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Biomedical subjects

C Peterson

Publications and source records attributed to C Peterson.

At least 91 records · Page 5Linked to original sources
PubMed1998

The role of private prayer in psychological recovery among midlife and aged patients following cardiac surgery.

Issues related to psychological recovery following coronary bypass surgeries (CABG) have emerged in recent years. Other research has shown the effects of spiritual or religious activities on health and aging. However, little is known about the relationship of spiritual coping, including religious coping, to post-CABG adjustment. This study addressed multifactorial determinants of postoperative psychological recovery and the effects of private prayer, a form of spiritual coping, on the recovery of 151 older patients. Results show that most patients pray about their postoperative problems and that private prayer appears to significantly decrease depression and general distress one year post-CABG.

Adaptation, Psychological↗
PubMed1998

Psychosocial factors limit outcomes after trauma.

BACKGROUND: Psychological morbidity compromises return to work after trauma. We demonstrate this relationship and present methods to identify risks for significant psychological morbidity. METHODS: Thirty-five adults were evaluated prospectively for return to functional employment after injury using demographic data, validated psychological and health measures, and the Michigan Critical Events Perception Scale. Evaluation was conducted at admission and at 1 and 5 months after injury. RESULTS: Poor return to work at 5 months was attributable to physical disability (p < 0.05) and psychological disturbance (p < 0.05) in a regression model that controlled for preinjury employment and psychopathologic factors as well as injury severity. A high score on the Impact of Events Scale administered during acute admission predicted development of acute stress disorder at 1 month (p < 0.01, odds ratio (OR) = 9.4) and posttraumatic stress disorder at 5 months (p < 0.05, OR = 6.7). Peritraumatic dissociation on the Michigan Critical Events Perception Scale was predictive for development of acute stress disorder (p < 0.05, OR = 5.8) at 1 month and posttraumatic stress disorder (p < 0.05, OR = 7.5) at 5 months. CONCLUSION: Psychological morbidity after injury compromises return to work independent of preinjury employment and psychopathologic condition, Injury Severity Score, or ambulation. A high Impact of Events Scale score or peritraumatic dissociation at admission predicts this morbidity.

Activities of Daily Living↗
PubMed1998

Presurgery expectations, postsurgery satisfaction, and psychosocial adjustment after epilepsy surgery.

PURPOSE: The medical benefits of epilepsy surgery are well documented, but the psychosocial consequences of surgery have received less attention. This is especially true of the roles of expectations and satisfaction in postsurgery functioning. The present study was designed to examine the relationships between expectation, satisfaction with surgery, and psychosocial functioning in patients and their significant others before and after epilepsy surgery. METHODS: The neuropsychology findings of 79 patients undergoing epilepsy surgery were examined from assessments made before, 2 months after, and 1 year after anterior temporal lobectomy (ATL) was performed. The Minnesota Multiphasic Personality Inventory (MMPI) and the Washington Psychosocial Seizure Inventory (WPSI) were used to assess psychosocial functioning. A subset of 32 patients and their significant others were followed prospectively with an additional semistructured interview to assess expectations for and satisfaction with surgery outcome. RESULTS: Before surgery, patients showed considerable problems with psychosocial adjustment. After surgery, patients in the seizure-free group showed improvements on the psychosocial measures at both follow-ups, whereas patients with continued seizures showed improvement at the 2-month follow-up and then a decline to baseline or worse at the time of the 1-year follow-up. Subjects who were studied prospectively had high presurgery expectations for seizure elimination. After surgery, subjects whose expectations were met reported high satisfaction whereas subjects whose expectations were not met reported low satisfaction. Satisfaction with surgery was associated with better psychosocial functioning. CONCLUSIONS: Such data help elucidate the ways in which successful epilepsy surgery results in improved psychosocial functioning. The results identify ways to increase the likelihood that both patients who are seizure-free and those with reduced seizure frequency may benefit from surgery.

Adaptation, Psychological↗
PubMed1998

Self-care and psychosocial adjustment of patients following cardiac surgery.

This research examined the role of self-care behavior of 151 patients (aged 40 to 80) on general psychological distress at one year after coronary artery bypass graft (CABG) surgery. A tested hypothesis was that self-care practices would be associated with a lower level of distress one year after surgery. The results supported the beneficial effect of self-care on psychological adjustment, after controlling for the effects of the number of other chronic illnesses and post-CABG depression. The findings suggest that social work in health care and in-home care may help promote the psychosocial recovery process following surgery.

