Search PubMed⌕ Search

Biomedical subjects

C Pasquier

Publications and source records attributed to C Pasquier.

133 records · Page 8Linked to original sources
PubMedDate not supplied

Superoxide dismutases in polymorphonuclear leukocytes from patients with ankylosing spondylitis or rheumatoid arthritis.

The activity of cyanide-sensitive and cyanide-insensitive superoxide dismutase (CNs- and CNi-SOD) was measured in polymorphonuclear neutrophils isolated from the blood of patients with ankylosing spondylitis (A.S.) or adults with rheumatoid arthritis (R.A.). Our purpose was to detect alterations in the protecting activity of these enzymes that might cause rheumatic lesions secondary to superoxide anion generation in the inflammatory loci. There was no difference in total SOD activity (CNs + CNi) in either A.S. or R.A. when compared to the control group. In contrast, CNi-SOD activity decreased in R.A. and A.S. and CNs-SOD activity rose significantly in A.S. only. None of the changes observed in SOD activity correlated with patient's age, erythrocyte sedimentation rate, clinical evolution of the disease or the drug doses administered. It is concluded that the reduced activity of CNi-SOD might be partly responsible for the reduced protection of the joints against oxygen-free radicals in patients with A.S. or R.A. Other factors however appear to have greater effects on the clinical evolution of these diseases.

Arthritis, Rheumatoid↗
PubMedDate not supplied

[Rolandic paroxysmal epilepsy. Prognostic, electric, clinical limits. Study of 28 cases (author's transl)].

Rolandic paroxysmal epilepsy remains a frequent eventuality in children and even more so than the "minor epilepsy". In more cases, it is easily diagnosed and enables the physician to reassure the family which is usually frightened by the word "epilepsy". Both complementary examinations and therapeutic excesses can also be reduced. In a number of cases, the diagnosis may be questionable. It seems that the features of certain crises, the post-critical deficit, the massive anomalies in post-critical electroencephalogram, the reactivation of the crises during puberty are as many factors liable to moderate a too securising optimism both for the physician and the patient.

Child↗