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Biomedical subjects

C Powell

Publications and source records attributed to C Powell.

At least 109 records · Page 6Linked to original sources
PubMed1979

The induction of acute psychosis in a group setting.

The case histories of two patients are described, each of whom suffered a severe psychotic decompensation, one apparently schizophreniform and the other affective, after attending a seven day marathon group conducted by a charismatic, aggressive leader. The work of Yalom and Lieberman is reviewed, with regard to leader and participant characteristics in encounter group casualties. Drawing upon the work of Bion and Kernberg, a specific means for the induction of psychosis is suggested, involving primitive splitting and the projection of "all bad" self-object constellations within a group setting.

Adult↗
PubMed1978

Age related differences in the disposition of acetanilide.

1 The metabolism of fifteen elderly hospital in-patients and fifteen young people was studied, using a gas chromatography mass spectrometer method. 2 The results suggest that there is no significant change in hepatic oxidation of acetanilide with age. 3 The concentrations of metabolites were however, significantly elevated in the older group. 4 These results illustrate the importance of the decline in renal function with age in the disposition of drugs.

Acetanilides↗
PubMed1977

Plasma paroxonase activity in old age.

Genetic factors are known to be of importance in determining the rate of biotransformation of foreign compounds in the liver. Adverse reactions to drugs are increased and pharmacokinetic parameters altered with age. In the present study, the effect of age on plasma paroxonase activity is studied. Paroxonase is a hepatically synthesized enzyme whose activity is almost entirely determined by genetic factors. It therefore serves as a model to determine whether changes in the frequency or expression of genes could explain the altered responses to drugs observed with age. The frequency distribution for paroxonase activity for 186 elderly people is closely similar to that obtained from 190 blood transfusion volunteers and 189 family members. Paroxonase activity, as with all other previously investigated pharmacogenetic polymorphisms, is unchanged with age. The hypothesis is put forward that genetic determinants of drug metabolism remain unchanged with age.

Aged↗