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Biomedical subjects

C Portelli

Publications and source records attributed to C Portelli.

At least 19 recordsLinked to original sources
PubMed1983

The L-cell and D-cell of mitosis.

The two daughter cells produced by the mitosis of an eukaryotic cell present some patterns of organization with mirror-symmetry. For example, during the metaphase the succession of chromosomes in the ring of equatorial plate develop in the clockwise direction for the daughter D-cell and in the counter clockwise direction for the daughter L-cell. A similar mirror-symmetry is manifested between the patterns formed by the molecular receivers of the two daughter cells. This is a topological information, which interferes in the cellular differentiation and in the structural development of the polycellular organisms.

Chromosomes↗
PubMed1979

The origin of life. A cybernetic and informational process.

According to the model presented in this paper, the beginning of life was marked by the coupling of two complementary nucleotide bases: adenine and thymine. The adenine-thymine system received photons from the sun and stored their energy in the form of a chemical high-energy bond between two phosphoric acid molecules, which were before-hand fixed by adenine from the aqueous environment. The energy of the high-energy bond was then delivered in the form of two waves of electronic excitation. These were utilized to synthesize new molecules, starting from the carbonic acid and ammonia molecules, fixed from the aqueous environment by the polar groups of the nucleotide bases. In this way, a nucleotides-histone protosystem (NHPS) was self-synthesized, evolving step by step towards complexity, by means of some internal cybernetic and informational mechanisms. During its evolution, the NHPS synthesized a limiting membrane, produced the organizing elements of the cellular organelles (chloroplastes, mitochondria, ribosomes etc) and constructed microtubules and microfilaments. Subsequently, the NHPS evolved to the building of DNA-histone system and formed the cellular nucleus.

Adenine↗
PubMed1976

DNA-histones, a computer model.

The model of DNA-histones has the following elements: 1. The hydrogen bonds between the complementary nucleotide bases function as informational gates. When the electrons pi of one nucleotide base are excited, an exchange of protons is produced between the two complementary bases. The result is the displacement of the conjugated double bonds which facilitates the inter-molecular transmission of the electronic wave of excitation by electro-magnetic coupling. 2. Each triplet of nucleotide bases of DNA fixes one definite amino acid (as in the genetic code). Between the nucleotide bases and the amino acids there are constituted informational gates, which ensure the circulation of the electronic wave of excitation. 3. An input signal molecule arrives at the receiver gene and unleashes the activity of the enzymes which introduce in the DNA-histones system the electronic wave of excitation. The electronic wave of excitation arises as a result of the break of the high-energy bonds of ATP. Then, the electronic excitation is transmitted to the productor gene where it represents the signal for starting the synthesis of the mRNA.

Adenosine Triphosphate↗
PubMed1975

A model of the mechanisms of memory.

The neuronal information is formed by 2 waves: electronic and ionic, which enter the neuron at the level of the excited synapses. The neurofilaments lead to the transmission of the electronic wave, while the microtubules direct the ionic wave. Arriving at the level of the nuclear membrane, the electronic wave of excitation enters the system DNA-histones, which works as a computer. The electronic wave is retransmited to a bundle of neurofilaments, then it is carried to a certain collateral of the axon. In its movement, the electronic wave guides the ionic wave toward certain synapses, so that the specific connections between the input and the output signals are assured.

Brain↗
PubMed1975

DNA -a computer model.

The model of the system DNA-histones functioning like a computer has the following elements: 1. The hydrogen bonds between the complementary nucleotide bases function as informational gates. When the pi electrons of a nucleotide base are excited, an exchange of protons is produced between the 2 complementary bases. The result is the displacement of the double conjugated bonds which facilitate the intermolecular transmission of the electronic wave of excitation by an electromagnetic coupling. 2. Each triplet of nucleotide bases of DNA fixes a certain amino acid (as in the genetic code). Between the nucleotide bases and the amino acids there are constituted informational gates, which ensure the circulation of the electronic wave of excitation.