Adaptation, Psychological↗
PubMed1998

Access to primary care for patients with diabetes at an urban public hospital walk-in clinic.

The purpose of this study was to determine the regular source of primary care, the content of care, and barriers to accessing primary care for 218 medically indigent adults with diabetes mellitus. Patients were surveyed at a public hospital walk-in clinic and were queried regarding demographics, regular source of care, and the content of care they received during the preceding year. Seventy percent of the patients were medically uninsured, and 60 percent had household incomes under $10,001. Forty-three percent reported no regular source of care, and 18 percent named an episodic care site as their regular source. Patients with a regular source of primary care had twice as many annual ambulatory visits as those without primary care. Patients with a regular source of primary care reported more diabetic-related services than those without. This patient population is largely poor and uninsured and has difficulty accessing primary care.

Analysis of Variance↗
PubMed1997

A meta-analysis of zinc salts lozenges and the common cold.

BACKGROUND: In the United States, the common cold has been estimated to cost more than $3.5 billion a year. Despite several randomized clinical trials, the effect of treating colds with zinc salts lozenges remains uncertain because of conflicting results. OBJECTIVE: To conduct a meta-analysis of published randomized clinical trials on the use of zinc salts lozenges in colds using a random effects model. RESULTS: Eight clinical trials of treating adults with zinc salts lozenges were identified. After excluding 2 studies that used nasal inoculation of rhinovirus, 6 trials were combined and analyzed. The summary odds ratio for the presence of any cold symptoms at 7 days was 0.50 (95% confidence interval, 0.19-1.29). CONCLUSION: Despite numerous randomized trials, the evidence for effectiveness of zinc salts lozenges in reducing the duration of common colds is still lacking.

Administration, Oral↗
PubMed1997

XPC interacts with both HHR23B and HHR23A in vivo.

XP group C protein (XPC) and a human homologue of RAD23, HHR23B, have previously been shown to copurify in a tightly associated complex. Here, we show that XPC interacts in vivo, by means of the yeast two-hybrid system, with both HHR23B and a second homologue of RAD23, HHR23A. Domain mapping studies have revealed that both RAD23 homologues interact with XPC at the same highly conserved region in the C-terminal half of the protein. XPC mutants deleted within this domain and that are highly deficient in binding both RAD23 homologues are also highly defective in complementing XPC cells in vivo. Domain mapping studies have also identified a region in the N-terminal half of HHR23B that contains the XPC interactive site. This domain is highly conserved among HHR23B, HHR23A, and RAD23.

Amino Acid Sequence↗
PubMed1997

Interviewing children about trauma: problems with "specific" questions.

A methodological ambiguity is described that may well adversely affect the quality of information provided by young child witnesses. Because the information children provide during interviews is sometimes the only evidence in forensic situations, its quality is a serious concern. "Specific" questions are often necessary to elicit enough information, but we describe a confusion between wh- questions (which request particular information) and yes/no questions (which merely require confirmation or disconfirmation). Research in which children are systematically interviewed about stressful medical experiences is reviewed, and we present results of a pilot investigation in which 2- to 13-year-old children were interviewed about traumatic injuries necessitating hospital treatment. Yes/no questions were problematic for preschoolers. Implications for testimony are discussed.

Adolescent↗
PubMed1997

Content analysis of archival data.

Content analysis can be a particularly suitable method for measuring cognitive variables from archived texts. Although content analysis has been underused by clinical psychologists, there are many benefits to this strategy. Longitudinal studies can be conducted retrospectively, the range of possible research participants can be expanded to include individuals otherwise unavailable (e.g., the famous or the dead), existing data sets can be used and reused to answer new questions, and studies across cultures and across levels of analysis (individual vs. group) can be facilitated. To illustrate the use and usefulness of content analysis to measure cognitive variables, the authors focus on the examples of causal attributions and integrative complexity, describing past research and sketching future applications to clinical research and practice.

Awareness↗
PubMed1997

Explanatory style, family expressiveness, and self-esteem among Asian American and European American college students.

