Search PubMed⌕ Search

Biomedical subjects

C Plets

Publications and source records attributed to C Plets.

At least 91 records · Page 5Linked to original sources
PubMed1989

The effects of propofol on intracranial pressure and cerebral perfusion pressure in patients with brain tumors.

In 7 patients with a brain tumor and intracranial hypertension treated by ventriculosubcutaneous drainage, intracranial pressure and cerebral perfusion pressure were continuously monitored during induction of anesthesia with fentanyl 1.5 micrograms/kg, propofol 2.5 mg/kg and vecuronium 0.1 mg/kg. End-tidal pCO2 was kept constant by manual ventilation and arterial pCO2 was verified before induction and before and after intubation. Five minutes after induction the patients were intubated and measurements continued for five more minutes. Mean arterial pressure decreased from 102 (+/- 9.8) mmHg to 57 (+/- 11.6) mmHg (p less than 0.01). Intracranial pressure did not change significantly before intubation. However in two patients intracranial pressure increased before intubation due to a significant rise in arterial pCO2. In 4 of the 7 patients an important increase to 25 (+/- 4.6) mmHg in intracranial pressure was observed during intubation. Cerebral perfusion pressure decreased from 88 (+/- 4.6) to 45 (+/- 9.8) mmHg (p less than 0.01) before intubation, but did not differ from the baseline during and after intubation. It is concluded that propofol 2.5 mg/kg in a bolus injection does not increase ICP but can produce a significant decrease of the cerebral perfusion pressure due to a marked decrease in mean arterial pressure in patients with a brain tumor.

Adult↗
PubMed1988

Interdigestive motility and motilin in hypophysectomized patients.

Basal fluctuations of motilin and their correlation to intestinal motor activity were studied in five hypophysectomized (anterior lobe resection) patients. A cyclic pattern of motor activity identical to the one described in normal volunteers was observed. The mean interval between two activity fronts (AF) was 115 min, which is not significantly different from the normal length. Motilin levels were within the normal range, and fluctuations correlated with the occurrence of an AF. The mean difference between motilin levels 15 min before the AF and at the time of the start of the AF was +15 pM (P less than 0.05). For the levels 15 min after the AF the mean difference was -9 pM (P less than 0.05). These values correlate well with those reported by us in normal volunteers, in whom the mean differences were +11 pM and -14 pM, respectively. It is concluded that the adenohypophysis is not involved in the regulation of motilin levels or in the regulation of interdigestive motility in man.

Digestion↗
PubMed1987

Unusual combination of anomalies of lumbar nerve roots.

Different types of anomalies of the lumbosacral nerve roots are documented in the literature. However, combinations of anomalies in one single person appear to occur very seldom. This report describes a unique combination of adjacent, conjoined and anastomosed lumbosacral nerve roots.

Humans↗
PubMed1986

The value of immediate post-operative routine CT related to uncomplicated ventricle drainage in childhood hydrocephalus.

Retrospectively we assessed the value of routine postoperative CT scans in 113 children shunted for hydrocephalus. Of the 165 routine CT scans 13 showed fortuitous findings (= 8%) with a change in treatment accompanied by questionable benefits in only 2 (= 1.3%). Therefore we suggest that post-operative CT should not be performed as a routine examination but only on clinical grounds.

Adolescent↗
PubMed1985

Tension pneumocephalus in association with ventriculoperitoneal shunt.

The authors report a case of tension pneumocephalus in association with a ventriculoperitoneal shunt for obstructive hydrocephalus, due to the presence of a pineal tumour. In this unique form of tension pneumocephalus, air from the middle ear must have penetrated into the brain parenchyma and later on into the ventricular system through pre-existing congenital defects in the bony tegmen tympani and the covering dura mater. The possible pathogenetic mechanisms of this kind of tension pneumocephalus are discussed.

Adult↗
PubMed1985

Enlarged persistent anterior fontanel following head injury. A case report.

A 2-year-old child is reported with an unusual large anterior fontanel. The boy sustained a head injury at the age of 10 months. Post traumatic skull X-rays showed a parietal bone fracture. At the age of 2 years a leptomeningeal cyst underlying the anterior fontanel was found on CT. A causal relation between the persistent anterior fontanel and the roentgenographic findings is discussed.

Arachnoid↗
PubMed1980

[Cerebellar tumours in the child. Technic and operative results (author's transl)].

The authors present a series of 95 cerebellar tumours in the child. They discuss the relationship between the clinical syndrome and the histological nature on the one hand and the site of the tumour on the other hand. Favourable operative results, characterised by a very low mortality and by the absence of grave postoperative complications, are attributed to as complete an excision as possible of the tumour and preoperative normalisation of intracranial pressure by the installation of ventriculo-subcutaneous drainage.

Adolescent↗
PubMed1979

Catecholamine secreting tumor of the glomus jugulare.

A case of endocrinologically active glomus jugulare is presented. The localization within the tumor of the catecholamine hyperproduction was demonstrated by selective venous sampling from the vena jugularis externa draining the tumor. The norepinephrine/epinephrine ratio was high and of the same order in blood, urine and cerebrospinal fluid. Bioassay showed high levels of intratumoral norepinephrine and epinephrine. The ways of treatment and their influence on the catecholamines are briefly discussed. In every phaeochromocytoma-like syndrome both the existence of catecholamine hyperproduction and the anatomical site of this hypersecretion have to be precisely documented in order to define the correct treatment to be applied.

Catecholamines↗
PubMedDate not supplied

Risk analysis of thrombo-embolic and recurrent bleeding events in the management of intracranial haemorrhage due to oral anticoagulation.

PURPOSES: Intracranial haemorrhage (ICH) is a rare but potentially devastating complication of oral anticoagulants (OAC). This raises the difficult clinical choice between either permanent cessation of OAC, or continuing OAC and if so, when to restart. To make this choice, one needs to balance the thrombo-embolic risk after cessation of OAC against the risk of recurrent intracranial haemorrhage when OAC are restarted. There are few published data to base this difficult clinical decision on. METHODS: We present an observational study of a consecutive series of 108 patients, collected prospectively and admitted to our department, with an OAC-related intracranial haemorrhage, in whom we assessed the thrombotic event rate and the recurrent intracranial bleeding rate during follow-up. RESULTS: In the 25 patients in whom OAC were reinstituted no new thrombo-embolic events occurred (0/506 unprotected patient-days). In the group of patients in whom OAC were not restarted (n = 81), the thrombo-embolic event rate was 8/11590 unprotected patient-days, of which only 2 were cerebrovascular thrombo-embolisms. The overall risk of a thrombo-embolic complication can be estimated to be 0.66 events/1000 patient-days at risk (95% exact confidence limits of 0.3 to 1.3 events/1000 patient-days at risk). In three patients the thrombo-embolic event was fatal. We saw recurrent intracranial bleeding in eight patients, 2 of which were fatal. Seven of these occurred before the restarting of the OAC. CONCLUSIONS: In OAC-related intracranial haemorrhages, OAC can be stopped safely for a considerable period, with a very low overall thrombotic event rate. The recurrent bleeding risk after restarting OAC is low. Recurrent bleeding mostly occurred before restarting OAC and is probably caused by insufficient or unsustained correction of the initial coagulation deficit. Immediate reversal of anticoagulation provides the patient with the best possible treatment options including surgery. OAC-related intracranial haemorrhages can therefore be actively treated.

Administration, Oral↗