Short-term surgical denervation increases 3H-clonidine binding in rat salivary gland.
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Animals↗
Biomedical subjects
C Pimoule
Publications and source records attributed to C Pimoule.
Chronic sympathetic denervation increases muscarinic cholinoceptor binding in the rat submaxillary gland.
Superior cervical ganglionectomy was found to produce a large decrease in the cocaine-sensitive accumulation of 3H-noradrenaline in the rat submaxillary gland, indicating an effective sympathetic denervation. Six weeks after unilateral denervation the muscarinic cholinoceptor binding of 3H-QNB was increased by over 50% compared to the contralateral, innervated gland. There were no differences in the Kd values between the innervated and denervated glands. These results suggest that changes in muscarinic cholinoceptor density might be in part responsible for the postsynaptic supersensitivity to cholinoceptor agonists observed after chronic sympathetic denervation.
Animals↗
GABA metabolism in cultured glial cells.
GABA-transaminase has been characterized in cultured astrocytes. It is identical to the synaptosomal and perikaryal enzyme in terms of charge, molecular weight, and stability, but it differs in its affinity for GABA, which is much higher in the glial compartment. GABA-transaminase has been shown to be inducible by high GABA concentrations, which suggests that astrocytes have the possibility not only to transport GABA but also to metabolize the amino acid which is taken up.
4-Aminobutyrate Transaminase↗