid (a new long acting cephalosporin) have been tested for bioavailability in 12 healthy volunteers, using a triple crossover design. No significant differences were detectable between the bioequivalence of the three formulations in terms of area-under-curve and 24-h urinary excretion. However, one of the formulations (A) was absorbed significantly more rapidly from the site of injection, causing higher serum levels for up to 1.5 h after administration. A significantly greater urinary excretion was also found up to 8 h after administration of formulation A. All three formulations were well tolerated, and no side-effects or significant changes in laboratory tests were observed.

Adult↗
PubMedDate not supplied

Does pediatric orthopedic subspecialization affect hospital utilization and charges?

In the current climate of health care reform, there is a perception that overspecialization is responsible for increased medical costs. Few studies support the premise that high-quality surgical subspecialization improves the cost effectiveness of care. The purpose of this study was to compare hospital utilization and charges between a pediatric hospital staffed by pediatric orthopedic subspecialists and a community hospital system for the care of closed femur fractures and slipped capital femoral epiphysis (SCFE) in a pediatric population. We reviewed hospital charges and length-of-stay (LOS) data for all children treated for closed femoral shaft fractures and SCFE between 1992 and 1994 within the Intermountain Health Care System (IHC). Within the IHC, there are 23 community hospitals and one children's hospital (PCMC). Patients were matched for age and injury severity. Four of six orthopedic surgeons at PCMC are pediatric orthopedists, but none of the community orthopedists has subspecialty training in pediatric orthopedics. For closed femoral shaft fractures (n = 334), the average hospital charges were less (PCMC, $4,943/Other IHC, $9,031), and length of stay was shorter (PCMC, 2.81 days/Other IHC, 8.91 days) when the child was treated at the children's hospital by pediatric orthopedic subspecialists. For SCFE (n = 63), the average hospital charges were less (PCMC, $2,824/Other IHC, $3,544) and the length of stay was shorter (PCMC, 1.13 days/Other IHC, 1.64 days) at the children's hospital. These data suggest that hospital utilization and charges were significantly decreased if the care was provided by pediatric orthopedic subspecialists in a children's hospital.

Adolescent↗
PubMedDate not supplied

Symbolic anatomic knowledge representation in the Read Codes version 3: structure and application.

The Read Thesaurus (Version 3 of the Read Codes) is a controlled medical vocabulary produced during the Clinical Terms Projects with the involvement of over 2,000 health care professionals from all United Kingdom specialties. In addition to allowing the transfer of clinical information in a meaningful way, it supports analysis of this information and provides a basis for the development of shareable medical knowledge bases. The thesaurus includes a comprehensive, dynamic set of over 7,000 gross anatomic concepts richly linked in a network with over 16,000 operative procedures and 40,000 disorders. The representation of anatomic concepts aims to balance the requirements for expressivity, clearness, and simplicity. The underlying directed acyclic graph hierarchy is independent of the alphanumeric code and enables continued refinement and expansion. A template table allows semantic definition, qualification, and linkage of concepts.

Anatomy↗
PubMedDate not supplied

Updating the Read Codes: user-interactive maintenance of a dynamic clinical vocabulary.

The Read Codes are a hierarchically-arranged controlled clinical vocabulary introduced in the early 1980s and now consisting of three maintained versions of differing complexity. The code sets are dynamic, and are updated quarterly in response to requests from users including clinicians in both primary and secondary care, software suppliers, and advice from a network of specialist healthcare professionals. The codes' continual evolution of content, both across and within versions, highlights tensions between different users and uses of coded clinical data. Internal processes, external interactions and new structural features implemented by the NHS Centre for Coding and Classification (NHSCCC) for user interactive maintenance of the Read Codes are described, and over 2000 items of user feedback episodes received over a 15-month period are analysed.

Computer Systems↗
PubMedDate not supplied

Read Code quality assurance: from simple syntax to semantic stability.

As controlled clinical vocabularies assume an increasing role in modern clinical information systems, so the issue of their quality demands greater attention. In order to meet the resulting stringent criteria for completeness and correctness, a quality assurance system comprising a database of more than 500 rules is being developed and applied to the Read Thesaurus. The authors discuss the requirement to apply quality assurance processes to their dynamic editing database in order to ensure the quality of exported products. Sources of errors include human, hardware, and software factors as well as new rules and transactions. The overall quality strategy includes prevention, detection, and correction of errors. The quality assurance process encompasses simple data specification, internal consistency, inspection procedures and, eventually, field testing. The quality assurance system is driven by a small number of tables and UNIX scripts, with "business rules" declared explicitly as Structured Query Language (SQL) statements. Concurrent authorship, client-server technology, and an initial failure to implement robust transaction control have all provided valuable lessons. The feedback loop for error management needs to be short.

Clinical Medicine↗
PubMedDate not supplied

Perforation of an intraaortic balloon twice in one patient.

Perforation of an intraaortic balloon is a well recognised complication of the device and is usually due to abrasion by a calcified aortic atheromatous plaque. We report a case in which a replacement balloon also perforated and suggest that if continued balloon assistance is required, a lower perfill volume may prevent damage to the second balloon.

Aged↗
PubMedDate not supplied

The anatomy of the saphenous nerve in the lower leg with particular reference to its relationship to the long saphenous vein.

The anatomy of the saphenous nerve in the lower leg was studied in eighty patients undergoing saphenous vein aortocoronary bypass grafting. It is suggested that a knowledge of the described variations in the anatomical relationship of the saphenous nerve and vein should reduce the incidence of operative trauma to the saphenous nerve.

Coronary Artery Bypass↗
PubMedDate not supplied

MR imaging artifacts produced by dental materials.

This report evaluates a variety of dental materials with respect to MR imaging artifacts and their mechanisms of production. A 0.15-T superconducting system and an MR phantom were used in assessing imaging artifacts. Several in-vivo studies were also carried out. The dental materials were analyzed for composition and magnetic permeability and the results were compared with the artifacts produced by each material. It was found that the higher the magnetic permeability the greater the artifact produced. Magnetic permeability of a material is generally not predictable on the basis of its composition, however.

Dental Materials↗