Computers↗
PubMed1975

Learning and evolution.

Between the trinucleotides standing on the 2 chains of DNA, connections are made by means of amino acids, according to the signals received from the environment. Three types of connections are formed: the succession and the simultaneity connections, which explain the process of learning, and the evolutionary connection, which produces the phylogenetic evolution.

Biological Evolution↗
PubMedDate not supplied

French classification for child and adolescent mental disorders.

This report presents the French Classification of Child and Adolescent Mental Disorders (CFTMEA), operational since 1983 and validated through a broad multicentric study. CFTMEA is now the classification of reference for French child psychiatrists, who appear to be comfortable with it because it fits their diagnostic and therapeutic work. It bases its clinical categories on a psychopathological approach which includes an appraisal of potentials and prognosis. CFTMEA is deliberately built on two quite distinct axes: Axis I: basic clinical categories, and Axis II: associated and possibly etiological factors. The CFTMEA favors a broad appraisal of the disorders that it classifies, seeking whenever possible to establish a structural diagnosis based on psychodynamic psychopathology. The CFTMEA does not claim to be atheoretical, but does not impose a theoretical allegiance, because it is compatible with any etiological concepts. The CFTMEA's last revision (R 2000) is in an advanced phase of validation.

Adolescent↗
PubMedDate not supplied

The mechanism by which the energy is released at the level of the flavoenzyme molecule during the transfer of two electrons.

The model of a mechanism producing the excitation of two electrons by the rotation of an orbital is presented functioning at the level of the flavoenzyme molecule. According to this model, during the transfer of two electrons from an NADH coenzyme to a flavoenzyme molecule, in a reaction cavity of the flavoprotein, two (Fe2+:S) covalent bonds are formed. Subsequently to the electric polarization induced by the formation of some intermolecular connections and by some fixed ions, and (Fe2+:S) orbital turns with an angle, having the nucleus of the sulfur atom as a pivot point, in such a way that an (Fe2+) ions is left out from the covalent bond, and it is replaced by a proton (released from a water molecule). A new (S:H) orbital is formed. Within this (S:H) orbital, the proton moves towards the nucleus of the sulfur atom, from 2.10 A degrees internuclear distance (position in which the proton was included by the orbital rotation) to 1.36 A degrees internuclear distance--corresponding to the length of the (S:H) covalent bond. By the proton movement, the two electrons of the (S:H) orbital arrive on an excitation state level. Then, they fall to their fundamental level and deliver two quanta of electronic excitation, which are transmitted further and help the synthesis of an ATP molecule.

Adenosine Triphosphate↗
PubMedDate not supplied

The asymmetry of biological molecules and the symmetry CPT.

Due to the interference of weak nuclear and electromagnetic forces, a specific relationship exists between the electric polarization of the covalent bonds and the spatial orientation of certain atoms and chemical groups in the framework of matter. The symmetric in the mirror corresponding to this relationship is in antimatter (symmetry CP). In this transformation, time preserves its direction of development (symmetry CPT).

Chemical Phenomena↗
PubMedDate not supplied

The non-conservation of parity in the domain of elementary particles and a possible mechanism for the delivery of energy from the ATP molecule.

A model is presented for the delivery of energy from the ATP molecule. The mode indicates the development of the following stages: a) A water molecule is fixed at the level of the high energy bond, b) The electronic cloud of the (PIII----OII) covalent bond turns around the nucleus of the oxygen (OII) atom. Subsequently, the phosphorus atom is left out from the covalent bond and the proton of the water molecule is included in a new covalent bond. c) The proton moves from 1.76 A to 0.97 A internuclear distances. The internuclear energy diminishes and the difference in energy is transmitted to an electron of the covalent bond, which presents a suitable spin and direction of motion to receive it. The symmetry in mirror is not conserved in this process. The symmetrical in the mirror corresponding to this process can exist only in antimatter.

Adenosine Triphosphate↗