[Quinolilhydrazones of acetylpyridine: preparation and biological activity. VII].
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Antiprotozoal Agents↗
Biomedical subjects
C Pellerano
Publications and source records attributed to C Pellerano.
Anticestode quinolinehydrazones.
One hundred and seven 4-quinolinehydrazones were synthesized and tested in vivo against the tapeworm Hymenolepis nana. Twenty-five derivatives showed significant cestocidal activity; structure-activity correlations were performed using Free-Wilson methodology. Two compounds, 2,6-dimethyl-4-[(3-pyridinylmethylene)hydrazino]quinoline and 2,6-dimethyl-4-[2p][(6-methyl)pyridinylmethylene]hydrazino)quinoline, predicted to be maximally active, effected 100% reduction of H. nana in mice at 200 mg/kg, p.o.
Animals↗
Quinolinehydrazones: structure-activity correlations in a new class of anti-mycoplasmal agents.
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Biological Assay↗