13 children with frequently relapsing and/or steroid-dependent idiopathic nephrotic syndrome (INS) were treated with levamisole. 2.5 mg of levamisole per kilogram body weight twice a week (cycle A) were administered to all patients during 2-16 months (mean 5.8). A daily administration of the same dose of levamisole was given during 2-9 months (mean 4.9) to 8 patients who did not respond to cycle A (cycle B). A beneficial effect was observed in 6 cases: 4 with cycle A and 2 with cycle B. These patients suffered no relapse despite a significant decrease in the amount of prednisone administered or its discontinuation and they experienced a remission period of 7-29 months without prednisone administration. The side effects of the therapy turned out to be minimal both with cycle A and B. Levamisole may be effective in frequently relapsing and/or steroid-dependent INS with minimal side effects.

Child↗

PubMedDate not supplied

Proteinuria and statural growth.

In order to assess the possible effects of proteinuria on statural growth, we studied 14 children with various glomerulopathies and proteinuria persistently above 30 mg/kg/day which were followed-up for 1.5-4.3 years. They had received only short-term steroid therapy or no steroids at all. During the follow-up, 3 patients lost 1-2.1 height standard deviation scores. These patients had proteinuria above 100 mg/kg/day with associated glycosuria, and they went into chronic renal failure. The other patients had minor variations of the growth curve. In our experience heavy proteinuria represents a risk factor for growth delay when it is associated with glycosuria and chronic renal failure.

Body Height↗

PubMedDate not supplied

[Glomerulonephritis caused by a shunt: description of a case].

The authors report a case of shunt-nephritis due to bacteremia from Stafilococcus albus. Kidney biopsy, comprehensive of IF study allowed to assess the diagnosis of a disease from immunocomplexes. The Authors stress the importance of a close follow-up of patients who carry liquoral shunt for an early recognition of symptoms of glomerulopathy.

Cerebrospinal Fluid Shunts↗

PubMedDate not supplied

[Utilization of sodium acetate by patients with chronic renal failure on chronic hemodialysis].

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Acetates↗

PubMedDate not supplied

[Chronic renal insufficiency of childhood. Analysis of the principal causes and rate of deterioration of renal function in 48 children].

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Adolescent↗

PubMedDate not supplied

[Must renal biopsy be still performed in "lipoid nephrosis"? (author's transl)].

In 52 out of 272 children with one of the following diseases: nephrotic or nephritic syndrome, persistent humaturia and/or proteinuria, renal biopsy was performed on the basis of commonly accepted indications. 18 biopsies were from patients with a clinical picture of lipoid nephrosis and clinical course of "non responders" or "frequent relapsers" types. All of them showed the histologic pattern of minimal changes and had a value of Y index according to ISKCD greater than 0,85. Moreover all patients with minimal changes nephrotic syndrome had a Y index greater than 0.85. If these observations will be confirmed renal biopsy would not later be indicated in children with "lipoid nephrosis".

Biopsy↗