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Biomedical subjects

C Perez

Publications and source records attributed to C Perez.

At least 199 records · Page 11Linked to original sources
PubMed1979

[Partial decalcifying algodystrophy].

Partial decalcifying algodystrophy (PDA) appears in two forms: one, a radial form, affects, following a certain metameric topography, one or two radiuses of the hand or of the foot (two cases reported); the other, a zonal form, is more peculiar: only part of a condyle or of the femoral head, are demineralized for two to three months. The authors report 7 cases of this misleading zonal form, 2 of them after histological verification. The image leads to various diagnostic errors: osteitis or infectious osteo-arthritis, acute inflammation close to the bone, and especially malignant processes. However, zonal PDA has its own characteristics: demineralization, that becomes clear only during the second month, and quickly extends over a rather long sub chondral bone surface. Tomography is very useful: it demonstrates better the severe sub chondral osteoporosis and the retention of the bone sole, which becomes detached from the bone. Scintigraphy shows the massive localized or panregional hyperfixation and sometimes other infraradiological sites (hips, knee or ankle). Zonal osteoporosis remains partial and misleading for only 2 or 3 months, after which it becomes a classical panregional form. The rate of development is that of DA. Painful impotence quickly increases, with cure in 6 months.

Adult↗
PubMed1979

[Nature and antibiotic resistance of bacteria encountered in an intensive care unit. Computerized study based on 422 antibiograms].

A computer analysis of 422 sheets of data from antibiograms performed on 146 patients in a resuscitation unit of multipurpose type, was performed. The study comprises the investigation of the nature of the isolated bacteria and the resistance of the organisms to antibiotics alone or in combinations. The results obtained show on the one hand, that there is a development over time of resistance to antibiotics and a change in the nature of the bacteria, and on the other, that a precise knowledge of the bacteriological data concerning a given department enables the intiation of treatment before having the antibiogram results with an increased chance of efficacy. The importance of such a study is controversial.

Anti-Bacterial Agents↗
PubMed1978

Prognosis after metastases in osteosarcoma.

Data from 106 patients with osteosarcoma who developed metastases during treatment were analyzed for prognostic factors for postmetastic survival time. Patients diagnosed in 1971 or later received more intensive chemotherapy and had significantly longer postmetastatic survival time than those diagnosed in 1970 or earlier (P = 0.002). Patients whose metastasis occurred 13 or more months after diagnosis had signicantly longer postmetastatic survival time than those whose metastasis occurred during the first 12 months after diagnosis (P = 0.005). Life-table regression analysis revealed an interaction between "year of diagnosis" and "months to metastasis" which provided a postmetastatic survival advantage for those having metastasis after diagnosis over metastasis at diagnosis for patients diagnosed in 1971 or later but not for those diagnosed in 1970 or earlier (P = 0.093).

Adolescent↗
PubMed1978

Significance of the 48-hour plasma level in high-dose methotrexate regimens.

Plasma methotrexate (MTX) concentrations at 48 hours were determined for 40 patients with osteosarcoma who received 256 infusions of high-dose methotrexate-citrovorum rescue (HD-MTX-CF) regimen. Five manifestations of toxicity (dermatitis, stomatitis, myelosuppression, liver dysfunction, and kidney dysfunction) were considered in the assessment of the overall toxicity. Logistic regression analysis was applied to study the effect of number of prior infusions, age, and 48-hour MTX plasma level on the risk of moderate or severe overall toxicity. Each factor had a significant effect with P less than 0.08. The predicted incidence of moderate-severe overall toxicity in the high-risk group (48-hour MTX level greater than 1.00 x 10(-6) mol/l., prior infusions greater than 10, age greater than or equal to 15 years) was 33.2% compared to only 2.4% in the "low-risk" group (48-hour MTX level less than or equal to 1.00 x 10(-6) mol/l., prior infusions less than or equal to 10, age less than 15 years). The plasma MTX determination at 48 hours postinfusion was found to be independent of both dose infused and patient's age.

Adolescent↗
PubMed1976

Vertebral hydatid disease. Clinical experience with 27 cases.