Fifty-nine Asian American and 40 European American college students completed questionnaires measuring explanatory style, family expressiveness, and self-esteem. In both groups, a global explanatory style correlated with low self-esteem, but only among European Americans was an internal style associated with low self-esteem. The two groups differed in reported styles of family expressiveness, with Asian Americans indicating more emotional restraint. The participants who reported more negative submissiveness had a more global explanatory style, whereas those who reported more positive dominance had a less global explanatory style. An additional measure developed to assess attribution to collectivities did not distinguish the two groups. Results were discussed in terms of the cross-cultural generality of the learned helplessness reformulation.

Adolescent↗
PubMed1997

Psychological recovery from coronary artery bypass graft surgery: the use of complementary therapies.

This study explored the use of complementary therapies that patients pursued after coronary artery bypass graft (CABG) surgery and its relation to psychological recovery, particularly postoperative distress. Information about post-CABG Surgery depression and general distress, health-care practice thereafter, perceived social support, and chronic conditions other than cardiac disease was gathered from a sample of 151 patients through two questionnaires. Additional cardiac, surgical, and demographic data were obtained from medical records. Structural equation modeling (LISREL 8) was used to test the hypothesis that patients' health-care practices improved psychological adjustment after CABG. Of the sample, 85% practiced complementary approaches, especially prayer, exercise, and lifestyle-diet modification. The number of the other chronic illnesses strongly predicted post-CABG depression and general distress. CABG patients who pursued complementary approaches, particularly exercise and prayer, had better psychological recovery.

Adaptation, Psychological↗
PubMed1997

Insecticidal activity of monoterpenoids to western corn rootworm (Coleoptera: Chrysomelidae), twospotted spider mite (Acari: Tetranychidae), and house fly (Diptera: Muscidae).

Acute toxicities of 34 naturally occurring monoterpenoids were evaluated against 3 important arthropod pest species; the larva of the western corn rootworm, Diabrotica virgifera virgifera LeConte; the adult of the twospotted spider mite. Tetranychus urticae Koch; and the adult house fly. Musca domestica L. Potential larvicidal or acaricidal activities of each monoterpenoid were determined by topical application, leaf-dip method, soil bioassay, and greenhouse pot tests. Phytotoxicity was also tested on a corn plant. Citronellic acid and thymol were the most topically toxic against the house fly, and citronellol and thujone were the most effective on the western corn rootworm. Most of the monoterpenoids were lethal to the twospotted spider mite at high concentrations; carvomenthenol and terpinen-4-ol were especially effective. A wide range of monoterpenoids showed some larvicidal activity against the western corn rootworm in the soil bioassay. Perillaldehyde, the most toxic (LC50 = 3 micrograms/g) in soil, was only 1/3 as toxic as carbofuran, a commercial soil insecticide (LC50 = 1 microgram/g). Selected monoterpenoids also effectively protected corn roots from attack by the western corn rootworm larvae under greenhouse conditions. alpha-Terpineol was the best monoterpenoid in the greenhouse pot test. The acute toxicity of monoterpenoids was low relative to conventional insecticides. Some monoterpenoids were phytotoxic to corn roots and leaves. l-Carvone was the most phytotoxic, whereas pulegone was the safest. The results with thymyl ethyl ether, one of the synthetic derivatives of thymol, showed a potential of derivatization to reduce monoterpenoid phytotoxicity.

Animals↗
PubMed1997

Monitoring of methotrexate and 7-hydroxymethotrexate in saliva from children with acute lymphoblastic leukemia receiving high-dose consolidation treatment: relation to oral mucositis.

