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Biomedical subjects

C Pollick

Publications and source records attributed to C Pollick.

45 records · Page 3Linked to original sources
PubMed1982

The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study.

Commercially available disopyramide is a racemic mixture of equal parts of dextrorotatory (d-) and levorotatory (l-) optical isomers. We studied the cardiac effects of i.v. administration of each isomer and the racemic mixture (dl-) in six normal males by digitized echocardiography, systolic time intervals and ECG. Both isomers and the racemic mixture produced equally marked dose-dependent negative inotropic effects (28.1 +/- 11.8% mean maximal reduction in fractional shortening of left ventricular dimension) and diastolic effects (28.6 +/- 24.1% mean maximal reduction in peak left ventricular filling rate). However, only the d-isomer prolonged QTc duration (by 13.6 +/- 5.2% at maximum, p less than 0.001 vs l-isomer). We conclude that disopyramide, in the doses used, produces marked adverse effects on left ventricle systolic and diastolic function in normal subjects independent of optical rotation. The production of these effects by the l-isomer without affecting QTc duration suggests different subcellular mechanisms for the myocardial depressant effects and some of the electrophysiologic effects of disopyramide.

Adult↗
PubMed1978

Echocardiography in a district general hospital.

A referral service for echocardiography was established in a district general hospital. One hundred and three patients were studied and the benefits to defined groups of referrals were evaluated. It is concluded that the introduction of echocardiography into this setting is of advantage to many patients with cardiac disease and should therefore be encouraged.

Adolescent↗
PubMedDate not supplied

Echocardiographic and cardiac Doppler assessment of mice.

Recent studies have suggested that intermediate-frequency M-Mode transthoracic echocardiographic imaging is a promising method for evaluating the left ventricle in transgenic mice. However, there is a paucity of data regarding two-dimensional (2-D) echocardiography and cardiac Doppler echocardiography in this model. Therefore we studied 15 mice (body weights 38 to 65 gm) with an ultrasound system equipped with a 9 MHz transducer. M-mode, 2-D, pulsed, and color-flow Doppler studies were performed. Mean +/- SD for septal, posterior wall, and left ventricular cavity dimensions at end diastole were the following: M-mode: 1.1 +/- 0.2, 1.0 +/- 0.2, and 3.7 +/- 0.7 mm; 2-D: 1.0 +/- 0.2, 1.1 +/- 0.3, and 3.0 +/- 0.6mm. Left ventricular fractional shortening was assessed from the M-mode echocardiogram: mean 53.7% +/- 10.7% (range 42% to 77%). 2-D assessment of left ventricular mass correlated better with left ventricular mass identified at necropsy than left ventricular mass identified by M-mode echocardiography (r = 0.70; p = 0.007 versus r = 0.07; p not significant). 2-D visualization of left ventricle, proximal aorta, and aortic and mitral valves was excellent and was obtained mainly from a "parasternal" window. Apical views were more difficult to obtain. Mean +/- SD for aortic peak and mean velocities and velocity-time integral were 0.53 +/- 0.13, 0.32 +/- 0.08, and 0.025 +/- 0.008 m/sec. Estimated stroke volume was 0.0506 +/- 0.018 ml/beat. Cardiac output was 12.64 +/- 7.87 ml/min. Mean +/- SD for mitral peak E, peak A, and E/A ratio were 0.45 +/- 0.09 m/sec, 0.19 +/- 0.06 m/sec, and 2.4 +/- 0.66 m/sec, respectively. In all mice the E/A ratio was greater than 1 (range 1.76 to 3.6). Color-flowing imaging clearly displayed normal mitral inflow and left ventricular outflow. In one mouse, aortic regurgitation was recorded by pulsed Doppler echocardiography. Echocardiographic, pulsed, and color-flow Doppler assessment of mice is feasible. In this study left ventricular mass was assessed better by 2-D measurement of left ventricular dimensions. Assessment of left ventricular performance is feasible. Color Doppler-guided evaluation of aortic flow and aortic root measurement permits assessment of stroke volume and cardiac output.

Animals↗
PubMedDate not supplied

Isolated thickening of one aortic cusp: preferential thickening of the noncoronary cusp.

Over a 2-year period we identified 197 patients with the previously undescribed finding of isolated thickening of one aortic cusp. The noncoronary cusp was involved most frequently in 56% (p less than 0.01), followed by the right coronary cusp in 35%, and the left coronary cusp in 9%. Isolated thickening of one aortic cusp occurs more commonly in male patients (64%) (p less than 0.01) and at an earlier age (65 years) than mitral annular calcification (70 years) (p less than 0.001).

Age Factors↗
PubMedDate not supplied

Transesophageal echocardiography: experience of a Canadian centre.

Transesophageal echocardiography (TEE) is a new application of echocardiography in which an ultrasonic transducer is positioned in the esophagus and stomach to obtain images of the heart without interference from lung and bone. It is particularly useful in the assessment of left atrial masses, atrial septal defects, mitral valve disease, valvular prostheses and aortic dissection. In the operative setting, TEE is used to detect early myocardial ischemia in patients with coronary artery disease undergoing noncardiac surgery as well as in the assessment of the results of valvular surgery. This review examines the technique of TEE, its indications and the early experience with the first 100 patients examined at the Toronto Western Hospital with this technique.

Canada↗