The authors present 27 cases of vertebral hydatidosis with clinical and laboratory findings. The most frequent location of the lesion was the lumbar spine. Principal neurological symptoms were paraparesis, sphincter disturbances, paresthesia and paraplegia. The average number of surgical interventions per patient was 2.6; the most common procedure was laminectomy with extirpation of the cyst and surgical toilet. The results of surgical treatment were generally good in the immediate postoperative period, but long-term results were poor.

Adolescent↗
PubMed1975

[The coxopathies of Paget's disease. Radio-clinical and anatomopathological study].

A systematic study was carried out on 105 patients with Paget's disease (60 men and 45 women, average age 62 years) involving the acetabulum and/or the femoral head in the juxta-articular zone. In two-thirds of the patients only the pelvis (in particular the acetabulum) was affected, in a quarter both the pelvis and the femoral head were affected, and in one case in ten only the femoral head. 1. 18 coincidental coxopathies should first be excluded (12 coxarthrosis, 2 coxitis, etx.). The occurrence of 17 percent of coxopathies not caused by Paget's disease is normal in older patients (Vignon and Jacquet; Sebban, Lequesne et al.). 2. In 105 cases, there were only 50 coxopathies really due to Paget's disease, of which almost half remained painless. 3. This proportion did not vary with age. On the other hand, coxopathy was more frequent in patients with bipolar, pelvifemoral Paget's disease and above all in Paget's disease with acetabular protrusio. 4. The radiographic appearance is slightly different from that of coxarthrosis; the reduction in joint space is more often internal or supero-internal (50 percent of cases); osteophytosis is usually moderate (22 percent of cases), or absent (48 percent). The geodes are rarely visible : 6 percent of cases. 5. The acquired bone deformations in patients with Paget's disease are classical. In 105 cases, the authors noted 14 acetabular protrusions, all with coxopathies, and 10 coxa vara, 5 of which had coxapathies. Anatomo-pathological studies did not reveal anything in particular about the bone : superimposition of the Paget's disease lesions and of the lesions usually found in cases of coxopathy due to overload, with a dense pressure cone. With reference to cartilage, the lesions of Paget's coxopathies presented several specific characteristics compared with those of common arthrosis : (1) the presence of particularly numerous cupshaped defects on the remaining cartilage; (2) a very basophilic, intra- and extra-cytoplasmic substance impregnated the chondroplasts of the bottom layer, nine times out of twenty-six, an anomaly not observed in cases of arthrosis; (3) pseudo-angiomatous vascular outgrowths from the bone, flush with the articular surface of the acetabulum are a source of bleeding during surgery.

Adult↗
PubMedDate not supplied

Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival.

PURPOSE: The goal of this study was to determine the incidence of metastatic sites in neuroblastoma and the extent to which metastatic sites correlate with age, tumor biology, and survival. PATIENTS AND METHODS: All 648 patients with stage IV and IVS neuroblastoma registered on Children's Cancer Group protocols 3881 and 3891 were analyzed. Metastatic site data were provided by treating institutions and reviewed in patients with central nervous system (CNS), intracranial, lung, or "other" metastases. RESULTS: The incidence of metastatic sites at diagnosis was 70.5% in bone marrow, 55.7% in bone, 30.9% in lymph nodes, 29.6% in liver, 18.2% in intracranial and orbital sites, 3.3% in lung, and 0.6% in CNS. Event-free survival (EFS) was decreased in patients with bone, bone marrow, CNS, intracranial/ orbital, lung, and pleural metastases, and improved in those with liver and skin metastases. In infants, MYCN amplification and unfavorable Shimada histopathology correlated with increased frequencies of bone and intracranial or orbital metastases. In older patients, MYCN amplification correlated with increased frequencies of intracranial or orbital, liver, and lung metastases. Multivariate analysis revealed that metastatic site is not an independent prognostic factor. CONCLUSIONS: Metastatic pattern in neuroblastoma differs with age and correlates with tumor biological features and EFS. These correlations could reflect changes in host or tumor biological features with age resulting in differences in metastatic capacity or tumor affinity for specific sites.

Adolescent↗