The purpose of the study was to find out if saliva concentrations of methotrexate (MTX) and its main metabolite, 7-hydroxymethotrexate (7-OHMTX), can predict oral mucositis in children with acute lymphoblastic leukemia (ALL) after treatment with high-dose consolidation therapy. We have also studied the relationship between the concentrations of MTX and 7-OHMTX in saliva and the unbound concentrations in plasma. Twelve patients (36 infusions) were studied during treatment with high-dose MTX as remission consolidation therapy (5-8 g/m2 by 24 h i.v. infusion followed by leucovorin rescue). Plasma and saliva concentrations of MTX and 7-OHMTX were determined concomitantly by HPLC at 20 h and at various times following infusion. Unbound plasma concentrations of MTX and 7-OHMTX were determined after ultrafiltration. Oral toxicity was graded according to the WHO criteria (grade 0-4). The concentrations of MTX and 7-OHMTX in saliva were not directly related to the development of mucositis. In patients with oral mucositis (WHO grade 1 or greater), the ratio to 7-OHMTX and MTX in saliva at 20 h was significantly lower than in patients without symptoms (p = 0.014, Mann Whitney rank sum test), but not at 42 and 66 h after starting the infusion. The salivary concentration of 7-OHMTX at 20 h ranged from undetectable (less than 1 nmol/l) to 1.6 micromol/l. No significant correlation was found between the unbound and total plasma concentrations of MTX and 7-OHMTX and the drug concentrations in saliva at different points in time. The concentrations of 7-OHMTX in saliva were 11, 23 and 13% of the unbound plasma concentrations at 20, 42 and 66 h, respectively, after starting the infusion. The respective median corresponding values for MTX were 1.6, 16.1 and 61.6%. The results suggest that determinations of saliva concentrations of MTX and 7-OHMTX may predict oral mucositis. This opens up the possibility of early identification of patients at high risk of developing oral mucositis in order to intensify topical or systemic treatment of these patients.

Child↗
PubMed1997

Similarities and differences in assessing nausea on a verbal category scale and a visual analogue scale.

The use of verbal category scales in assessing patient symptoms is evolving, but the extent to which reliability and precision are lost in using them as opposed to a visual analogue scale (VAS) remains uncertain. The present study analyzed the concordance between a four-point verbal category scale and a VAS in assessing nausea intensity in patients undergoing chemotherapy. The analysis of a total of 348 simultaneous ratings by 104 women over four cycles revealed good concordance between the scales. The means of the VAS ratings (range 0-100 mm) corresponding to the four verbal categories divided the scale in four almost equally large parts (no nausea = 0.7, mild = 24.8, moderate = 48.3, severe = 75.1). However, the VAS ranges were wide. On an individual level a one-step change in the verbal category was associated with an average change of 20 mm on the VAS. The choice of scale to use should be based on the need in the particular situation. When measuring intensity of nausea in patients, the VAS is a reasonable choice due to its possibly greater ability to detect changes over time. On the group level, findings on a four-point category scale and a VAS on the average seem similar.

Clinical Nursing Research↗
PubMed1997

Cells and mediators from pharyngeal secretions in infants with acute wheezing episodes.

An acute wheezing episode is the most common feature of severe lower respiratory tract infection during infancy. Respiratory syncytial virus (RSV) is the major causative agent. In order to study inflammation during acute wheezing episodes in infants, we wanted to assess the feasibility and contribution of induction of pharyngeal secretions. We therefore compared inflammatory markers in the pharyngeal secretions of 27 infants suffering from acute wheezing episodes with an RSV infection (RSV+) and 18 infants suffering with acute wheezing episodes without RSV infection (RSV-). Pharyngeal secretions were recovered by physiotherapy using isotonic saline. The safety of the procedure was carefully checked. Pharyngeal secretions were homogenized with dithiothreitol. Total cells and eosinophils were counted and levels of eosinophil cationic protein (ECP) and histamine were measured. Induction of pharyngeal secretion was always well tolerated. Eosinophils were present in five RSV+ and seven RSV- patients. ECP levels were not significantly different between the groups. Histamine levels after protein adjustment were significantly increased in RSV+ patients (p<0.01) in comparison to RSV- patients. In this study, we have shown, that pharyngeal secretion can be safely recovered from infants suffering from acute wheezing episodes, and that it can be analysed for enumeration of inflammatory cells and measurement of inflammatory mediators.

Blood Proteins↗
PubMed1997

How gender affects psychological adjustment one year after coronary artery bypass graft surgery.

This research investigated gender differences in psychological adjustment among patients (112 males, 39 females) one year after coronary artery bypass graft surgery (CABG). Information regarding post-CABG depression, non-cardiac chronic conditions, and socioeconomic variables were obtained from a survey. Additional cardiac, surgical, and demographic data were retrieved from a hospital computer database. Women were more likely than men to experience postoperative depression, attributable to their poor health. Depression one year post-CABG was predicted by non-cardiac chronic illnesses, postoperative fatigue and shortness of breath and socioeconomic status.

Adaptation, Psychological↗